Biomedical subjects
E J Jacobson
Publications and source records attributed to E J Jacobson.
Chronic mononucleosis--it almost never happens.
Obviously, a great deal of further research is needed into the effects of latent viral infections. A better understanding of the interaction between psychobiologic disorders and the immune system may also shed light on many of the unanswered questions concerning the role of Epstein-Barr virus (EBV) as well as other latent viruses in clinical disease. At this time, however, there is no convincing evidence that chronic EBV infection is a cause of clinical disease, except in rare instances.
Constrictive pericarditis in systemic lupus erythematosus. Demonstration of immunoglobulins in the pericardium.
A 17-year-old male with systemic lupus erythematosus presented with clinical signs of severe constrictive pericarditis that was confirmed by cardiac catheterization. At surgery, a fibrous pericardium was removed, followed by complete relief of symptoms. Immunopathology of the pericardial tissue revealed deposition of IgG, IgM, and C3. A review of the literature produced only three similar cases. Although rare, constrictive pericarditis, a potentially life threatening complication, may occur in systemic lupus erythematosus presumably with an immunological basis.