Biomedical subjects

E Knoth

Publications and source records attributed to E Knoth.

18 recordsLinked to original sources

PubMed1997

[The determinants of the quality of life after a type-III open tibial fracture. The results of a multicenter study].

This study investigated to what extent quality of life four years or more after the fracture is determined by initial staging (Gustilo subclassification, time from injury to arrival at hospital), by the therapeutic course (length of hospital stay, number of operations), by complications (amputation, infection) and by demographic factors (gender, age). A total of 197 patients after type III open tibial shaft fractures (type IIIA 70, type IIIB 85, type IIIC 42) from nine centers volunteered to participate in this study. During patients' follow-up appointments (mean duration of follow-up 50 months), therapeutic course, pre-surgical staging and demographic data were recorded by the surgeon. Patients were asked to rate quality of life on the Nottingham Health Profile and on a visual analogue scale. Multiple regression analysis (stepwise) identified two predictors for reducing overall quality of life (F-test: P = 0.007): number of operations (adjusted beta: -0.21) and age (adjusted beta: -0.17). Other factors showed no significant relationship with overall quality of life or with subscales of the Nottingham Health Profile. These findings indicate a dilemma between two therapeutic goals: good functional outcome, which often requires repeated operations, and quality of life, which suffers under prolonged surgical treatment.

Adult↗

PubMed1988

Neutrophil elastase alpha 1-proteinase inhibitor complexes in pleural effusions.

Polymorphonuclear (PMN) granulocyte derived neutrophil elastase (NE) is rapidly antagonized by alpha 1-proteinase inhibitor (alpha 1 PI) in vivo. To determine the clinical value of elastase alpha 1-proteinase inhibitor complexes (E-alpha 1 PI) in pleural effusions, fluid samples of 99 patients were examined. Fifty-six had malignant effusions, 30 had non-malignant exudates (pleural protein above 3 g/dl) mainly of inflammatory origin, and 13 patients had low protein transudates (below 3 g/dl) due to congestive heart failure. Nonmalignant exudates showed significantly higher (P less than 0.001) concentrations of E-alpha 1 PI compared with malignant effusions or low protein transudates (P less than 0.001). Malignant exudates secondary to lung cancer were characterized by higher (P less than 0.001) median pleural E-alpha 1 PI concentrations compared to malignant exudates due to primarily extrathoracic malignancies. Total pleural leukocyte counts and pleural neutrophil counts were performed in 68 effusions. By this means no clear-cut differentiation between malignant and nonmalignant exudates seems possible except for marked empyema. In conclusion, E-alpha 1 PI complexes in pleural fluid may better reflect the stage of inflammation of pleural effusions rather than mere pleural leukocyte counts. Low levels of E-alpha 1 PI complexes (less than 75 ng/ml) in pleural exudates with protein values above 3 g/dl are characteristic of malignant exudates. Determination of E-alpha 1 PI in pleural exudates may serve as a sensitive marker of inflammation and useful adjunct to pleural cytology in aspects of differential diagnosis of pleural effusions.

Blood Proteins↗

PubMed1988

[Hematoporphyrin derivative-induced tumor fluorescence].

Detection of HpD-sensitized tumour was successful by use of HBO 200 mercury lamp, Argon ion laser, as well as for N2-pumped dye laser. After 20 hours period of HpD application the localization of the Ehrlich ascites tumour in mice was identified macroscopically and by spectroscopy. To exclude red emissions of detection sources the use of dye lasers is recommend.

Animals↗

PubMed1988

[Effects of the argon laser on bronchial tumor tissue].

Argon-ion lasers emit blue-green light, transmittable via fiber for endoscopic tumour therapy and coagulation of small vessels. Effective tumour vaporization could be performed in native biopsy specimens using cw-Argon laser with adjusted power and application time. Tissue colour and vascularity influence the laser effect.

Bronchi↗

PubMed1988

[Expanded thoracic use of the laser].

