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E Iu Gusev

Publications and source records attributed to E Iu Gusev.

12 recordsLinked to original sources
PubMed1993

[Characteristics of T-suppressors responsible for the competition between cellular and humoral immune response in the spleen].

After intraperitoneal immunization by different sheep erythrocytes doses (1 x 10(6) - 1 x 10(8)) in the spleen of CBA strain and (CBA x C57Bl/6)F1 hybrid mice short-living suppressor cells, which are able to inhibit mature IgM-but not IgG-plaque-forming cells have been revealed. The suppression degree is in direct dependency on the delayed type hypersensitivity effectors activity. The revealed suppressor splenocytes are Thy-1-positive, do not adhere to plastic, are antigen-specific, require the H-2 complex restriction, are unable to homing into regional lymph nodes, their induction is abolished by administration of 200 mg/kg, but not 20 mg/kg of cyclophosphamide. It has been shown that T-suppressors of delayed type hypersensitivity are able to carry out the function of contrasuppressors.

Animals↗
PubMed1993

[Genetic and phenotypic aspects of the interrelationship between cellular and humoral immune response to sheep erythrocytes in mice].

The presence of the two types of immune reactivity has been shown earlier: 1st--with prevalence of delayed type hypersensitivity reaction over antibody response (in mice of C57Bl/6 strain), 2nd--with prevalence of antibody responses (in mice of CBA strain). These differences first of all have been displayed in case of using by suboptimal doses of antigen. In the present study the character of local and common immune response in mice of BALB/c, DBA/2, CC57BR, C3H strains and (CBA x C57Bl/6)F1 hybrid on different sheep erythrocyte doses has been investigated. It has been revealed, that DBA/2, BALB/c and CC57BR mice react according to the first type and mice of C3H strain--according to the second. It has been concluded, that the relationship between cellular and humoral immune response depends on the structure of H-2 complex and in F1 hybrid mice any of parents' haplotypes can predominate, depending on phenotypical factors.

Animals↗
PubMed1991

[Interrelations of cellular and humoral immune response and different doses of sheep erythrocytes in mice].

In experiments on CBA and C57BL/6 mice the generation of antibody-forming cells respectively either in the popliteal lymph nodes or spleen as well as a rate of delayed type hypersensitivity response (DTHR) on the background of subcutaneous (into foot) or intraperitoneal injection of different doses of sheep erythrocytes (from 10(4) to 10(8)) have been studied. In so doing two types of immune response can be isolated on the dependence upon the sensitivity threshold to antigen of DTHR and humoral immunity. Thus in C57BL/6 mice the antigen threshold for DTHR is of one time (in intraperitoneal immunization) or of a two times (in subcutaneous) lower order than for antibody response. In CBA line mice under subcutaneous immunization there can be seen quite an opposite picture while intraperitoneal immunization causes exact correlation of antigen threshold for cellular and humoral immune response.

Animals↗
PubMed1989

[Acute peptic lesions of the gastroduodenal mucosa in patients with obstructive jaundice].

Complex study of the gastric acid-producing activity, the condition of the gastroduodenal mucosa, and the serum gastrin concentration in 80 patients with obstructive jaundice showed that the appearance of acute erosive-ulcerative injuries of the mucosa of the gastroduodenal zone depended on the increase of activity of the peptic factor of the gastric medium. Peptic complications occurred in 27.1% of patients with initial normo and hyperacidity and a high level of blood gastrin. The absence of bile in the duodenum (obstructive jaundice, by-pass biliodigestive anastomoses) stimulated the peptic factor. This is evidently linked with secretin deficiency (absence of the effect of bile on the secretin producing S-cells) leading to weakened inhibiting effect of secretin on the serum gastrin content, which results in hypergastrinemia and hyperacidity.

Acute Disease↗
PubMedDate not supplied

[Effect of glucagon and short-term fasting on the interrelationship of cellular and humoral immune responses].

The effect of subcutaneous administration of 25 micrograms/kg of glucagon and 2-day fasting (as a natural model of hyperglucagonemia) on the accumulation of antibody-forming splenocytes and the expression of a delayed-type hypersensitivity reaction (DTHR) in response to intraperitoneal immunization with sheep erythrocytes at various doses were studied in experiments on random-bred albino mice. A suppressing effect of the hormone on antibody genesis at optimum doses and its stimulating effect at suboptimum doses were revealed. The latter effect took place against a background of DTHR suppression. Glucagon action manifested itself mainly in the effector phase of an immune response and correlated with the effect of two-day fasting on the immune system. A conclusion has been made of a possible competition (at certain doses of antigen) between a cellular and humoral response, whose type can vary during endocrine dysfunction.

Animals↗
PubMedDate not supplied

[Effect of glucagon on the development of delayed hypersensitivity to alloantigens in mice].

A study was made of the effect of different doses of glucagon (0.02, 0.1, 0.5, 2.5 micrograms) on the expression of delayed type hypersensitivity (DTH) in CBA mice. DTH was induced by local administration of allogenic cells, namely mouse splenocytes F1 (CBA X C57BL/6). The suppressive effect of 0.5 and 2.5 micrograms of glucagon and 0.1 micrograms of this hormone when combined with antigen (in the same syringe) on DTH development was revealed. Glucagon action was manifested in the inductive and effector phases of the DTH reaction. Special tests have shown that the glucagon immunosuppressive effect was unassociated with hyperglycemia and mediated by the activation of antigen specific DTH T-suppressors.

Animals↗
PubMedDate not supplied

[Immunomodulating effects of glucagon].

Experiments have shown marked immunosuppressive activity of glucagon during its injection at a dose of 0.4 micrograms for 5 days. The suppression of a primary immune response is mediated by the activation of antigen-specific T-suppressors and is not associated with an increase in insulin secretion and a glycemia value.

Animals↗
PubMedDate not supplied

[Staphylococcus aureus-induced antigen-specific immunosuppression].

In experiments made on noninbred white mice the manifestations of delayed hypersensitivity and the number of antibody-producing cells in regional lymph nodes or the spleen were determined on day 5 after the subcutaneous or intraperitoneal immunization of the animals with sheep red blood cells (SRBC). At the same time the injection of S. aureus antigens simultaneously with SRBC raises the threshold of antigenic sensitivity and decreases the manifestations of cell-mediated and humoral immune response to SRBC. This suppressive effect was even more pronounced in the local immune process and was partially mediated by the hyperproduction of prostaglandins.

Animals↗