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Biomedical subjects

E J Mulder

Publications and source records attributed to E J Mulder.

At least 37 records · Page 2Linked to original sources
PubMed1997

The effects of maternal exercise on fetal heart rate and movement patterns.

The aim of this study was to investigate the effects of maternal exercise on fetal movement and heart rate patterns. Twelve healthy women at 29-32 weeks of pregnancy performed a (sub)maximal bicycle exercise test, reaching 53-99% (median 82%) of their maximal increase in heart rate (MIHR). Fetal heart rate (FHR) and its variation and fetal body and breathing movements were recorded for 1 h before and after the exercise and also on a control day. After exercise, FHR was higher for 30 min and FHR variation reduced for 20 min as compared with pre-exercise levels (P < 0.01). Fetal body movements were reduced for the first 5 min following exercise (P < 0.05). In two cases, fetal bradycardia was observed (at 89 and 99% MIHR) followed by a considerable reduction in FHR variation and absence of body and breathing movements for 20 min. In the other 10 fetuses fetal breathing activity was increased for the first 5 min after exercise (P < 0.05). FHR (and to a lesser extent breathing movements) increased with increasing level of maternal exercise, but decreased when the % MIHR exceeded approximately 90%. Body movements were negatively correlated with the % MIHR (P < 0.05). In conclusion, moderate to heavy maternal exercise clearly affects the human fetus with signs of transient fetal impairment after heavy exercise.

Adult↗
PubMed1997

Laparoscopic surgery in Crohn's disease.

In a prospective study the feasibility and safety of laparoscopic-assisted ileocaecal resection for Crohn's disease was studied and compared with 16 patients who had open ileocaecal resection, and the value of laparoscopic stoma surgery was assessed. From January to November 1995 laparoscopic-assisted ileocaecal resection for Crohn's disease was undertaken in 7 patients, laparoscopic-assisted stoma formation in 10 patients. In 1 patient laparoscopic ileocaecal resection was converted to open surgery due to an unrecognised ileocolic fistula. Operating time in laparoscopic-assisted ileocaecal resections was longer than in open ileocaecal resection (150 vs. 127 min, P = 0.7). Blood loss (386 vs. 445 ml, P = 0.7), first bowel movement (3.5 vs. 4.9 postoperative days, P = 0.07) and postoperative time to discharge (5.2 vs. 9.9 days, P < 0.01) in patients who had a laparoscopic-assisted ileocaecal resection were less than in patients who had open surgery. In all 10 patients laparoscopic formation of a stoma was possible. Operating time was 62 min. Oral solids were restored on the 1.5 postoperative day. Mean postoperative stay was 8.8 days, prolonged due to time needed for stoma-care training. These preliminary results indicate that laparoscopic-assisted ileocaecal resection and stoma surgery for Crohn's disease are feasible and safe. Both procedures are characterised by rapid recovery and superior cosmetic results.

Adult↗
PubMed1997

Antenatal corticosteroid therapy and fetal behaviour: a randomised study of the effects of betamethasone and dexamethasone.

OBJECTIVES: To compare the effects of maternal betamethasone and dexamethasone administration on fetal behaviour and fetal heart rate variation. DESIGN: A prospective randomised study of 60 women at increased risk of preterm delivery. OUTCOME MEASURES: Fetal heart rate and its variation, the incidence of fetal body and breathing movements. SETTING: Obstetric unit, University Hospital, Utrecht, The Netherlands. RESULTS: Following maternal betamethasone administration (day 2), fetal heart rate variation was reduced by 19% and fetal body and breathing movements by 49% and 85%, respectively. After dexamethasone treatment there was a significant increase in short term fetal heart rate variation (24%) on day 1. All values returned to baseline on day 4, indicating that no fetal deterioration had occurred during the course of the study period. CONCLUSION: Betamethasone, with probably the greater beneficial effect, has more effects on fetal behaviour and fetal heart rate variation than dexamethasone. When assessing fetal condition, due account needs to be taken of these effects.

Betamethasone↗
PubMed1997

Noninvasive monitoring of fetal heart rate during the last ten days of gestation in sows.

