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Biomedical subjects

E J Duszlak

Publications and source records attributed to E J Duszlak.

9 recordsLinked to original sources

Peripancreatic lymph node enlargement in Hodgkin's disease, non-Hodgkin's lymphoma, and pancreatic carcinoma.

The distribution of enlarged lymph nodes in the upper abdomen and retroperitoneum were classified according to their relationship to the pancreas in 47 patients with non-Hodgkin's lymphoma; in nine patients with Hodgkin's disease; and in 40 patients with pancreatic carcinoma. Four patterns of lymph node enlargement were evident: (1) preaortic retropancreatic lymphadenopathy; (2) pancreaticosplenic lymphadenopathy; (3) isolated celiac and/or portal lymphadenopathy; and (4) diffuse extensive lymphadenopathy. Features differentiating lymphoma from primary pancreatic neoplasm are discussed.

Adult↗

Assessment of tumor response by computed tomography liver volumetry.

The volumes of hepatic tumors were calculated before and after therapy in 12 patients. The results were compared with clinical response, radionuclide scans, and initial qualitative computed tomography (CT) reports. A strong correlation was found between tumor volume determination and clinical response (9 of 12 patients). In only 4 of 10 patients did radionuclide scans agree with clinical response; the initial qualitative CT report disagreed with clinical response and quantitative CT response in four patients. Quantitative CT measurement was more accurate than qualitative CT evaluation and thus should be refined to offer a clinically useful addition to CT evaluation.

Follow-Up Studies↗

Peripheral hepatic artery embolization for primary and secondary hepatic neoplasms.

Eighteen patients underwent peripheral arterial embolization with Gelfoam powder for treatment of primary or metastatic hepatic neoplasms. Except for two cases in which the patients could not undergo long-term arterial infusion, all cases were treatment failures from intravenous chemotherapy, intra-arterial chemotherapy, or, in some cases, intra-arterial chemotherapy plus radiation therapy. Fourteen patients had good symptomatic relief from the procedure. Four of these patients are alive at 3, 5, 6, and 18 months following the procedure. Four patients died within 2 weeks following embolization, three of progression of disease and one of aspiration pneumonia. Of the patients showing symptomatic relief, 10 died of progression of cancer 2 to 14 months following embolization, with a median survival of 5 months. Based on the results in this small group of patients, it would seem that transcatheter hepatic dearterialization is often successful palliative therapy in patients who are not responsive to traditional therapies. Because of the low procedural morbidity, transcatheter embolization is superior to surgical dearterialization.

Carcinoma, Hepatocellular↗

Hepatic artery embolization for metastatic endocrine-secreting tumors of the pancreas. Report of two cases.

Two patients with hormone-secreting metastatic tumors of the liver (carcinoid, islet cell) were treated with transcatheter arterial embolization. In both cases, occlusion of blood supply to the tumors was accomplished, resulting in cessation of the systemic symptoms. Arterial embolization provides another useful palliative therapy for hormone-secreting tumors of the liver.

Adenoma, Islet Cell↗

CT-guided biopsy: a simplified approach.

A technique of CT-assisted biopsy using the grid reference system and light lasers is described. Ten lung and 13 abdominal biopsies were performed. Advantages of the method include simplicity, speed, and reproducibility. The advantages of CT thoracic biopsy over conventional fluoroscopy are discussed.

Biopsy, Needle↗

Dorsal diverticulum of the distal male urethra.

The lacuna magna is a congenital diverticulum embryologically arising from the dorsal aspect of the fossa navicularis. During a 1 year period, lacuna magna was diagnosed in five boys. Another 57 voiding cystourethrograms obtained in boys were reviewed retrospectively. Lacuna magna is demonstrable on properly performed voiding cystourethrography, but can be mimicked by pseudolesions created by improper radiographic technique. Clinical information, urographic evaluation, and methods of treatment are discussed.

Adolescent↗