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Biomedical subjects

E J Müller

Publications and source records attributed to E J Müller.

36 records · Page 2Linked to original sources
PubMed2000

Traumatic spondylolisthesis of the axis: treatment rationale based on the stability of the different fracture types.

Thirty-nine consecutive patients, 22 male and 17 female with an average age of 37.6 years, with traumatic spondylolisthesis of the axis were reviewed. The cause of injury in 75% of the patients was a road traffic accident. The fractures were classified according to Effendi et al., the type II fractures were further divided into three subgroups: flexion, extension and listhesis injuries. There were 10 type I (25.7%) and 29 type II fractures (74.4%); of these, 12 (30.8%) were classified as flexion-type, 2 (5.1%) as extension-type and 15 (38.5%) as listhesis-type. We did not identify any case of type III injury. Overall, 43.5% of the patients had sustained a significant head or chest trauma, with the highest incidence for type II listhesis injuries. Significant neurological deficits occurred in four patients (10.3%); in all four,the fracture was classified as a type II listhesis. All ten type I injuries were successfully treated with a cervical orthosis. Ten of the 12 type II flexion injuries demonstrated significant angulation. Two were treated with internal stabilisation, in seven with a halo device and one with a minerva plaster of Paris (PoP). Healing was uneventful in all ten patients. For the remaining two stable type II flexion injuries, application of a hard collar was adequate, as was the case for the two stable type II extension injuries. Six of the 15 type II spondylolisthesis injuries underwent primary internal stabilisation, and healing was uneventful in all cases. In four (44.4%) of the nine injuries that were primarily treated with a halo device/minerva PoP, secondary operative stabilisation had to be performed. The classification of Effendi et al. provides a complete description of the different fractures. However, further distinction of the type II injuries regarding their stability is mandatory. Type II spondylolisthesis injuries are unstable, with a high number of associated injuries, a great potential for neurological compromise and significant complications associated with non-operative treatment. The majority of type II extension and type II flexion injuries can be successfully treated with nonrigid external immobilisation.

Adult↗
PubMed1999

[Surgical management of posttraumatic mal-alignments and arthroses in the ankle].

Joint incongruency, malalignement as well as degenerative changes of the ankle joint may result in disabling pain with a significant decrease in function and mobility. The clinical symptoms may affect all aspects of life. Primary osteoarthritis of the ankle joint is uncommon, and posttraumatic conditions with significant changes in joint mechanics are usually the primary source of joint degeneration with the resultant clinical symptoms. Apart from pain relief and restoration of joint mobility, prevention of joint degeneration or progression of arthrosis should be the main goal in treating such conditions. Arthrodesis of the ankle still is the method of choice for severe osteoarthritis of the ankle, however several surgical treatment options are available to deal with mild to moderate joint degeneration. Restoration of the anatomy and joint alignement in posttraumatic deformities as well as ligament reconstruction in chronic instability are measurements to prevent development or progression of osteoarthritis. Joint debridement is useful in primary anterior joint pathology, in advanced osteoarthritis at least temporary pain relief can be achieved. In severe osteoarthritis arthrodesis of the ankle is the method of choice for long-term pain relief and restoration of mobility.

Ankle Injuries↗
PubMed1999

Surgical excision of heterotopic bone after hip surgery followed by oral indomethacin application: is there a clinical benefit for the patient?

The clinical effect of surgical excision of heterotopic bone after hip surgery in combination with an oral indomethacin application was analysed in 21 patients in a retrospective study. Indomethacin (3 x 50 mg) was administered after the first postoperative day for a period of 6 weeks. To avoid gastrointestinal side-effects, a mucoprotectivum (sucralfat, 3 x 1 g) was also applied. One year after surgery, 19 patients (90.4%) had excellent relief of pain, the average improvement of flexion was 40 degrees, of abduction 13 degrees, of internal rotation 8 degrees and of external rotation 14 degrees. Only one patient (4.8%) suffered a recurrence of heterotopic bone formation, and in one patient (4.8%) we observed gastrointestinal side-effects. Thus, we recommend surgical excision of heterotopic bone followed by oral indomethacin therapy as a convenient and reliable strategy to prevent new heterotopic bone formation after hip surgery.

Adolescent↗
PubMed1999

Ipsilateral fractures of the pelvis and the femur--floating hip? A retrospective analysis of 42 cases.