OBJECTIVE: To develop and evaluate a noninvasive technique for monitoring and analyzing porcine fetal heart rate (FHR) during late gestation. ANIMALS: 8 fetuses of 8 pluriparous sows in late gestation. PROCEDURE: With the sow positioned in lateral recumbency, the most caudal fetus was identified, using real time ultrasonography, and its heart rate was recorded for 60 minutes by use of Doppler cardiography. The same fetus was identified and monitored repeatedly during the last 10 days of gestation, excluding the 24 hours before delivery. Visual inspection and computerized analysis of the recordings were performed. RESULTS: 66 one-hour recordings were obtained from 8 fetuses, 1 in each of 8 sows. Mean signal loss was 37.5%. Episodes of low FHR and low FHR variation (FHR pattern A) alternated with episodes of high FHR and high FHR variation (FHR pattern B). This cyclic alternation between 2 distinct. FHR patterns was observed in 46 of 66 (69.7%) recordings, and suggests the presence of different behavioral states in fetal pigs. Basal FHR decreased toward parturition in 7 fetuses, but increased in 1 fetus with abdominal ascites. Basal FHR and long-term FHR variation were negatively correlated (r[S] = -0.73; P < 0.001). CONCLUSION: Noninvasive monitoring of FHR is possible and feasible during late gestation in pigs. This method permits longitudinal studies under pathophysiologic conditions and the evaluation of the effects of endogenous and exogenous influences on porcine FHR.

Animals↗
PubMed1996

Investigating the effect of maternal alcohol intake on human fetal breathing rate using adaptive time-frequency analysis methods.

In this study, the matching pursuit (MP) method which is a modified version of the wavelet transform (WT) method was proposed to examine the effects of alcohol on human fetal breathing rates in both time and frequency domains. The matching pursuit method was chosen since the classical Fourier transform may not represent signals which have stationary characteristics and wavelet transform may not represent signals whose Fourier transforms have a narrow frequency support. Our results show that the horizontal structured atoms representing the sinusoidal activity at all frequency ranges disappeared and the vertical structured atoms representing the discontinuous spike type activity increased. In addition, the circular structured atoms at the high frequency range shifted to the low frequencies after the alcohol intake. The results also suggested that the matching pursuit is most suitable for analyzing the fetal breathing rate signals with and without alcohol intake.

Algorithms↗
PubMed1996

Absence of significant hemodynamic changes in the fetus following maternal betamethasone administration.

Maternal betamethasone administration causes a transient but considerable reduction in fetal body and breathing movements and in fetal heart rate variation. The aim of the present prospective study was to investigate whether there is evidence of circulatory changes in fetal, placental or uterine arteries, consistent with hypoxemia. Eighteen women at risk for preterm delivery received betamethasone to enhance fetal lung maturation. Doppler studies were performed before treatment, and 24 and 72 h after the second dose of betamethasone. Blood flow velocity waveforms were obtained from both uterine arteries, umbilical arteries, fetal descending aorta, fetal renal artery, and fetal cerebral arteries. No significant changes occurred in the pulsatility index of any of these blood vessels, suggesting that the transient reduction in fetal heart rate variation and fetal body and breathing movements following maternal betamethasone administration is not mediated through fetal hypoxemia.

Adult↗
PubMed1995

Fetal breathing movements in late diabetic pregnancy: relationship to fetal heart rate patterns and Braxton Hicks' contractions.

