Designated blood donations.
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Blood Banks↗
Biomedical subjects
E K Draper
Publications and source records attributed to E K Draper.
Survival of Kn(a+) McC(a+) red cells in a patient with anti- "Kna/McCa".
The in vivo survival of Kn(a+)McC(a+) red cells in a patient with anti- "Kna/McCa" was studied using 51Cr-labeled incompatible cells. The antibody was IgG4, demonstrable at 37 degrees C in the antiglobulin test, and did not bind complement. Survival of tagged cells was 82.2 percent after 24 hours. The patient was transfused with a total of 29 units of incompatible blood with no evidence of ill effects. The direct antiglobulin test became positive after transfusion and remained positive for 2 1/2 months of observation. The findings suggest that individuals with anti- "Kna/McCa" may be transfused with Kn(a+)McC(a+) red cells.
Blood Group Antigens↗
Transfusion problems in renal allograft recipients. Anti-lymphocyte globulin showing Lutheran system specificity.
Heterologous anti-lymphocyte globulin (ALG) is known to contain panagglutination activity and may cause a positive direct antiglobulin test in a renal allograft recipient. Three patients are reported in whom the passively acquired antibody showed apparent specificity in the Lutheran blood group system. The sera of these patients and eluates from their red cells displayed reactivity consistent with a Lutheran-related antibody. While the neat ALG acted as a panagglutinin, the Lutheran system specificity appeared only following dilution of the ALG. This specificity did not appear to represent a separate, distinguishable antibody in the ALG product. Before considering the utilization of units of the rare Lu(a-b-) phenotype for transfusing a renal allograft patient who has a Lutheran-related antibody, investigation of ALG as a source of that antibody should be conducted.
Adult↗
Pre-transfusion testing problems caused by anti-lymphocyte globulin and their solution.
Anti-lymphocyte globulin (ALG) is an antibody to human lymphocytes used to decrease T-cells in renal transplant patients. We recently encountered serologic problems in testing blood from patients treated with ALG. Thirty-nine patients undergoing acute kidney rejection developed positive direct and indirect antiglobulin tests following the administration of equine ALG. Sera from these patients reacted with all red cells (RBCs) tested using both polyspecific and monospecific anti-IgG anti-human sera. Eluates prepared from the patients' RBCs showed similar reactivity. The ALG panagglutinin did not react by manual hexadimethrine bromide (Polybrene) technique. The ALG panagglutinin could be neutralized by anti-human globulin. In our hands, these techniques were useful in distinguishing ALG panagglutinin from co-existing alloantibodies.
ABO Blood-Group System↗