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Biomedical subjects

E K McGough

Publications and source records attributed to E K McGough.

3 recordsLinked to original sources

Variations in tidal volume with portable transport ventilators.

BACKGROUND: As intra- and interhospital transportation of ventilator-dependent patients has become more commonplace, the number of portable transport ventilators has increased. Transport ventilators should be capable of delivering consistent tidal volume (VT) from breath to breath following changes in lung-thorax compliance and airways resistance. We sought to determine the effect of changes in compliance (C) and resistance (R) on the VT delivered by eight commercially available, time-cycled transport ventilators. METHODS & MATERIALS: Each ventilator (PneuPAC Model 2, Autovent 3000, MAX, Bird Transport Mini-TXP, IC-2A, P7, E100i, and Logic 07a) was connected to a calibrated pneumotachograph and a test lung set for normal adult C (C = 100 mL/cm H2O [1.02 L/kPa]) and R (R = 2 cm H2O.s.L-1 [0.2 kPa.s.L-1]), with VT at 1,000 mL. RESULTS: As C and R were manipulated, VT varied widely. Tidal volume decreased least with the P7 and most with the Bird transport ventilator. CONCLUSION: Decreases in VT with a transport ventilator predispose patients to hypoventilation, hypercapnia, and acidemia. Tidal volume often is not monitored continuously during transport, yet large decreases in VT must not be allowed when pulmonary mechanics are unstable. Internal pressure-limiting valves, venturi flow-generating devices, and compression volume in the breathing circuit are at least three factors that affect VT with transport ventilators.

Equipment Design↗

Pressure support and flow-cycled, assisted mechanical ventilation in acute lung injury.

Pressure support is a ventilatory mode, available with many microprocessor ventilators, which is patient-triggered, pressure-limited, and flow-cycled. This study compared the respiratory and hemodynamic effects of PS used as a stand-alone mode of ventilation with those of conventional patient-triggered, flow-cycled, assisted mechanical ventilation. Instruments for hemodynamic and respiratory measurements were placed in ten spontaneously breathing, anesthetized sheep. In each animal, baseline measurements were made during PS and flow-cycled AMV. Acute lung injury was then instituted by instilling hydrochloric acid in the endotracheal tube, and after 60 minutes, measurements were repeated. No hemodynamic or respiratory variables differed, either before or after ALI, between PS and AMV. This study demonstrates that PS, when used as a stand-alone mode of ventilation, has similar hemodynamic and respiratory effects as flow-cycled AMV.

Animals↗

Unexpected bronchospasm during spinal anesthesia.

Asthma and bronchospastic disease are common in patients presenting for anesthesia. Intraoperative bronchospasm can be a life-threatening problem. One approach to these patients is to use regional anesthesia because it is believed that this will reduce the complication rate. Presented here is a case of bronchospasm occurring during regional anesthesia that was unresponsive to beta agonists. The use of atropine in the treatment of bronchospasm also is discussed.

Anesthesia, Spinal↗