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Biomedical subjects

E J Gutmann

Publications and source records attributed to E J Gutmann.

8 recordsLinked to original sources
PubMed1999

Much ado about doing nothing.

Negative stereotypes about certain kinds of medical specialists are commonly expressed by physicians in the presence of medical students. The authors of this brief essay, an academic pathologist and an academic internist, suggest that these sorts of remarks may have a range of deleterious effects on students. We wish to sensitize medical school faculty to this problem. Moreover, we propose that in an era in which a team approach to patient care is often required, the promotion of positive doctor-doctor relationships is critical and should be an integral part of medical education.

Education, Medical↗
PubMed1998

"No pictures from summer vacation": portrayals of pathologists in the printed media.

Public perceptions of pathologists can be shaped by individuals' direct contacts with these medical specialists, as well as by portrayals of them in the media. Few lay people, whether healthy or ill, have direct professional interaction with pathologists. Accordingly, media portrayals can assume great importance in shaping public views of pathologists and their profession. This report discusses how pathologists and the specialty of pathology are depicted in newspaper articles.

Forensic Medicine↗
PubMed1995

Syphilitic cervicitis simulating stage II cervical cancer. Report of two cases with cytologic findings.

Two women, ages 42 and 46, each had a cervical mass that clinically was grossly compatible with invasive carcinoma. Colposcopy supported the clinical impression. Weeks after the women were examined, it was determined that the masses represented syphilitic cervicitis. This entity has received almost no attention in the cytology literature, and is not discussed in major cytopathology texts. Accordingly, the cervicovaginal smears that were obtained in these cases are of interest. The smear pattern, which included lymphocytes, plasma cells, histiocytes, and debris, is described. Although in contrast, the histopathology of syphilitic cervicitis is well-characterized, diagnostic evidence of syphilis was missed in the initial interpretation of several of the biopsies. Syphilis recently has reemerged as a public health problem. Although the cases reported here represent rare events, pathologists should be aware that syphilitic cervicitis may clinically and colposcopically simulate a primary advanced cervical cancer. When interpreting cervical biopsies and cervicovaginal smears, they should be alert to patterns that suggest that syphilis is present.

Adult↗
PubMed1991

Loss of antigens associated with the apical endocytotic pathway in proximal tubules from rats with heymann nephritis.

In addition to the glomerular lesions associated with Heymann nephritis, a rat model of human membranous nephritis, proximal tubule damage, and a perturbation of proximal tubule function also have been reported to occur in this disease. The aim of the present study was to examine in more detail the nature of the apical plasma membrane damage in proximal tubules using specific antibodies directed against clathrin, gp330, and a proton-pumping adenosine triphosphatase, all of which are components of the apical endocytotic apparatus of these epithelial cells. Immunocytochemical studies revealed a marked reduction in staining for all three antigens in proximal tubules from rats with active Heymann nephritis. Furthermore endocytotic uptake of intravenously injected FITC-dextran was considerably lower in diseased animals than in normal rats. Gp330 and rat IgG were identified as components of the luminal debris that accumulated during the course of Heymann nephritis. These results show that perturbation of proximal tubule endocytosis occurs in Heymann nephritis together with a loss of three apical antigens that are normally localized on membrane domains associated with the apical endocytotic pathway in these cells. The results also suggest that antibody-antigen complexes may be shed from the plasma membrane in both the glomerulus and the proximal tubule in this disease.

Adenosine Triphosphatases↗
PubMed1989

Colchicine-induced redistribution of an apical membrane glycoprotein (gp330) in proximal tubules.

Factors governing the selective, polarized insertion of membrane proteins are poorly understood, but some studies have suggested that microtubules are involved in the generation and maintenance of cell polarity. We have examined by immunocytochemistry the effect of the microtubule-disrupting agent, colchicine, on the cellular distribution of an endogenous glycoprotein, gp330, which is normally inserted only into the apical plasma membrane of proximal tubule epithelial cells. In control rats, gp330 was localized in the brush border and in apical invaginations and vesicles. Six hours after injection of colchicine, however, vesicles containing gp330 were dispersed throughout the entire cytoplasm of the cell. Many vesicles were packed into basolateral infoldings, close to the plasma membrane, but there was no significant insertion of gp330 into the basolateral membrane. When rabbit anti-gp330 antiserum was injected intravenously into colchicine-treated rats, immune complexes appeared in the glomerular basement membrane but could not be detected in peritubular basement membranes. This supports the conclusion that colchicine treatment does not result in the insertion of gp330 into the basolateral plasma membrane of proximal tubule cells. Our results indicate that although microtubules are involved in the accumulation of gp330-containing vesicles at the apical pole of the cell, other factors must be required for fusion with the plasma membrane to occur.

Animals↗
PubMedDate not supplied

Granulomatous inflammation related to amyloid deposition in a focus of multiple myeloma. Report of a case with diagnosis by fine needle aspiration biopsy.

A 61-year-old man with no prior history of serious illness presented with a lytic rib lesion. The radiographic differential diagnosis included multiple myeloma, a metastasis and a focal infectious process, such as tuberculosis or actinomycosis. Fine needle aspiration biopsy of the mass yielded an unusual smear pattern that included small lymphocytes, plasma cells, multinucleate giant cells, granulomas and amorphous eosinophilic material. These seemingly unrelated elements suggested the possibility of a chronic inflammatory lesion of bone, such as osteomyelitis, but ultimately proved to represent multiple myeloma with granulomatous inflammation related to amyloid deposition. The case demonstrates that the differential diagnosis of chronic granulomatous inflammation with numerous plasma cells, in the appropriate clinical context, includes amyloid in association with a plasma cell dyscrasia.

Amyloidosis↗
PubMedDate not supplied

Lymphangioma presenting as a primary parotid neoplasm in an adult. Report of a case with the diagnosis suggested by fine needle aspiration biopsy.

A 38-year-old man presented with a unilateral, asymptomatic parotid gland mass. A fine needle aspiration biopsy of the mass, consisting predominantly of small lymphocytes, suggested the possibility of a lymphangioma. Microscopic examination of the subsequent parotidectomy specimen revealed a cystic lymphangioma involving the parotid gland and periparotid soft tissue. Although the presentation of a lymphangioma as a primary parotid neoplasm in an adult is a rare event, the differential diagnosis of a parotid gland aspirate containing small lymphocytes should include a lymphangioma.

Adult↗