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E Jagiełło

Publications and source records attributed to E Jagiełło.

3 recordsLinked to original sources
PubMed1997

[The role of genetic factors, apoptosis and 14-3-3 protein in induction of atopic diseases].

In this review we try to summarize some of the new informations about the genetic base of bronchial asthma. We also mention apoptosis (programmed cell death) as the process modulating cell proliferation, differentiation and death. According to the latest reports, the disorders of the regulation of apoptosis may play an important role an the pathogenesis of autoimmune and atopic diseases (including bronchial asthma), AIDS and neoplastic diseases. There is a linkage between the induction of apoptosis and signal transduction disorders. We describe the Raf/MECK/ERK/MAP signal transduction pathway and 14-3-3 protein--the peptide which possibly might participate in the initiation of the programmed cell death.

14-3-3 Proteins↗
PubMed1994

[The effect of inhaling pirenzepine--selective M1 receptor antagonist and ipratropium bromide on lung ventilation in patients with bronchial asthma].

The study was carried out on 19 patients with moderate and severe bronchial asthma. During three days after the initial spirometric evaluation the patients received--on the first day 0.5 mg of pirenzepine in nebulization (P), on the second day 0.25 mg of ipratropium bromide (IB), on the third day both substances together. Ventilatory parameters were monitored on the 5th, 20th, 40th and 60th minute following nebulization. The observed parameters did not differ significantly between both groups. Pirenzepine given after ipratropium bromide increased FEV1 from 1.89 L to 2.37 L (p < 0.01). The observed results imply that pirenzepine given with ipratropium bromide induce a significant bronchodilating effect and could be added to therapy of bronchial asthma.

Administration, Inhalation↗