Biomedical subjects

E Ishoo

Publications and source records attributed to E Ishoo.

3 recordsLinked to original sources

PubMed2001

Open Zenker's diverticulectomy using stapling techniques.

This is a prospective review of patients who underwent Zenker's diverticulectomy, closure of the pharyngotomy with nonabsorbable staples, and cricopharyngeal myotomy through an open neck approach over a period of 2 years. The study group consisted of 9 men with a mean age of 67 years. The diagnosis of Zenker's diverticulum was based on a barium swallow esophagram. The mean operative time was 1.5 hours, with a mean estimated blood loss of 25 mL. Barium swallow esophagrams performed on the first postoperative day showed no pharyngeal fistulas. Oral feeding was started after the esophagram. One patient was discharged on postoperative day 1, 1 was discharged on postoperative day 3, and the remaining 7 were discharged on postoperative day 2. All patients were able to take oral feeding by postoperative day 1. There were no operative complications in this series. We conclude that stapling with nonabsorbable staples is a relatively safe and effective method for closing pharyngeal defects after Zenker's diverticulectomy. The technique leads to shortening of the operative time and hospital stay, and allows early resumption of oral feeding.

Aged↗

PubMed1999

Predicting airway risk in angioedema: staging system based on presentation.

Angioedema is an immunologically mediated, anatomically limited, nonpitting edema that can lead to life-threatening airway obstruction. To predict the risk of airway compromise in angioedema, we retrospectively reviewed 93 episodes in 80 patients from 1985 to 1995. Intubation or tracheotomy was necessary in 9 (9.7%) cases. Angiotensin-converting enzyme inhibitor use in 36 cases (39%) was associated with intensive care unit (ICU) admission (P = 0.05). ICU stay correlated significantly with presentation with voice change, hoarseness, dyspnea, and rash (P < 0.05). Voice change, hoarseness, dyspnea, and stridor were present in patients requiring airway intervention (P < 0.05). On the basis of our data, we propose a staging system by which airway risk may be predicted from the anatomic site of presentation. Patients with facial rash, facial edema, lip edema (stage I), and soft palate edema (stage II) were treated as outpatients and on the hospital ward. Patients with lingual edema (stage III) usually required ICU admission. All patients with laryngeal edema (stage IV) were admitted to the ICU. Airway intervention was necessary in 7% of stage III patients and in 24% of stage IV cases. No deaths were caused by angioedema. Airway risk in angioedema may be predicted by anatomic site of presentation, allowing appropriate triage with preparation for airway intervention in selected cases.

Adolescent↗

PubMed1995

Divergent mechanisms of insulin-like growth factor I and II on rat hepatocyte proliferation.

Insulin-like growth factors I and II are peptides with a structural homology for proinsulin, and are involved in hepatocyte proliferation. IGF-I and IGF-II, however, have different metabolic roles, and their mechanisms of action are incompletely known. We hypothesized that IGF-I and IGF-II act by different signal transduction pathways. To test this hypothesis, hepatocytes from 200 g male Sprague-Dawley rats were isolated by a two-step collagenase perfusion technique and plated at a density of 10(5) cells/16 mm Primaria plate. Proliferation was measured by [3H]thymidine ([3H]thy) incorporation into DNA, and an autoradiographic nuclear labeling index (LI). To analyze signal transduction, cyclic AMP (cAMP) levels were measured 5 min after addition of reagents by a radioimmunoassay. Reagents (doses) used were: IGF-I (2 nM), IGF-II (2 nM), the inhibitory peptide somatostatin-14 (SS14) (10 nM), and the adenylyl cyclase antagonist dideoxyadenosine (DDA) (10 microM). A summary of the findings is as follows: (1) IGF-I stimulates [3H]thy, LI and cAMP accumulation. (2) IGF-II stimulates [3H]thy and LI but not cAMP; (3) IGF-I but not IGF-II effects are inhibited by SS14 and DDA. We conclude that the hepatotrophic effects of IGF-I and IGF-II occur by different mechanisms: IGF-I is cAMP-dependent, IGF-II is cAMP-independent.

Animals↗