A consecutive series of 40 patients, who sustained 42 ipsilateral pelvic and femoral fractures, is reported. There were eight (26.6%) traumatic neurological deficits and three open femoral fractures. Two multiply injured patients died in the postraumatic period because of the severity of their injuries. No associated vascular injuries could be identified. All but two fractures of the femur, 8 of the 15 fractures of the pelvic ring and 17 of the 30 fractures of the acetabulum were treated by internal fixation. In 26 patients internal fixation was performed on both fracture components (in 17 patients this was done under the same period of anaesthesia). Postoperatively, a deep venous thrombosis in three patients, one deep wound infection and five (18.5%) iatrogenic neurological deficits had to be notified. In this series we could not identify any specific associated injuries and complications as known for the floating knee or the floating elbow. The term floating hip is inprecise and misleading, and its use is not recommended. The treatment of this fracture-combination follows the guidelines established for the individual lesions.

Acetabulum↗
PubMed1999

Management of odontoid fractures in the elderly.

Odontoid fractures are frequent in patients over 70 years of age, and in patients over 80 years of age they form the majority of spinal fractures. In a retrospective analysis of 23 geriatric (> 70 years) patients with a fracture of the odontoid, we compared some of the clinical features to a contemporary series of patients younger than 70 years of age. Whereas in the younger patients high-energy trauma accounted for the majority of the fractures, low-energy falls were the underlying cause in 90% of the odontoid fractures in the elderly. In contrast to the younger age group, in elderly patients predominantly type II fractures (95%) were identified. Anterior and posterior displacement were recorded with equal frequency on the first postinjury radiograph in the younger age group, whereas in geriatric patients displacement was mainly posterior. The number of associated injuries was significantly higher in younger patients. There was no difference in the occurrence of neurological deficits (13%) between the two age groups, and neurological compromise was mainly related to posterior dislocation of the odontoid in both groups. The overall complication rate was significantly higher in elderly patients (52.2% vs 32.7%), with an associated in-hospital mortality of 34.8%. Loss of reduction and non-union after non-operative treatment, a complicated postoperative course and complications due to associated injuries accounted primarily for this high complication rate. Elderly patients with a fracture of the odontoid are a high-risk group with a high morbidity and mortality rate. An aggressive diagnostic approach to detect unstable fractures and application of a halo device or early primary internal stabilisation of these fractures is recommended.

Adolescent↗
PubMed1999

Anticoagulant properties, clinical efficacy and safety of efegatran, a direct thrombin inhibitor, in patients with unstable angina.

AIMS: Thrombin plays a key role in the clinical syndrome of unstable angina. We investigated the safety and efficacy of five dose levels of efegatran sulphate, a direct thrombin inhibitor, compared to heparin in patients with unstable angina. METHODS: Four hundred and thirty-two patients with unstable angina were enrolled. Five dose levels of efegatran were studied sequentially, ranging from 0.105 mg. kg(-1). h(-1)to 1.2 mg. kg(-1). h(-1)over 48 h. Safety was assessed clinically, with reference to bleeding and by measuring clinical laboratory parameters. Efficacy was assessed by the number of patients experiencing any episode of recurrent ischaemia as measured by computer-assisted continuous ECG ischaemia monitoring. Clinical end-points were: episodes of recurrent angina, myocardial infarction, coronary intervention (PTCA or CABG), and death. RESULTS: Efegatran demonstrated dose dependent ex-vivo anticoagulant activity with the highest dose level of 1.2 mg. kg(-1). h(-1)resulting in steady state mean activated partial thromboplastin time values of approximately three times baseline. Thrombin time was also increased. Neither of the efegatran doses studied were able to suppress myocardial ischaemia during continuous ECG ischaemia monitoring to a greater extent than that seen with heparin. There were no statistically significant differences in clinical outcome or major bleeding between the efegatran and heparin groups. Minor bleeding and thrombophlebitis occurred more frequently in the efegatran treated patients. CONCLUSION: Administration of efegatran sulphate at levels of at least 0.63 mg. kg(-1). h(-1)provided an anti-thrombotic effect which is at least comparable to an activated partial thromboplastin time adjusted heparin infusion. There was no excess of major bleeding. The level of thrombin inhibition by efegatran, as measured by activated partial thromboplastin time, appeared to be more stable than with heparin. Thus, like other thrombin inhibitors, efegatran sulphate is easier to administer than heparin. However, no clinical benefits of efegatran over heparin were apparent.

Adult↗
PubMed1998

[Os odontoideum. Etiology, clinical aspects, therapy].

The etiology of os odontoideum is still controversial. In most patients, it is found by accident because of neurological symptoms and/or painful range of motion of the cervical spine. Upon recognition of the os odontoideum, it is unknown whether or not immediate surgery is beneficial. This is in contrast to an "unstable" os odontoideum, which could result in atlantoaxial instability or compression of the myelon. In this study, we present the results of our treatment of four patients with an unstable os odontoideum. In all four cases, a C1-2 fusion was performed (3 x Magerl/Seemann, 1 GallieBrooks). Postoperatively, we found a complete regression of neurological symptoms in three patients and one was significantly improved. The range of motion of the cervical spine was free of pain in all patients. As a result, we strongly support immediate surgical treatment of an unstable os odontoideum in order to prevent severe and life-threatening neurological complications.

