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E I Vinogradova

Publications and source records attributed to E I Vinogradova.

16 recordsLinked to original sources
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[Cortisol 6beta-hydroxylation pathway in the early neonatal period].

The method of thin-layer chromatography was applied to the study of renal excretion of 6beta-hydroxycortisol in 56 healthy neonates whose mothers were sufferin from late toxemia and in 9 women with 39-40 weeks of gestation. The proportional of 6beta-hydroxycortisol in the sum total of cortisol metabolites excreted in neonates the first week after birth was found to constitute 23.5-26.9%. However, as in adults the predominant route of cortisol metabolism was formation of tetrahydroderivatives whose proportion in the sum total of the excreted compounds constituted 47.7-55.0%. A high 6beta-hydroxycortisol excretion level was noted at the end of pregnancy. Equal amounts of 6beta-hydroxycortisol were excreted in healthy neonates and in children whose mothers were suffering from late toxemia of pregnancy. 6beta-hydroxycortisol formation is the usual independent route of cortisol metabolism in neonates the first week after birth.

Female↗