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Biomedical subjects

E Ilgit

Publications and source records attributed to E Ilgit.

13 recordsLinked to original sources

An unusual indication for surgical treatment of iliac artery aneurysm treated with stented graft previously.

A 70-year-old man was seen with an iliac artery aneurysm and this was treated by an intraluminal graft-stent device introduced through the femoral artery. After the procedure, patency of the artery was proved to be good with control angiography but the mass effect of the aneurysmal sac on the gastrointestinal system did not disappear and we replaced the aneurysmatic segment with a collagen coated graft. The patient then recovered without any complications and gastrointestinal symptoms.

Aged↗

Does thromboxane A2 synthase inhibitor UK-38485 prevent the vasoconstrictor effects of endothelin-1 on rabbit basilar artery?

Prevention of the production of thromboxane A2--a potent vasoconstrictor and aggregating metabolite of arachidonic acid--or infusion of the stable analogues of prostacyclin--which is another cyclo-oxygenase metabolite of arachidonic acid--has been shown to be beneficial in cerebral vasoconstriction. Endothelin-1, a peptide derived from endothelial cells, has been shown to induce a long-lasting cerebral vasoconstriction both in vivo and in vitro. The purpose of this study was to investigate the role of a novel thromboxane A2-synthase inhibitor UK 38485 on the acute vascular and morphological effects of Endothelin-1 applied intra-arterially on rabbit basilar arteries. The inguinal region of twenty four anaesthetized albino rabbits of both sexes were dissected and a catheter was inserted into the aorta via the femoral artery, for control angiography of the basilar artery and intra-arterial injection of ET-1 (0.25 ng total dose) and UK 38485 at a dose of 0.05 microgram kg-1 min-1 for 20 min or saline. Angiographic vasoconstriction quantification and morphological investigations of both vessels and brain stem either by light microscopy or transmission electron microscopy were the techniques applied for the study. We found out that, although the systemic administration of UK 38485 resulted in a potent antagonism of the acute vasoconstriction as visualized in angiographic studies, it did not affect the morphological changes induced by Endothelin-1 on the vessel wall. The results indicated that there might have been an interaction between Endothelin-1 and the prostaglandin synthesis mechanism in acute cerebral vasoconstriction.

Animals↗

Renal artery reconstruction in transplant kidney. Case report.

A 30 years old female patient, to whom a cadaveric kidney transplantation was performed 7 years earlier, presented severe hypertension attacks for 2 years. Renal artery stenosis diagnosed by angiography, PTA could not be performed. She underwent an operation for surgical correction of stenosis and successful internal iliac renal artery anastomosis performed by saphenous vein interposition. The patient was discharged at the fourteenth postoperative day with excellent kidney function and stable blood pressure.

Adult↗

A new experimental flap model in the rabbit: scapular osteomyocutaneous flap.

Despite the use of various types of osteomyocutaneous flaps in clinical practice, there are many unanswered questions regarding their basic physiology. Simple and reliable flap models are needed to investigate these problems. However, very few of these flap models have been described in small animals to date. The purpose of this study was to develop a new osteomyocutaneous flap model in the rabbit. Twenty adult New Zealand white rabbits, weighing 2.5 to 3.0 kg, were used in the reported experiment. In seven rabbits, the anatomy of the axillary vessels was studied by anatomic dissection and selective angiography. Based on this anatomic study, a new osteomyocutaneous flap, namely, the scapular osteomyocutaneous flap, is described in the rabbit model. The flap is composed of a skin island (16 x 8 cm) in the scapular region, the latissimus dorsi and intrinsic shoulder muscles, and the whole scapula as the bony component The flap is based on the axillary vessels, while the skin island and the latissimus dorsi muscle are independently supplied by branches of the thoracodorsal vessels. The flap could thus also be considered as a combined flap model. As an island flap, the flap was replaced in situ in eight rabbits, and transferred to the anterior chest in two rabbits. In the remaining three animals, the flap was transferred to the groin as a free flap. The viability of each component of the flap was demonstrated by direct observation, microangiography, bone scintigraphy, India ink injection study, and histologic examination. The authors concluded that the flap is a simple and reliable osteomyocutaneous flap model, since its dissection is easy; there is a long vascular pedicle with large vessel diameters; and large amounts of skin, muscle, and bone are included.

Animals↗

Primitive persistent carotid-basilar and carotid-vertebral anastomoses: a report of seven cases and a review of the literature.