Adult↗
PubMed1998

[Subdural abscess as a complication of halo fixator].

Complications associated with the application of a halo device are not infrequent; however, osteomyelitis of the skull with a consecutive subdural abscess is a rare but severe complication. We present the case of a patient with a subdural abscess as a result of a local pin-track infection of the halo device, in whom pathological behavior was the primary clinical finding. The possible complications associated with the halo device are discussed with emphasis on associated head injuries and preexisting neurological diseases, as well as indications for the halo, clinical symptoms of pin-track infections, necessary diagnostic measurements and the appropriate treatment.

Cervical Vertebrae↗
PubMed1998

[Accident-induced pseudarthroses of the dens axis. Etiology, follow-up and therapy].

In a retrospective analysis the significance of internal fixation of unstable and symptomatic non-union of the odontoid was evaluated. In all but one cases a type II fracture of the odontoid was the underlying cause for the pseudarthrosis. The time interval between trauma and definitive diagnosis varied between 6 months and 30 years. All patients asked for medical advice because of acute neck pain; in three cases additional neurological deficits were notified. In all but one case the pseudarthrosis was classified as unstable on flexion-/extension views. The occurrence of neurological deficits showed a positive correlation with the amount of dislocation of the pseudarthrotic odontoid. Nine out of 10 patients underwent internal stabilisation of the non-union. Reoperation because of persistent instability/failure of stabilisation had to be performed in two cases (22.2%). At follow-up all 9 patients were pain-free. The neurological deficits in two patients had improved significantly. According to our experience internal stabilisation in unstable non-union of the odontoid is recommended to achieve significant reduction of the pain level. Also improvement of the neurological deficits can be expected depending on the duration of the symptoms.

Adolescent↗
PubMed1998

[Prostheses of the head of the radius. What outcome can be expected?].

We report our results after primary implantation of 30 radial head prostheses in a retrospective study from 1978 to 1996. If there was intraoperatively a remaining instability of the elbow after resection of the radial head, we implanted a prosthesis. The average age of our patients was 40.7 years. The results were evaluated concerning the recommendations of Radin and Riseborough. In 22 patients (73%) we found good to satisfactory results, in 8 patients (27%), there was a free range of motion. Heterotopic ossifications with a remarkable decrease in the range of motion were discovered in 3 patients (10%). The implant had to be removed in three (10%) patients (2 incorrect implantations, one broken prosthesis). To conclude, the primary implantation of a radial head prosthesis after a strict indication improves the clinical benefit for the patient. A correct surgical technique avoids unnecessary complications.

Adult↗
PubMed1998

The motorcyclist: easy rider or easy victim? An analysis of motorcycle accidents in Germany.

This report reviews the findings from 86 motorcycle accidents during a 1-year period at the Trauma Center "Bergmannsheil" in Bochum, Germany. A study of the case histories supplemented by telephone conversations yielded the following results: 90.7% of the patients were men, and the average age was 28.8 years; most of the accidents occurred in the 25- to 30-year-old age group (27.9%). Motorcycle accidents happened mostly during recreational rides on weekends in the summertime. Although there was a high rate of helmet use (98.8%), the head region was affected in 12 victims. Two patients died because of their severe head injuries (2.3%). Lower extremity injuries (46%), especially open tibia fractures (19.7%), were among the most common injuries sustained. Fractures of the distal radius constituted the largest portion of upper extremity injuries (18.8%). The average stay in our hospital was 35.4 days; 23.4% of the patients had to change jobs after the accident. Fifty percent of the crashes happened with motorcycles between 500 and 750 cc stroke volume. Although 34.5% possessed their driver's licenses for more than 8 years, they had not had much experience handling a motorbike. These results underline the fact that motorcycle accidents are sustained by young men in their working prime; as a result, these accidents pose a tremendous burden to individuals and society and every attempt should be made to offer highly qualified surgical and trauma care to minimize the damage to the motorbiker. A plea is made for more prevention measures like driver education, better road conditions, or legislative changes to prevent motorcycle crashes. The wearing of a helmet is strongly advocated.

Accidents, Traffic↗
PubMed1997

[Missed diagnosis in delayed recognition of bilateral simultaneous rupture of the quadriceps tendons].