In type-1 diabetic pregnancy, the occurrence of fetal breathing movements (FBM) was studied in relation to the fetal heart rate patterns (HRPs) A and B and to Braxton Hicks' contractions. Simultaneous 2-h recordings of fetal heart rate and body, eye and breathing movements were available for analysis (n = 44). These recordings were made in 20 fetuses of diabetic women at 32-38 weeks of gestation. Uterine activity was monitored at 36 and 38 weeks. For all recordings combined, the median incidences of FBM during HRPs A and B were 23% and 41%, respectively (NS). At low overall breathing activity (< 50% of total observation time), FBM were more numerous during HRP B than during HRP A in 83% of the recordings. However, if the overall breathing activity exceeded 50% of time FBM were preferentially made during HRP A in 93% of the recordings. This relationship was most pronounced at 38 weeks. These results corroborate our previous findings in the healthy near-term fetus. They show even more clearly that the state-dependent occurrence of FBM depends on the fetus' drive to breathe. During the recordings, breathing activity remained unchanged at all gestational ages studied, in contrast to the gradual decline in FBM seen in normal pregnancy. Braxton Hicks's contractions had no effect on FBM, which differs from the specific distribution of FBM during uterine contractions as previously found in uncomplicated pregnancies. We conclude that FBM in late diabetic pregnancy are not influenced by Braxton Hicks' contractions and that they do not show a clear-cut state-dependency. The (neural) mechanism underlying FBM differs from that in normal pregnancy.

Diabetes Mellitus, Type 1↗
PubMed1995

The effects of maternal betamethasone administration on the fetus.

OBJECTIVE: To examine prospectively the effects of maternal betamethasone administration on fetal heart rate variation, body, breathing and eye movements and the rest-activity cycle. DESIGN: Thirty-one women on 38 occasions were at risk of premature delivery and received two doses of betamethasone 24 h apart. Gestational age ranged between 26 and 32 weeks. Fetal heart rate was monitored on each of five successive days (0-4) and fetal body, breathing and eye movements were recorded on days 0, 2 and 4. RESULTS: Compared with the control day before steroid administration (day 0), both long term and short term fetal heart rate variation were reduced on days 2 and 3 (P < 0.01). In one-third of the cases, fetal heart rate variation fell transiently below the lower normal range for gestational age. Body movements were reduced on day 2 by 50% (P < 0.01) due to prolonged periods of inactivity (P < 0.01). Breathing movements were largely absent on day 2 (P < 0.01), but the occurrence of eye movements remained unchanged after betamethasone administration. All values returned to baseline on day 4, indicating that no fetal deterioration had occurred during the course of the study period. Similar responses to betamethasone were observed in five fetuses when studied at re-presentation two weeks later. CONCLUSIONS: Maternal betamethasone administration causes a considerable but transient reduction in fetal body movements and activity periods, breathing and heart rate variation, without affecting fetal eye movements. Knowledge of this phenomenon is important when assessing the fetal condition. The effect may be due to a glucocorticoid receptor mediated process in the fetal brain.

Betamethasone↗
PubMed1994

Transient reduction in fetal activity and heart rate variation after maternal betamethasone administration.

We studied the short-term effects of maternal betamethasone administration on fetal well-being by recording of fetal movement and heart rate patterns. In 13 women at high risk of preterm delivery (26-32 weeks), eighty 1-h recordings were made of fetal body and breathing movements and fetal heart rate (FHR) and its variation during 5 consecutive days. Betamethasone was administered in two doses 24 h apart after a control recording had been made. After two doses of betamethasone, fetal body and breathing movements and FHR variation were considerably reduced (P < 0.01), but returned to normal after treatment was discontinued. FHR variation was transiently below the lower normal range in 46% of the cases. We conclude that maternal betamethasone administration results in a considerable reduction in fetal movements and FHR variation which may erroneously be interpreted as deterioration of the fetal condition. Knowledge of these transient changes is of significant clinical importance as it may prevent iatrogenic delivery because of suspected fetal distress. The observed effects are possibly mediated by centrally located glucocorticoid receptors.

Betamethasone↗
PubMed1994

Patterns of breathing movements in the near-term human fetus: relationship to behavioural states.

The occurrence of fetal breathing movements was studied in relation to fetal behavioural states 1F and 2F, as recognized by the heart rate patterns A and B, respectively. Simultaneous recordings of fetal heart rate and body, eye and breathing movements were available for analysis (n = 88). These recordings, lasting > or = 2 h, had been made in healthy near-term fetuses during the afternoon or evening, starting about 1 h after the maternal meal. In the majority of recordings fetal breathing activity was lower during heart rate pattern A than during pattern B, but as the opposite occurred in 29/88 recordings (33%), the interstate difference was not significant (P = 0.052). Detailed analysis revealed that breathing movements were more numerous during pattern B than during pattern A if the incidence of breathing during a particular time period was low (30-40% of time). At a high overall breathing incidence (> 40%), however, breathing movements were more often present during pattern A than during pattern B. The latter occurred especially in the first hour of recording, i.e. less distant in time from maternal meals. We conclude that fetal breathing activity is generally higher during state 2F than during state 1F, but a clear-cut state-dependency is absent. Secondly, the relationship between the incidences of breathing during states 1F and 2F depends on the 'drive' or motivation (presumably the blood glucose content) to breathe.

