Biomedical subjects

E Kollig

Publications and source records attributed to E Kollig.

At least 19 recordsLinked to original sources

PubMed2003

[Traumatic atlanto-axial rotatory fixation with lateral mass fracture of the axis].

Traumatic atlanto-axial rotatory fixation (AARF) is a relatively uncommon injury, especially in association with fractures of the axis. The rotatory dislocation and fixation is normally caused by intercalated facet joints of axis and atlas. A traumatic AARF in a 21 year old female is presented with special emphasis on the diagnostic and therapeutic approaches. This high velocity injury was caused by a traffic accident. The trauma service which was initially involved made the correct diagnosis and tried to reduce the dislocation by skull traction during analgesia and sedation, but without success. For further treatment, the patient was referred to a level one trauma center. After completing the diagnostic imaging with MRI and CT for exact delineation of the fracture site and determination of ligament damage, a halo fixation for skull traction was installed. This second attempt was also unsuccessful. Only a closed reduction under general anesthesia with muscle relaxation led to a neutral alignment and congruent joint contact between C1 and C2. Due to the stable fracture site and the intact ligaments, a conservative treatment with a stable collar splint was performed.

Accidents, Traffic↗

PubMed2003

[Complex fractures of the humeral head: which long-term results can be expected?].

BACKGROUND: Although improved techniques of internal fixation and prosthetic replacement were introduced successfully in the field of operative fracture care, treatment of complex fractures of the proximal humerus also involving the humeral head remains to be a challenge to the trauma surgeon. We therefore investigated clinical and radiological long-term results after humeral head preserving procedures. METHODS: 41 patients with a three or four part fracture of the humeral head were evaluated on average 6.6 years (min. 4.4 y; max. 9.0 y) after the trauma. The evaluation was based on the Constant- and HSS score clinically and on the Neer score radiologically. Nine patients were treated conservatively (group A), 13 patients had primarily an operative treatment (group B) and another 19 were operated upon after failure of conservative means. 24 of the patients were female and 17 male, with an average age of 52 years (min. 14.4 y; max. 71.2 y). According to Neers 's fracture classification of humeral head fractures we saw 14 type IV, 25 times a combination of type IV and V and in another 2 cases a type VI fracture. RESULTS: In group A (conservative) the Constant score showed on average 82.0 points for the injured and 95.3 points for the contralateral shoulder, the HSS score revealed 73.6 points and Neer's x-ray score 5.6 points. Group B (operated) showed also good results on average according to a Constant score of 72.1 points (fractured humerus) compared with 98.1 points of the contralateral shoulder. HSS score was 64.7 points. The radiological results reached 4.0 points. Group C (conservatively failed, secondary operation) achieved 68.2 points for the injured side and 95.8 points for the contralateral side according to Constant and 59.5 points according to HSS score. The x-ray evaluation showed 5.3 points. Fracture type did not influence the outcome in any of the groups. There was no humeral head necrosis in group A, one in group B (2.4 %) and four in group C (9.8 %). CONCLUSION: These data show that regarding to clinical and radiological long-term results also complex fractures of the humeral head should be treated by head preserving procedures.

Adolescent↗

PubMed2003

[Primary hemiarthroplasty after complex fracture of the humeral head--functional late results].