Using conventional lasers authors create diagnostic and therapeutic thoracoscopic procedures for improvement of present spectrum of pulmonary therapy. Transthoracal punction for insertion of laser fibre and integral photoradiation therapy of pleural tumors are described as new therapeutic laser methods.

Carcinoma, Bronchogenic↗

PubMed1987

[Experimental and clinical experiences with bronchologic lasers].

Bronchological application of lasers is based on differences of their biophysical effects, which were confirmed in experimental investigations. There were early reepithelizations and rapid healing after laser tracheotomy and lung resections without signs secondary stenoses by hypergranulation. Argon laser is of limited use in bronchology for HpD-coupled tumor fluorescence diagnostic. Nd-YAG-laser is the "classic" laser for palliative bronchial tumor therapy. Improvements of laser applications (laser thoracoscopy, perthoracic laser punction therapy) are new therapeutic laser methods.

Airway Obstruction↗

PubMed1985

[Differences in the effects of laser radiation on the myocardium and liver induced by a combination of histochemical succinate dehydrogenase demonstration and acridine orange fluorochromy (MS-AO-technic)].

In laser induced wounds of myocardium and liver of rats, 1 reversible zone and 3 irreversible zones of damage can be separated in dependence of time until 24 h by a combined enzyme-histochemical and fluorescence microscopical technique. Besides these zones, another carbonized zone is also detectable. A mainly reversible zone of contraction can be seen for a short time in the myocardium. The results indicate different types of manifestation of laser and ischemic induced tissue necroses.

Acridine Orange↗

PubMed1985

[Electrically activated blood].

By means of direct current electrically activated blood (EAB) is an endogenous thrombogenic substance. One vessel is occluded permanently by an agglutinative thrombus after injecting such blood. So the thrombosis can be simulated in experiment. In face of the endogenous fibrinolysis EAB proved more resistant than spontaneously coagulated blood and also after adding thrombus in vitro. An iodinated X-ray contrast medium (Visotrast 370) prevents the thrombosis of an artery by EAB.

Animals↗

PubMed1983

[Hepatitis syndrome following heart surgery using extracorporeal circulation].

195 patients who underwent heart operations by means of extra-corporal circulation were followed-up for virus hepatitis in a prospective study. 15 cases of hepatitis occurred, 6 developed hepatitis type B, 9 hepatitis non-A-non-B. 41 out of 142 patients examined had no antibodies against cytomegaly virus, in 7 patients a seroconversion took place. Epstein-Barr-virus does not play a clinical role.

Adolescent↗

PubMed1983

[Use of lasers for the excision of calcified heart valves--an experimental study].

Cut effect and clinical employment possibilities of the CO2 Laser were tested in 25 calcified and scarred indurated surgical specimens of human mitral and aortic valves. Sparing incisions even of fine structures as papillary muscles and tendinous fibres are possible without traumatism. Calcification parts were transected analogous to the osteotomy, so that originate accurate incisions in the focus and incinerations and evaporation effects outside of the focus. The conception of an exchangeable grip will be recommended for the clinical employment to the certain exclusion of accessory lesions.

Aortic Valve↗

PubMed1983

[Embolism caused by cardial myxoma].

Myxomas of the heart may present a systemic embolization before heart valve occlusion. A histological examination of peripheral emboli may result in the diagnosis. The tumour should be removed early before the occurrence of irreversible embolic complications. An embolic history could be found in 5 of our 8 cases. Two patients died immediately after complete peripheral arterial obstruction.

Adult↗

PubMed1983

[Aneurysm of the membranous septum of the heart. A diagnostic and therapeutic challenge].

Aneurysms of the membranous portion of the interventricular septum are considered to be rare cardiac lesions. Left ventricular angiography appears to be the only method to establish the specific intravital diagnosis. Rupture, infection, thromboembolism, and obstruction of the right ventricular outflow tract have been documented for complications of this malformation. Early resection should be performed before complications occur. 4 patients underwent successful open heart correction of the aneurysm. In another patient a bundle branch block was present and a pacemaker was implanted.

