Biomedical subjects
E J Stay
Publications and source records attributed to E J Stay.
Gravidic macromastia: case report.
Gravidic macromastia is a rare condition. Breast enlargement in pregnancy is influenced by several hormones, including ovarian steroids and somatotropic or lactogenic polypeptide hormone. Evaluation showed minimal reactive stromal and periductal fibrosis. The treatment is surgical.
Correlation of xeroradiography and histology of breast disease.
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The relationship between nephroblastoma and neurofibromatosis (Von Recklinghausen's disease).
Three cases with co-existent Wilm's tumor and Von Recklinghausen's Disease from a series of 342 nephroblastomas are discussed as to the significance of this association. Biological arguments favor a positive link because of the multiplicity of associative lesions which parallel each other, the co-existence of which suggests a common genetic bond. An embryologic association is described whereby early mutational events, i.e. neural induction of nephrogenesis, may link these two entities in utero. Further interconnection is stated statistically, in that nephroblastoma patients in this series had a 29 fold higher incidence of multiple neurofibromatosis than predicted for in the general population. The co-existent diseases in the three cases observed are approximately 33-50% more than can be accounted for by chance in the United States population. Malignant transformation in neurofibromatosis is discussed because of the therapeutic implications presented by two of the three Wilms' tumor patients studied.
Chondroma. An unusual presentation of an extraarticular soft tissue mass about the knee.
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Ovarian tumors in pregnancy. A community hospital's five year experience.
Ovarian tumor in pregnancy is a distressing problem for the obstetrician. A physician must differentiate between a manifestation of a normal physiological condition and a serious pathological condition. Fortunately an ovarian tumor in pregnancy is rare. Once the condition is suspected, a physician should use all available tools to confirm the diagnosis. A patient should be treated accordingly, keeping in mind the age of the patient, the gestational age, and the biology of different types of the tumor.