UNLABELLED: Treatment of complex fractures of the humeral head remains an obviously unsolved problem. Under consideration of the problems of head preserving methods, the development of the last years tended towards the hemiprosthetic replacement. As the discussion about the methods and implants continues to be controversial, long-term results of Neer-II-replacement of humeral head in own trauma cases are presented here. PATIENTS AND METHODS: 46 patients were investigated, in whom a cemented Neer II hemiprosthesis was implanted between 1983 and 1996 due to complex fracture patterns. Median age was 60.2 years, 74 % of patients were female. 59 % had a luxation fracture type Neer VI, 22 % presented a concomitant nerval lesion. Follow up was performed 5 years on average after the operation. 38 patients were investigated clinically according the score of Constant and Murley, 36 had a x- ray control. Additionally an individual questionnaire was completed by 46 patients. RESULTS: Average Constant-score was 66.2 points, whereas in 76.3 % a satisfactory or better result was achieved. In 23.9 % the outcome was poor. In one patient (2.2 %) explantation of the hemiprosthesis and shoulder fusion due to pain was necessary. Conditions for a good result were a patient aged 50 years and younger (75.9 pts. versus 64.2 pts.), an early hemiprosthetic replacement within 4 weeks after the trauma (71.7 pts. versus 55.3 pts.) and a patient without an earlier operation and nerval lesion (76.8 pts. versus 53.9 pts.). No correlation was found between the date of the follow-up and the interval of time since the operation. CONCLUSION: After complex fractures of the humeral head satisfactory long-term results can be obtained by the cemented Neer II hemiprosthesis. Thus, implants of the newer generation can not yet whitness their superiority under consideration of functional aspects. Refixation and reintegration of both the tubercula after trauma still seems to be an unsolved problem and requires further development.

Adult↗

PubMed2002

[Outcome quality in trauma surgery].

Trauma surgery and orthopedic trauma surgery have been accompanied not only by internal quality assessment, but also by external quality assessment procedures right from the beginning. The reasons for these mechanisms were based on legal regulations of treatment of work-related accidents. In 1958, the Arbeitsgemeinschaft für Osteosynthese (Working Group on Osteosynthesis, AO group) was founded. The results of the AO's scientific activities built the basis of osteosyntheses. In 1988, legal regulations changed again in Germany. Since this reform of some important facets of public health care, each hospital or institution is committed to perform external and internal quality assessment. In addition, the introduction of a payment system based on diagnosis-related groups makes it necessary to install basic quality management systems within the next few years. This paper presents some well-established procedures, especially the diagnosis-related study in the whole district of Westphalia-Lippe. The aim of the study was a quality assessment of the treatment of intracapsular fractures of the collum of the femur. Problems in data analysis and interpretation are shown. Because of some grave problems, certain changes in the study design seem to be warranted. Despite these facts, however, we are convinced that we not only need this kind of quality assessment, but that we should try to expand these studies based on the experiences we gained.

Accidents, Occupational↗

PubMed2002

[Septic arthritis of the shoulder following intra-articular injection therapy. Lethal course due to delayed initiation of therapy].

Detection of a bacterial arthritis of the shoulder represents an absolute indication for intervention. Irrespective of the cause of the infection, the most decisive prognostic factors are early diagnosis and therapy. We report on two patients who suffered from generalized sepsis and resulting death after delayed treatment of iatrogenic joint infections of the shoulder caused by intra-articular injection therapy. Both patients suffering from septic shock syndrome had been transferred to our hospital for surgical and intensive care treatment. They died in spite of maximal intensive care and aggressive surgical treatment. On the basis of the cases presented, it can be concluded that an acute infection of the shoulder joint must be excluded early when painfully limited range of motion in combination with clinical and laboratory signs of inflammation become apparent. Successful therapy of joint infection also requires early surgical treatment, including resection of infected tissue. If surgical joint revision is not performed or is performed too late, there is the risk of irreversible damage to the afflicted joint, even septic spread endangering the patient's life.

Aged↗

PubMed2001

[The diagnostic concept of acute infection of the shoulder joint].

