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Biomedical subjects

E Kokue

Publications and source records attributed to E Kokue.

68 records · Page 4Linked to original sources
PubMed1982

Teratogenic activity of pyrimethamine in Göttingen minipig.

Pyrimethamine (PY) was mixed with mashed feed and given to the Göttingen miniature pig (G-mini) during gestional days 11-35. Major malformations such as cleft palate, club-foot and micrognathia were observed in 11 out of 16 newborns from 3 pregnant sows which received 3.6 mg/kg/day. Two sows of a high-dose group (7.2 mg/kg) showed severe anemia and low appetite during the experiment and did not give birth. No malformation was found in 22 newborns of low-dose groups (0.9 and 1.8 mg/kg). Among 130 offspring which died before weaning out of 505 from 47 farrows in a breeding farm, major teratoses such as cleft palate were found in 8 newborns.

Abnormalities, Drug-Induced↗
PubMed1981

Serial endoscopic observation of swine gastroesophageal ulceration induced by injection of a histamine-oil-beeswax mixture.

The gastroesophageal (GE) area of swine was endoscopically observed before and after injection of a histamine-oil-beeswax mixture (5 mg of histamine/kg of body weight). The swine were anesthetized with halothane, and a rigid endoscope was inserted through a gastric cannula placed in the proximal greater curvature of the stomach. Observation was simple and the procedure lasted less than 10 minutes, without adverse reactions. In 4 swine with normal GE areas, hemorrhage was found at postmedication hour (PMH) 3 and ulcerative changes were seen at PMH 9 to 12. A more rapid pathologic change of the GE area was found in 2 animals with hyper- or parakeratotic changes before medication. Abnormalities were found up to PMH 9 in the GE area of 2 animals in which the stomach cannula was opened to allow the escape of gastric juice.

Animals↗
PubMed1976

The endogenous secretin in chicken: minor physiological role in exocrine pancreatic secretion.

The action of secretin (SN) on the exocrine pancreas in the chicken was studied in comparison with the rat and dog. Hydrochloric acid (0.1 N), pepton (5%) and olive oil were introduced into the small intestine of conscious chickens with chronic pancreatic fistula and caused the volume and protein output to increase slightly in about two-thirds of the chickens tested. The percent increase of the volume output in anesthetized chickens by HCl instillation was only one-tenth of that in the rat. Acid extracts of the intestinal mucosa (80 mg) from chickens when given intravenously to rats caused the volume of secretion from the rat pancreas to increase about twofold, whereas the extracts from the dogs' and rats' intestine increased the volume output 5.9 and 5.5 times respectively. The increase of pancreatic secretion in chickens by intravenous injection of commercial SN was about one-third of that in the rat. The present studies indicate that SN or a SN-like hormone may be present in the chicken, but it plays only a minor physiological role.

Animals↗
PubMed1975

[Action mechanism of sodium polyacrylates against stomach ulcer].

Three sodium polyacrylates (PAS) with different viscosities were examined for antiulcerogenic properties. Rats were fed with sugar containing a PAS for 4 hr and subjected to 12 hr reserpinization or stress by water immersion. Lower incidence of ulceration and larger amount of stomach content after the experiment were found in the PAS administered groups. The higher viscous PAS was more effective in prevention of ulceration and in prolongation of gastric emptying. Intragastric administration of the drugs to pylorus ligated rats reduced forestomach ulceration. However, differences in the antiulcerogenic activity of three drugs were not observed. The effects on the gastric secretion of three PAS (50 mg) were also examined, using pylorus ligated (6 hr) rats. In PAS groups, the free acid in the gastric juice was reduced to some extent. There was, however, no relation between the antiacid effect and viscosity. The drugs inhibited the peptic digestion in vitro, but the difference of viscosity was not related to the antipeptic effect. It is concluded that prolongation of gastric emptying may be a major factor in the antiulcerogenic activity of PAS.

Acrylates↗