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Biomedical subjects

E Iunuskhodzhaev

Publications and source records attributed to E Iunuskhodzhaev.

13 recordsLinked to original sources
PubMed1988

[A method for creating an experimental model of abscess].

A technique of 7-day formation of an intramuscular abscess which is clinically and morphologically similar to that frequently encountered in clinical practice has been tried on 39 rabbits. The standard model proposed involves the following stages: trauma of the spinal erector 2.5-3 cm to the right or to the left from the midline between the second and fourth lumbar vertebra which is produced by a lumbar puncture under either anesthesia with a pulp extractor brought into the muscle up to 1.5 cm and rotating at an angle of 45 degrees; 24 h after the puncture the skin at its site is to be dissected involving subcutaneous fat, superficial and lumbar fasciae, the incision being 1.4-1.6 cm long and parallel to the body axis. The operation is terminated with an introduction of ribbon gauze (10-12 mm in diameter) previously saturated with 24 h suspension culture of staphylococcus (10 ml, concentration of the microorganisms 1.5.10(6] into a pocket made by the clamp tip in the muscle's depth (1.3-1.6 cm) with the help of the handles which produced the opening of 1.2 cm wide. The endpoint is the wound tight layer-by-layer suture.

Abscess↗
PubMedDate not supplied

[A method for assessing the patient's clinical status and for predicting the clinical course of suppurative-inflammatory processes using chemiluminescence].

A new method for the assessment of the severity of the patients' status and prediction of the clinical course of suppurative-inflammatory processes is described, making use of the peripheral blood luminol-dependent chemiluminescence. Early assessment of the patient's condition and prediction of the disease course helps correctly choose the treatment strategy. The technique is simple and rapid, recommending its wide clinical application.

Face↗
PubMedDate not supplied

[The physiological adaptation functions of cellular and humoral immunity in patients with phlegmons of the maxillofacial area].

In order to evaluate the necessity in immunocorrective therapy the patients with maxillofacial phlegmons were tested for their cellular and humoral immunity. A slight increase or decrease in immunity indices before surgery in several patients were not beyond the physiological norm. Postoperative repetitive investigations the immune parameters attained the mean levels or even went higher without immune-correcting therapy. The above changes are characteristic of the peculiarities of cellular and humoral immunity in individual patients and do not require any interference into the immune system.

Adaptation, Physiological↗
PubMedDate not supplied

[Fluorometric method of determining prolylendopeptidase activity in human erythrocytes in normal and pathologic conditions].

A highly sensitive fluorometric method for determination of prolylendopeptidase (PE) activity in human erythrocyte hemolysates in the presence of hemoglobin has been developed. The method is based on measurement of fluorescence of 4-methyl-7-aminocoumarine released in the course of enzymatic reaction from the substrate Z-glycyl-proline-4-methylcoumarine-7-amide. A correlation was introduced for the quenching of fluorescence by hemoglobin. The method is suitable for the determination of PE activity in human erythrocyte hemolysates in various pathological states. The dependence of PE activity on the incubation time, protein and substrate concentrations were studied using the 1,200-fold purified preparations of prolylendopeptidase II. The values of PE activity in erythrocyte hemolysates of healthy donors and in those of patients with odontogenic phlegmons of maxillary-facial area were virtually identical. PE activity in erythrocyte hemolysates of stored blood was 5 times lower than that in the cell hydrolysates of fresh blood. The PE activity was not observed in blood serum of fresh and stored blood of healthy persons and of patients with acute inflammatory processes of maxillary-facial area, as well as in blood serum of patients with hepatitis and glomerulopephritis.

Acute Disease↗
PubMedDate not supplied

[The assessment of the functional activity of peripheral blood neutrophils in patients with odontogenic phlegmons].

To objectively assess the status of patients with odontogenic phlegmons their peripheral blood neutrophils were investigated. Functional activity of these cells was studied in 151 patients with odontogenic phlegmons and the data compared to those in 145 normal subjects. Assessment of leukocyte phagocytic activity by routine methods widely used in clinical practice did not show correlations of this parameter with the severity of the disease clinical course. These studies just showed the general changes in neutrophilic functional activity associated with an inflammation. Thorough studies of neutrophilic functional activity helped the authors develop a new method for assessment of leukocytic phagocytic activity. The results of the new method permitted a sufficiently objective evaluation of the disease severity which is necessary for a correct choice of the treatment policy and method.

Cellulitis↗
PubMedDate not supplied

[The prevention and treatment of patients with suppurative-inflammatory diseases of the maxillofacial area by using vibromassage at autoresonance frequencies].

Autoresonance frequency vibromassage sessions were administered to patients with pyoinflammatory processes in maxillofacial soft tissues. Comprehensive examinations of these patients were carried out to assess the efficacy of this treatment modality; the examinations included rheographic and ultrasonic examinations of blood flow intensity, analysis of neutrophilic activity by chemiluminescence amplitude, measurements of trypsin inhibitor levels and cholinesterase activity, assessment of wound exudate pH values and of resorption capacity of purulent wound tissues. Microbiologic, histologic, cytologic, clinical and biochemical studies were carried out. The findings permit a conclusion that autoresonance vibromassage enhanced biologic purification of the wound from pyonecrotic mass and accelerated reparative regeneration.

Adolescent↗
PubMedDate not supplied

[The diagnostic and prognostic significance of the degree of neutrophilic leukocyte activation in the peripheral blood of patients with odontogenic phlegmons].

Structural and morphologic changes in peripheral blood neutrophilic leukocytes were examined with the aim to diagnose and predict the clinical course of acute pyoinflammatory maxillofacial diseases. Classification of structural and morphologic signs of neutrophilic leukocyte activation levels during odontogenic pyoinflammatory diseases were studied using optic and electron microscopy. There degrees of neutrophilic leukocyte activation were distinguished: inactive, moderately active, and hyperactive. Inactive cells occurred in normal subjects and patients with mild forms of the disease, moderately active ones in patients with mild and medium-severe condition, hyperactive ones in those with medium-severe and grave disease. Increased count of hyperactive neutrophilic leukocytes in the peripheral blood was a sign predicting a grave clinical course of the disease with complications.

Cellulitis↗