INTRODUCTION: It is generally accepted that septic conditions of the shoulder often lead to an earnest situation with joint damage. Because of the low incidence of shoulder infections there are only a few cases reported in the literature. Therefore, unlike joint infections of the knee no diagnostic and therapeutic standard procedure is documented for the shoulder. MATERIALS AND METHODS: In a retrospective study the results of 15 patients with a surgical revision at the BG-Clinic-Bergmannsheil-Bochum between 1 January 1989 and 31 August 1999 after an infection of the shoulder joint were analyzed. We registered the following parameters: etiology, intervall until the first clinical symptoms, clinical signs, diagnostic procedure, intraoperative site (Gächter classification), and operative treatment. The diagnostic procedure followed an algorithm, including CRP-determination, ultrasound of the shoulder, ultrasound-guided aspiration and a Gram stain. If the result was positive, surgical joint revision followed. The infection stage was classified intraoperatively according to the criteria of the Gächter classification. Eight patients were reexamined after an average follow-up of 4.8 years. RESULTS: Fourteen infections followed injection. All patients demonstrated increasing CRP levels and a painful limited range of motion. In all Gram stains we detected bacterial organisms. The diagnosis of an acute infection according to the criteria of this diagnostic algorithm was verified intraoperatively in all 15 joints. Two patients with delayed admission died postoperatively due to septic multiorgan failure despite maximal treatment under intensive care conditions. CONCLUSION: If there are suspicious clinical symptoms after a typical anamnesis, we recommend an immediate diagnostic algorithm, including CRP determination, ultrasound of the shoulder, ultrasound-guided joint puncture and a Gram stain. If there is acute joint infection, time-consuming diagnostic procedures must be avoided because of the risk of secondary reduced joint mobility or life-threatening complications.

Acute Disease↗

PubMed2001

[Internal fixation of subcapsular fractures of the femoral neck].

Beside of modern surgical and implant techniques and basic pathophysiological knowledge, internal fixation of subcapsular fractures of the neck of the femur is still known to be connected with a high rate of complications. Implant failure, the typical early complication arising within the first 3 months, non-union, avascular necrosis of the femoral head and late segmental collapse are the typical complications. The type of fracture, timing of operation (emergency operation), quality of reduction and implant positioning have all been shown to predict outcome significantly. However, it is also suggested that further therapeutical interventions like intra-articular pressure decrease by evacuation of hematoma, the kind and technique of reduction, special surgical techniques and postoperative treatment can influence outcome, as well as patient-associated factors like age, degree of osteoporosis, neurological disease, and alcoholism. The superiority of one of the 100 different existing implants have not been proved either by clinical or by biomechanical trials. However, besides screw osteosynthesis, the sliding screw plate and less often sliding nail plate implants are commonly used. Because of the very different biomechanical principles it is of great importance to adhere to the special operative techniques to avoid intraoperative complications that might cause treatment failure. To reduce the frequency of these almost always fatal and in special circumstances lethal complications, we need some more detailed information from good clinical trials and sufficient external quality assurance.

Femoral Neck Fractures↗

PubMed2001

Midshaft fractures of the clavicle with a shortening of more than 2 cm predispose to nonunion.

Up to 15% of all fractures involve the clavicle. Nonunion of the clavicle is a rare complication after conservative treatment. It mainly presents as pain at the fracture site and a limited range of motion of the shoulder. The purpose of this study is to define a certain type of fracture of the clavicle that is predisposed to malunion and therefore should be treated surgically after failure of conservative treatment. Thirty-nine patients with delayed or malunion of the clavicle were analyzed. There were 13 women and 26 men. The average age of the male patients was 36.4 years (range 20-59 years) and of the female patients, 43.6 years (range 18-55 years). The mean follow-up period was 2.3 years (range 6 months to 4.2 years). All of them were treated surgically. There were 33 Allman I fractures and 6 Allman II fractures. Of the Allman I fractures, 30 (91%) were shortened by at least 2 cm. Allman I fractures were treated using a reconstruction plate or a dynamic compression plate in combination with bone grafting. The time of operation after fracture ranged from 6 weeks to 8.5 years (average 9.8 months). Pain at the fracture site was the leading symptom in all patients. At 6 months after the operation, 38 patients were free of pain with an unlimited range of motion of the shoulder. One patient (2.6%) complained of a slight weakness on the operated site. One fracture failed to unite (2.6%) and had to be replated. There were no refractures, infections, vessel or nerve lesions. To conclude, in Allman I fractures with a shortening of more than 2 cm, we recommend operative treatment in symptomatic patients if there are no signs of callus formation after 6 weeks.

Adolescent↗

PubMed2001

How risky is early intramedullary nailing of femoral fractures in polytraumatized patients?

