Detection of a conformational change in maltose binding protein by (129)Xe NMR spectroscopy.
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ATP-Binding Cassette Transporters↗
Biomedical subjects
E J Ruiz
Publications and source records attributed to E J Ruiz.
Functionalized xenon as a biosensor.
The detection of biological molecules and their interactions is a significant component of modern biomedical research. In current biosensor technologies, simultaneous detection is limited to a small number of analytes by the spectral overlap of their signals. We have developed an NMR-based xenon biosensor that capitalizes on the enhanced signal-to-noise, spectral simplicity, and chemical-shift sensitivity of laser-polarized xenon to detect specific biomolecules at the level of tens of nanomoles. We present results using xenon "functionalized" by a biotin-modified supramolecular cage to detect biotin-avidin binding. This biosensor methodology can be extended to a multiplexing assay for multiple analytes.
Avidin↗
Influence of bilingualism on communication in groups.
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Communication↗