PubMed Health⌕ Search

Biomedical subjects

E Jehle

Publications and source records attributed to E Jehle.

7 recordsLinked to original sources
PubMed1996

[Evaluating elective surgical procedures in ulcer surgery].

Elective surgical treatment of peptic ulcers is less important after the introduction of effective conservative treatment. However, in a chronic recurrent disease all options of treatment have a place. In duodenal ulcer highly selective vagotomy is the procedure of choice despite the high recurrence rate, since it has a low operative risk and a low rate of early postoperative morbidity or late sequelae. In gastric ulcer distal partial gastrectomy (Billroth I) must be recommended using the same criteria. Laparoscopic techniques will not alter the indication for surgery; these procedures are still hampered by technical problems and the main problem of high recurrence rate after vagotomy is not solved by choosing a different approach to the abdomen. Surgical treatment of peptic ulcers must be revalidated in respect to health care reform.

Gastrectomy↗
PubMed1994

[The MR tomography of focal liver lesions with the superparamagnetic contrast agent AMI-25 at 1.5 tesla].

Superparamagnetic iron oxide particles (AMI-25) were evaluated as a liver contrast agent in high-field MR imaging (1.5 T). 16 patients with up to 5 presumed focal liver lesions (liver metastases n = 8, HCC n = 5, Klatskin tumours n = 2, FNH n = 1) received 15 mumol Fe/kg BW intravenously and were examined via standard T1- and T2-weighted spin-echo sequences. Quantitative image analysis showed a post-contrast increase of the contrast-to-noise ratio (C/N) from 1.6 to 7.4 on SE 2,500/15 images (p < .05). However, C/N was in the same range on plain SE 2,500/90 scans. Blind evaluation by two independent readers revealed that AMI-25-enhanced images did not provide a significantly increased number of lesions. Two patients reported minor, self-limited side-effects (flush, back pain). We conclude that in contrast to reports at mid-field MR imagers, the use of AMI-25 at 1.5 T does not significantly improve the detection of focal liver lesions on conventional SE images.

Adult↗
PubMed1994

[Evacuation proctography: physiological variability and clinical relevance of the anorectal angle and the position of the pelvic floor].

Evacuation proctography is an important imaging method for the investigation of abnormalities of defecation. For this procedure, the most commonly carried out measurements are the ano-rectal angle and the position of the pelvic floor. The given mean values and the physiologically acceptable deviations vary just as much as the perceived clinical value of these measurements. 173 evacuation proctograms were evaluated in a prospective study; the subjective abnormalities were correlated with clinical findings. No significant correlation between the measurements from the proctograms and the clinical findings could be determined. The clinical relevance of these measurements is, therefore, uncertain.

Adult↗
PubMed1991

[Prognostic factors in Crohn's disease. Is the probability of a later operation assessable at the initial diagnosis?].

Data were retrospectively analysed of 492 patients (268 women, 224 men; mean age 27 [9-71] years) to find out what features present at time of first diagnosis (age, sex, site of disease, biochemical findings) will play a role in determining the probability of surgery ultimately becoming necessary. The probability of an operation ten years after first diagnosis was 55%, after 20 years it was 88%, significantly higher if the ileum rather than only the colon was affected. Age and sex had no influence. Patients with a haemoglobin content below 12 g/dl (women) or below 13.5 g/dl (men), or an albumin concentration under 4.0 g/dl, or a blood sedimentation rate over 30 mm in the first hour had a probability of operation after ten years nearly three times higher than those without one of these findings. A prognosis about the likely future course of the disease can be made from its localization and the biochemical values. Thus patients with an early ileocolitis and unfavourable biochemical findings apparently constitute a subgroup in which the disease takes a primarily aggressive course.

Age Factors↗
PubMed1982

The origin of dolichol in the liver of the rat. Determination of the dietary contribution.

Commercial laboratory rat chow was found to contain 8.3 micrograms/g of dolichol and 2.1 micrograms/g of polyprenol; each was 14-18 isoprenes in length. The chain length and relative concentration of rat fecal dolichol and polyprenol were approximately the same as in chow, indicating that there was no preferential absorption of a particular chain length or a particular class of prenols. To quantitate the absorption of these compounds, rats were intubated with either [3H]dolichol or [3H]polyprenol or, as a control, [3H]cholesterol. After 30 h, the amount of radioactivity accumulated in the liver of the [3H]cholesterol-fed rat averaged 6% of the total administered. In contrast, the amount of radioactivity present in the livers of the [3H]dolichol- or [3H]polyprenol-fed rats was 0.05% of the total. From these data the maximum hepatic accumulation of the dietary prenols was calculated to be 0.06 micrograms/30 h. When compared with the values obtained for hepatic de novo synthesis (Adair, W. L., Jr., and Keller, R. K. (1982) J. Biol. Chem. 257, 8990-8996), we conclude that the contributions of the diet to the liver dolichol pool is negligible.

Animals↗
PubMedDate not supplied

Superparamagnetic iron oxide: detection of focal liver lesions at high-field-strength MR imaging.

AMI-25 was evaluated at 1.5 T as a superparamagnetic iron oxide contrast agent for the liver. Sixteen patients with up to five suspected focal liver lesions were examined with T1-, proton-density-, and T2-weighted spin-echo sequences before and after intravenous administration of AMI-25 (15 mumol/kg iron). The contrast-to-noise ratio (C/N) increased from 1.8 to 3.5 on 600/15 (TR msec/TE msec) images and from 1.7 to 7.9 on 2,500/15 images after AMI-25 administration (P < .01). C/N did not change significantly on 2,500/90 images. Two blinded readers counted the number of lesions visible on unenhanced and contrast-enhanced images, with the 32 sets of images of the 16 patients presented in random order. Both readers identified more lesions on AMI-25-enhanced images, but the difference was not statistically significant (P > .05). Two patients reported minor side effects (flushing, sensation of heat, lower back pain). On the basis of the results obtained in a limited number of patients, the authors conclude that at 1.5 T, AMI-25 does not significantly improve the detection of focal liver lesions on conventional spin-echo images.

Contrast Media↗