The persistence of embryonic carotid-basilar and carotid-vertebral anastomoses was investigated retrospectively in 4,400 cerebral angiograms. Six primitive persistent carotid-basilar anastomoses and one primitive persistent carotid-vertebral anastomosis were found. In 4,400 cerebral angiograms, the incidence of primitive carotid-basilar and carotid-vertebral anastomoses was 0.14% and 0.023% respectively. Primitive persistent anastomoses are associated with intracranial vascular anomalies, especially aneurysms. The clinical and pathological findings in combination with these primitive persistent anastomoses were also examined.

Adult↗

Alteration by Iloprost of the vasospastic effects of endothelin-1 in rabbit cerebral vessels.

The reversal of endothelin-1 induced cerebral vasospasm with Iloprost was studied in the rabbit. Vasospasm in the basilar artery was evaluated by angiography; cerebral ischaemia by 'red-neurone-count' on light microscopy and morphological changes by electron microscopy. A potent antagonistic effect of Iloprost against ET-1 was observed in each of the parameters measured.

Animals↗

Computer assisted quantification of vasospasm on angiograms.

We describe a new computer-based, automated method for the assessment of in vivo cerebral vasospasm. Arterial diameter measurements were performed on post-processed digital substraction angiographic images, using "pixel" as the unit. Vasospasm which was difficult to detect by visual inspection could be measured by the "stenosis quantification" program. A computer-assisted method such as we describe might decrease the risk of subjective errors.

Angiography, Digital Subtraction↗

Tuberculoma in the suprasellar cistern: possible CT--misinterpretation as aneurysm.

A patient with multiple intracranial tuberculomas mimicking aneurysms is reported. The diagnosis was established by CT during the treatment of tuberculous meningitis. Anti-tuberculous therapy was continued until the radiological resolution of the lesions. A discussion of previous reports on the non-operative treatment of intracranial tuberculomas is included.

Brain↗

Thromboangiitis obliterans (Buerger's disease) in women (a reevaluation).

Thromboangiitis obliterans (TAO) is an occlusive vascular disease traditionally known to be almost exclusive to young male smokers. The disease was considered to be extremely rare in women, seen only as isolated, novel case reports in the literature. In the past decade, however, a dramatic increase in the incidence of female TAO has been observed. In this paper the authors report 7 cases of clinically and angiographically verified female TAO. The world literature in regard to the diagnostic criteria, changing incidence, and etiology is reviewed. They conclude that the increased use of tobacco among young women in the past two to three decades is responsible for this dramatic change.

Adult↗

Acute appendicitis associated with pneumoperitoneum.

Spontaneous pneumoperitoneum is infrequently encountered as a radiographic finding in association with a perforated appendicitis. This may lead to diagnostic errors, of which every radiologist and surgeon should be aware. We report a case of perforated appendicitis associated with free intraperitoneal gas.

Acute Disease↗

Long-term effects of combined iliac dilatation and distal arterial surgery.

PURPOSE: When standard aortofemoral surgical procedure is combined with lower extremity vascular surgery, problems related with the hospital stay, morbidity, mortality and the cost of treatment will exist. The number of reports relating to combined iliac artery PTA and distal bypass surgery is limited. After the development of stenting procedures, the results of arterial system plasty have much more improved. This report reviews our preliminary experience with iliac artery angioplasty with distal bypass procedures. PATIENTS AND METHODS: A total of 41 patients have undergone combined iliac artery dilatation and distal arterial revascularization. Angioplastic procedures were performed in the angiography suite and distal surgery was carried out at the same day or the day after. Of all patients, 29 underwent percutaneous transluminal angioplasty (PTA) and 12 underwent combined PTA and stent placement. Ipsilateral femoropopliteal bypass was performed as a distal revascularization procedure in all patients. RESULTS: Mean systolic iliac artery pressure gradients improved from 34.7+/-8.6 mmHg to 3.9+/-3.2 mmHg after angioplastic procedures (P < 0.0001). Six patients needed reangioplasty because of restenosis in the follow-up period. Thrombectomy was performed on 1 patient in the early postoperative period and re-do femoropopliteal bypass was performed on two patients in the 2nd and 23rd months. Three minor wound infections were successfully treated with antibiotics and local care. Mean follow-up was 21.4 months (range 1-48 months). By life-table analyses, the overall 4-year cumulative primary patency of combined procedures was 78.1%. CONCLUSION: The results show that the combined procedure is a suitable method for the treatment of patients with multiple stenotic lesions at the iliac and distal arterial levels. We believe that the combined use of PTA and distal vascular surgery by an experienced surgical team will give beneficial results and a highly satisfactory outcome in this group of patients.

Angioplasty↗