In this article we report a very rare case of simultaneous and bilateral rupture of the quadriceps tendon in a 38-year-old patient. The initial diagnosis was "herniated vertebral disk". Although there was an extensive neurological and psychiatric examination in combination with several operations, it took almost 3 months until the real reason was found. In this case report we describe our postoperative treatment of early mobilization and compare it with other therapies.

Adult↗
PubMed1997

Comparison of usefulness of computer assisted continuous 48-h 3-lead with 12-lead ECG ischaemia monitoring for detection and quantitation of ischaemia in patients with unstable angina.

AIMS: The selection of ECG leads used for ST monitoring may influence detection and quantitation of ischaemia. METHODS: We compared on-line continuous 48-h 12-lead against 3-lead ST monitoring in 130 unstable angina patients (Mortara. ELI-100). Onset and offset of ST episodes were defined by the lead with the first > or = 100 microV ST change relative to baseline and the lead with the latest return to baseline ST level, respectively. ST episodes were calculated for 12 leads and 3 leads (V2, V5, III) separately. RESULTS: ST episodes were detected in 88 patients (77%) by 12-lead and in 71 patients (62%) by 3-lead ST monitoring (P < 0.02). The median number (25.75%) of episodes/patient was 1 (0.3) for 3-lead and 2 (1.6) for 12-lead (P < 0.0001). The total duration of ischaemia detected during 12-lead far exceeded 3-lead monitoring: 12.3 (1, 58.2) and 1.7 (0, 23.3) min respectively (P < 0.0001). The probability of recurrent ischaemia declined most during the first 24 h of monitoring. After a period without ST changes of 1, 12, 24 and 36 h, the probabilities of recurrent ischaemia were 63, 31, 14 and 9%, respectively. CONCLUSIONS: Continuous 12-lead ST monitoring increases detection rate and duration of ST episodes compared to 3-lead ST monitoring. The use of continuous 12-lead ECG monitoring devices on emergency wards and coronary care units is recommended.

Angina, Unstable↗
PubMed1987

Activation of the fibrinolytic system during intracoronary streptokinase administration.

Serial biochemical studies were performed in 12 patients treated with intracoronary streptokinase infusion for acute myocardial infarction, in order to study the method of activation of the fibrinolytic system during local administration of a relatively low dose of this drug and to determine correlations between systemic effects and reperfusion. Plasma samples were obtained before and every 15 minutes during the infusion of streptokinase and after completion of the therapy. Streptokinase dosage in this study was 211,000 +/- 88,000 IU (+/- SD). The average time from the onset of symptoms to the start of infusion was 2 hours 50 minutes (range 1 hour 10 minutes to 3 hours 30 minutes). Reperfusion occurred in six patients and temporary recanalization in three; in three patients no recanalization was achieved. Fibrinolytic assays of pretreatment plasma samples revealed elevated levels of plasminogen activators, presumably caused by the release of tissue-type plasminogen activator after a condition of stress. Plasminogen concentrations decreased from 94 +/- 17% to 44 +/- 30%. Alpha 2-antiplasmin fell from 84 +/- 27% to 12 +/- 19%; in seven patients no plasmin inhibitor activity was measurable at the completion of the infusion. Free plasmin occurred in samples only when this inhibitor had disappeared. This resulted in a lytic state leading to degradation of fibrinogen, the levels of which fell from 2.9 +/- 0.7% to 1.5 +/- 1.1%. Fibrinogen degradation products, measured in plasma with monoclonal antibodies, increased exponentially during streptokinase infusion in at least four patients.(ABSTRACT TRUNCATED AT 250 WORDS)

Coronary Vessels↗
PubMedDate not supplied

[Spinal contusion after trauma to the cervical spine--relevance of the sagittal diameter of the spinal canal].

PURPOSE: The purpose of this study was to analyze the relationship between spinal stenosis and cervical myelopathy. Furthermore it was to investigate whether there is a correlation between spinal stenosis and progression of neurologic symptoms? PATIENTS AND METHODS: Using the Pavlov ratio method, we compared 14 patients with a contusio spinalis with 14 patients who suffered from a distortion of the cervical spine. This ratio is calculated by the sagittal diameter of the spinal canal with the anteroposterior width of the vertebral body. RESULTS: In eight patients with a contusio spinalis, there was a spinal stenosis, while there was none in the distortion group. The remaining patients with a contusio had severe degenerative changes in routine roentgenograms of the cervical spine. The Pavlov ratio was statistically significant reduced in the contusio group. After 8.5 days there was a complete regression of neurologic symptoms, whereas in 4 patients there was no full recovery. CONCLUSION: To conclude we demonstrated that a spinal stenosis promotes a contusio spinalis but there is no evidence that the Pavlov ratio allows statements concerning the progression of the injury.

Adolescent↗