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Biomedical subjects

E Jäggi

Publications and source records attributed to E Jäggi.

3 recordsLinked to original sources
PubMed1997

Dilated cardiomyopathy and thrombo-embolism.

UNLABELLED: The purpose of this study was to investigate the incidence, outcome and prevention of thrombo-embolism in children with dilated cardiomyopathy. From 130 patients with dilated cardiomyopathy, 17 (14%) showed evidence of thrombo-embolism. Seven had initial cardiac thrombus, 7 exhibited initial embolus and in 3 thrombo-embolism was only diagnosed at autopsy. All 17 patients showed seriously impaired systolic function of the left ventricle with fractional shortening (FS) of 10 +/- 3%, range 5%-17%, as compared to those without thrombo-embolism with FS of 17% +/- 6%, range 5%-26% (P < 0.0001). Seven patients were treated with oral anticoagulants once thrombo-embolism had been diagnosed; one of them experienced a further embolic event as opposed to three out of four patients not treated with anticoagulants. CONCLUSION: All children with dilated cardiomyopathy and fractional shortening below 20% should be treated with prophylactic anticoagulative agents.

Adolescent↗
PubMed1988

[Intensified insulin therapy in Type 1 diabetes. Results of a 1-year treatment using the basic-bolus principle in hard-to-control diabetic patients].

Thirty-six adult type 1 diabetics, whose metabolic control was unsatisfactory on conventional insulin treatment or on continuous subcutaneous insulin infusion, were treated for an average of 13 months by the basis-bolus insulin regimen using pen-like insulin injectors. HbAlc-values improved from 8.1% before to 6.7% at the end of the observation period, with the same daily injected amount of insulin (39 +/- 2 IU/d before, 38.7 +/- 2 IU/d after switching to the new regimen). The number of hypoglycemic events did not increase with the new insulin regimen. Acceptability was good. Flexibility as to the timing of meals and easy handling of the device were considered the main advantages of the new system. Some patients were bothered by the need for intensified self-monitoring of blood glucose. The insulin regimen according to the basis-bolus principle using pen-like injectors led to an improvement of both metabolic control of the patients and their quality of life. It is, however, mandatory that they are properly instructed and willing to perform regular home monitoring of blood glucose.

Adult↗