Female↗
PubMed1993

The effect of vibro-acoustic stimulation on fetal behavioral state organization.

During the third trimester of pregnancy there is a gradual development of fetal behavioral states. These states are distinct and discontinuous modes of neural activity; they reflect a certain degree of maturity and/or integrity of the fetal brain and are homologous with those seen in newborn infants. Abnormal state development has been found in growth retarded fetuses and in fetuses of women with type-1 diabetes. Behavioral state organization is not easily influenced by external factors and most stimuli fail to induce a state change when the fetus is in quiet sleep (state 1F). However, fetuses do react to vibro-acoustic stimulation (VAS) with an electronic artificial larynx. This stimulus induces excessive fetal movements, prolonged tachycardia, disorganization of behavioral states, and state transitions normally not seen in healthy fetuses. The backgrounds for these excessive and unusual reactions are largely unknown. For the time being, it seems better not to use this device in clinical practice. In this review paper, data on the development of behavioral states and on fetal reactions to VAS are discussed.

Acoustic Stimulation↗
PubMed1993

Heart rate variation during fetal behavioural states 1 and 2.

Fetal heart rate (FHR) variation was numerically assessed in relation to behavioural states in 34 normal near term fetuses, in order to study the normal ranges of FHR variation during state 1F and 2F and to determine possible factors influencing variation in these states. In all individuals 2-h recordings were made of fetal heart rate, and body and eye movements. FHR variation was quantified using the Sonicaid System 8000. During both 1F and 2F there was a large range in variation, with a wide overlap in variation between both states (mean 1-min range in pulse intervals 16-53 ms and 36-97 ms, respectively). In all fetuses variation was higher during 2F than during 1F. The large ranges in variation were mainly caused by differences in basal heart rate and the correlation coefficients between rate (beats/min) and variation were -0.68 and -0.49 for 1F and 2F, respectively. Other reasons for a relatively high FHR variation during 1F included 'pseudo' sinusoidal patterns related to fetal sucking or mouth movements and relatively flat periods sporadically interrupted by an acceleration. With the System 8000, periods of low and high variation are identified using fixed criteria. Because of the large overlap in variation between both states, these episodes poorly correlated with the underlying behavioural states. Objective identification of the heart rate patterns during states 1F and 2F requires incorporation of heart rate itself in the analysis. As yet, 'global' visual identification of heart rate patterns is superior to computer analysis in identifying the underlying fetal behavioural states.

Behavior↗
PubMed1993

Changes with time in fetal heart rate variation, movement incidences and haemodynamics in intrauterine growth retarded fetuses: a longitudinal approach to the assessment of fetal well being.

Fetal heart rate (FHR) variation, general movements (FGM), breathing movements (FBM) and haemodynamics were studied longitudinally in 19 intrauterine growth retarded fetuses, who eventually were delivered by caesarean section (CS) because of fetal distress, in order to determine changes occurring with time. The fetuses were studied for the last 10 days on average before delivery (range 2-14 days). During this period on average eight 1-h FHR records were made and three 1-h movement recordings. The FHR pattern was analyzed numerically; the incidence of FGM and FBM was quantified and expressed as percentage of time. Blood flow velocity waveforms were measured in the umbilical artery (n = 19) and in the internal carotid artery (n = 14). In 14 of 19 fetuses abnormal velocity wave forms were present from the beginning of the study onwards. FHR variation was initially just within or below the norm and fell further during the last 2 days before CS. FGM and FBM fell below the normal range later and in a lower rate of occurrence than FHR variation. FGM showed a more or less consistent fall in time, whereas FBM showed a wide range throughout the period of observation. The poorest outcome occurred in fetuses with reversed end-diastolic velocities and rapid fall in FHR variation. It is concluded that with progressive deterioration of the fetal condition abnormal velocity wave form patterns occur first; FHR variation is reduced subsequently and FGM and FBM are the last to become abnormal. Assessment of fetal activity may be of help in fetuses with a marginally reduced FHR variation, in which prolongation of pregnancy is considered desirable to allow further maturation in utero.

