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E J Butterworth

Publications and source records attributed to E J Butterworth.

4 recordsLinked to original sources

A TiO(2) dielectric filled toroidal radio frequency cavity resonator for high-field NMR.

R(F) performance in high-field MRI applications is improved by filling the resonator with material of relative dielectric constant approximating that of human soft tissue. We demonstrate this by filling a toroidal cavity resonator operating in TEM(00) (cyclotron) mode with titanium dioxide (TiO(2)) in powdered rutile form, and acquiring phantom, human lower leg and human breast images of good quality at 4.1 T. Images made with this resonator had unusually high SNR, while the level of R(f) power required to produce a 90 degrees flip angle pulse was about a quartes as high for the filled resonator as for the same resonator before filling. Phantom images obtained with the filled resonator had an SNR of nearly 300 at a resolution of 256 x 256 voxels, nearly three times that of images of the same phantom obtained using a standard volume R(f) coil in frequent use at this laboratory. Breast images made at 256 x 256 voxels resolution had an SNR of 174, also unusually high for a volume coil. High-resolution (512 x 512 voxels) were also obtained, with SNR = 60. Preliminary phantom and in vivo human images are presented in this article. Acquiring the phantom and leg images required significantly less R(f) power than did comparable imaging using a conventional coil. In addition, the field lines were focused as they penetrated into the sample, and this resulted in a more homogeneous B(1)-field. We believe that these improvements occurred because the dielectric presence minimizes the large dielectric mismatch between air and sample.

Breast↗

The 31P-NMR stress test: an approach for detecting myocardial ischemia.

31P-NMR spectroscopy has the potential to assess myocardial damage directly and noninvasively by ascertaining the relative abundances of phosphorus-containing compounds relevant to metabolism under stress conditions. Decrease in the PCr/ATP ratio during exercise is an indicator of the level of stress to which the myocardium is subject. This ratio will remain constant under mild to moderate exercise conditions in a healthy subject, but may show a precipitous decrease even under mild exercise when regions of the myocardium are ischemic. The studies examined here indicate that cardiac patients with some forms of ischemia showed a PCr/ATP ratio decrease even under light exercise, while no decrease was observed in patients whose heart disease was known to be nonischemic. Hypertension and nonstenotic chest pain in women can, in some cases, produce a decrease in PCr/ATP ratio. Only the hypertensive patients showed a significant difference in the prestress PCr/ATP ratio when compared with controls. These studies suggest that 31P-NMR spectroscopy before and during mild exercise in the bore of the magnet can be a useful indicator of the presence or absence of an ischemic component to myocardial disorder.

Adenosine Triphosphate↗

Diffusion mapping applied to mesial temporal lobe epilepsy: preliminary observations.

OBJECTIVE: To evaluate whether diffusion mapping could lateralize intractable seizures in mesial temporal lobe epilepsy (MTLE) patients. BACKGROUND: Animal seizure models show acute postictal depression of the apparent diffusion coefficient of water (ADCw), interictal normalization, then chronic elevation. METHODS: The hippocampal plane was imaged with five diffusion weightings along each axis. Three orthogonal ADCw maps were averaged to produce an isotropic ADCw map. RESULTS: In all eight MTLE patients, ADCw was elevated by a mean of 10+/-3% (p<0.01, paired t-test) interictally in the ipsilateral hippocampus, where side of seizure focus was determined electrographically with corroboration by volumetric MRI studies. Measured ADCw values in phantoms and five normal brains agree with published values. CONCLUSIONS: Brain tissue with interictally increased ADCw may represent an epileptogenic region with neuronal loss, gliosis, and expanded extracellular space (hippocampal sclerosis). Thus, diffusion mapping may confirm seizure lateralization.

Adult↗

Magnesium and pH imaging of the human brain at 3.0 Tesla.

Multislice, two-dimensional phosphorus 31 spectroscopic imaging (SI) of human brain was performed in 15 normal volunteers on a 3-Tesla magnetic resonance system. Images of free magnesium concentrations and pH as well as phosphoesters, inorganic phosphate, phosphocreatine, and adenosine triphosphate (ATP), were calculated from the SI data. By using the equations of Golding and Golding (Magn. Reson. Med. 1995;33: 467-474), average [Mg2+] for all brain regions studied was 0.42+/-0.05 mM, whereas average brain pH was found to be 7.07+/-0.03, with no significant regional variations. Phosphorus metabolite concentrations (relative to ATP, assumed to be 3.0 mM/kg wet weight)were 5.39+/-1.88, 1.30+/-0.39, 5.97+/-3.17, and 4.33+/-1.45 mM/kg wet weight for phosphomonoesters, inorganic phosphate, phosphodiesters, and phosphocreatine (PCr), respectively. These values are in good general agreement with those reported previously. Typical signal-to-noise ratios of 15:1 were obtained for PCr in spectra from nominal 31.5 cc voxel sizes with a 34-min scan time. Limits on spatial resolution and the likely error of the magnesium and pH values are discussed.

Adenosine Triphosphate↗