Adolescent↗

PubMed1982

[Primary benign intramural intracavitary cardiac tumors--clinical, diagnostic and therapeutic aspects].

10 cases of benign primary tumours of the heart (5 myxomas of the left atrium, 2 myxomas of the right atrium, 1 right-ventricular endothelioma of the endocardium, 1 left-ventricular pseudorhabdomyoma, 1 tumour of the interventricular septum) are described. The diagnostically decisive method was in 5 cases the heart catheterization with angiocardiography, furthermore in one case each the roentgenogram of the thorax, the echocardiography, the histology of embolic material, the operation as well as the autopsy. The echocardiography was available for 4 patients; in one case it was diagnostically decisive, delivered important additional informations in 2 patients and failed in one patient. With increasing propagation of the echocardiography, which in the opinion of the authors at least in all cases should be used before a planned invasive cardiological diagnosis, is to be reckoned with an improvement of the diagnosis of tumours of the heart and with an increase of the chances of a causal, namely the timely cardiosurgical therapy.

Adult↗

PubMed1981

[Evaluation of lung function and pulmonary hypertension preceding surgery of acquired heart defects].

We investigated the connection between the pulmonary hypertension and the lung function in the preoperative time of 176 patients undergoing an operation for prosthetic valve replacement in mitral and aortal position and in both of them. Excluding other causes of restriction we found a distinct coherence between vital capacity and residual volume in heart failures of the mitral valve. The findings of patients with aortic valve disease of the heart show the same trend as in the mitral valve, but there are differences of quantity. The changed respiratory mechanics is dependent of the disturbed haemodynamics and depends on the duration of the development of the valvular defect, too.

Adult↗

PubMed1980

Intestinal alkaline phosphatase and the ABO blood group system--a new aspect.

The influence of erythrocytes of different blood groups on the intestinal isoenzyme of alkaline phosphatase (EC 3.1.31.1) was investigated. Binding of the enzyme to erythrocyte membranes was demonstrated by sedimentation experiments, by enzyme electrophoresis, by gel chromatography and immunologically using a modified Coombs technique. We found that red cells of blood group A bind almost all intestinal alkaline phosphatase; erythrocytes of blood group B or O to a much lesser degree. This is in accordance with the fact that intestinal alkaline phosphatase is found more frequently in the serum of individuals of blood group O or B than in serum of persons of blood group A. We conclude that underlying the described blood group dependent differences in synthesis of intestinal alkaline phosphatase lies a mechanism involved in the regulation of the activity of intestinal alkaline phosphatase in human serum.

ABO Blood-Group System↗

PubMed1979

[Acid-base balance].

Explore the source record for details and available documents.

Acid-Base Equilibrium↗

PubMed1979

[Measuring the activity of the placental isoenzyme of alkaline phosphatase: 3 methods compared (author's transl)].

Three methods were compared in human serum for determining the activity of the placental isoenzyme of alkaline phosphatase: 1. Heat inactivation at 65 degrees C for 10 minutes, 2. Differential inactivation with L-p-Bromotetramisole, and 3. an immunological precipation test. A good comparison between the three methods was found (correlation coefficient between 0.973 and 0.982). For long series or screening determinations for "Regan-isoenzyme" the differential inactivation with L-p-Bromotetramisole is preferred because of the short analysis time and the possibility of simple mechanisation.

Alkaline Phosphatase↗

PubMed1977

[Atrial myxomas of the heart; diagnosis, therapy and morphology (author's transl)].

Atrial myxomas imitate several other clinical entities. The intravital diagnosis may still appear as a surprise. Myxomas can present themselves in 2 ways: by obstruction of intracardiac blood flow and by embolization. Early diagnosis should be established by utilizing angiography. Immediate resection under total cardiopulmonary bypass should be performed before catastrophic complications occur.

Adult↗