Adult↗
PubMed1992

Numeric analysis of heart rate variation in intrauterine growth-retarded fetuses: a longitudinal study.

OBJECTIVE: We attempted to determine changes occurring with time in fetal heart rate and its variation in fetuses with intrauterine growth retardation in whom late antepartum fetal heart rate decelerations eventually develop. STUDY DESIGN: Thirteen fetuses with intrauterine growth retardation were studied over a median period of 25 days. One-hour fetal heart rate records were made two to five times per week and were analyzed numerically. Fetal movements were recorded by the women. RESULTS: On average long-term fetal heart rate variation decreased gradually with time and fell below the norm (30 milliseconds) at about the same time decelerations appeared. Mean heart rate showed a slight but statistically significant increase after the occurrence of decelerations. There were large interfetal differences in all parameters studied. CONCLUSION: In fetuses with intrauterine growth retardation a decrease in long-term fetal heart rate variation is a rather late sign of impairment that coincides with the occurrence of late decelerations. In the surveillance of the fetus with intrauterine growth retardation it might be most appropriate to use each fetus as its own control.

Female↗
PubMed1992

Impact of early growth delay on subsequent fetal growth and functional development: a study on diabetic pregnancy.

In the first trimester of type-1 diabetic pregnancy, the embryo and fetus are often smaller than normal (early growth delay). We examined the impact of early growth delay on subsequent growth (birth weight) and functional development near term (organizational level of fetal behavioral states) in 21 and 10 fetuses of diabetic women, respectively. There was no relationship between the degree of early growth delay and birth weight (centiles). Mean growth delay per fetus in early diabetic pregnancy was negatively correlated with the occurrence of no-coincidence between behavioral state parameters at 36 weeks (R = -0.59; P < 0.05). These results indicate that disorders occurring in early life may underlie abnormal functional development in later life, whereas (catch up) growth is mainly determined during the second half of pregnancy.

Birth Weight↗
PubMed1992

Studies on developmental neurology in the human fetus.

The development of the motor component of the embryonic and fetal central nervous system can be studied by observation of fetal movements, using real-time ultrasound. In this paper data on emergence and development of fetal movement patterns and behavioural states are reviewed in the light of the normal development of the nervous system, identification of disturbances in normal development and testing behavioural teratogenicity in the human.

Embryonic and Fetal Development↗
PubMed1991

Growth and motor development in fetuses of women with type-1 diabetes. I. Early growth patterns.

Early embryonic and fetal growth were followed longitudinally in 23 women with type-1 diabetes to investigate whether there was any evidence of early growth delay and, if so, when it originated and when catch-up growth occurred. Weekly crown-rump length (CRL) measurements were taken between 7 and 14 weeks of gestation; the biparietal diameter (BPD) of the fetal head was measured once every 2-4 weeks from 13 to 30 weeks of gestation. Data were compared to those of a control group and to control data published in the literature. The CRL of the fetuses in the diabetic group was generally shorter than that observed normally. Six out of the 23 (26%) fetuses showed true early growth delay (a size smaller than normal by 6 days or more). Growth delay was present from the first recording onwards and must therefore have occurred before the seventh gestational week. Fetal growth (BPD) was found to be normal at around 20 weeks and there was evidence of accelerated growth of the BPD during the second trimester in fetuses that became macrosomic. Early embryonic growth delay was most profound in the women whose periconceptional quality of glucose control was poor, although the relationship with the HbAlc values was not statistically significant. It is concluded that fetuses of women with type-1 diabetes, as a group, have a significantly different growth pattern than control fetuses throughout the first 30 weeks of pregnancy.

Adult↗