There is controversy over both the time of intervention and the technique of surgical stabilisation of femoral fractures in polytraumatized patients. Retrospective analysis of data on 55 such patients revealed that stabilisation within the first 24 h using locked, unreamed nails had no negative impact on the rate of pulmonary complications. The frequency of complications was assessed by comparing immediate intramedullary (IM) osteosynthesis with extramedullary stabilisation in patients with or without concomitant blunt thoracic trauma. Due to the small study population and discrepancies the size of subgroups, no definite statistical conclusions were possible. However, our results suggest that the frequency of complications is determined by the overall severity of injury rather than by the type of acute surgical treatment.

Adolescent↗

PubMed2001

[Long-term results after resection arthroplasty according to Girdlestone for treatment of persisting infections of the hip joint].

INTRODUCTION: Persisting infections of the hip joint are regarded as one of the most feared complications following total hip arthroplasty or failed osteosynthetic treatment of fractures of the proximal femoral part. In these cases resection arthroplasty according to Girdlestone often is the ultimate treatment. METHODS: Twenty-seven patients (11 men and 16 women) who had undergone resection arthroplasty according to Girdlestone could be included in this study. In all cases Girdlestone operations had been performed because of persisting infections of the hip joint. The mean follow-up was 7.1 years. RESULTS: In 22 out of 27 cases (81.5%) eradication of the infection was finally achieved. At the time of re-evaluation 6 patients had no pain, 12 sometimes suffered from moderate pain, 7 from pain during physical activities and 2 patients experienced pain even at rest. At the time of follow-up, 11 patients used a cane, 14 patients needed two canes or crutches and in 2 cases a wheelchair was necessary. The mean shortening of the leg was 5.2 cm (range 3-15 cm). Clinical evaluation using the score according to Merle d'Aubigné and Postel to assess the functional results showed a mean of 6.7 points (range 2-10 points). Of our patients, 59.3 % were satisfied with the functional results obtained. CONCLUSION: In the long run the Girdlestone procedure still seems to be a reasonable salvage operation for persisting deep infections following hip surgery.

Activities of Daily Living↗

PubMed2000

The potential pattern of circulating lymphocytes TH1/TH2 is not altered after multiple injuries.

HYPOTHESIS: A shift in the balance of helper T cells type 1 (T(H)1) toward type 2 (T(H)2) has been suggested as a possible mechanism for impaired immune responses after severe trauma. We suggest that major injuries (polytrauma) induce an alteration in the pattern of T(H)1/T(H)2 cells. DESIGN, SETTING, AND PATIENTS: A prospective study of 35 polytraumatized patients (Injury Severity Score >16) admitted to a trauma intensive care unit at a level I trauma center (university hospital). INTERVENTIONS: Blood samples were collected from patients at various times during their stay in the intensive care unit and from age- and sex-matched healthy individuals. MAIN OUTCOME MEASURES: Serial determinations (n = 81) of intracellular interleukin (IL)-2 (T(H)1 cells) and IL-4 (T(H)2 cells) in stimulated CD3(+) T cells from patients with polytrauma twice a week during their stay in the intensive care unit accompanied by determination of the cell activation marker CD69 using 3-color flow cytometry. In parallel, the release of IL-2 and IL-4 from stimulated peripheral blood mononuclear cells and systemic plasma IL-4 levels were analyzed by conventional enzyme-linked immunosorbant assay. Healthy donors (n = 53) served as the control group. Data were related to outcome, Injury Severity Scores, and time after trauma. RESULTS: Expression of the cell activation marker CD69 was similar in stimulated lymphocytes from patients and healthy donors. There were no significant posttraumatic alterations in numbers of CD3(+) cells stained for intracellular IL-2 or IL-4, except for a minor decrease in IL-2(+) cells during the first week after trauma. Subgroups with high (>24) and lower (<25) Injury Severity Scores or survivors and nonsurvivors revealed no differences in intracellular cytokine staining. In contrast, patients revealed a highly significant decrease in the number of CD3(+) T cells. Mean systemic IL-4 levels did not differ in patients compared with healthy donors. Release of IL-2 and IL-4 from peripheral blood mononuclear cell fractions stimulated with phorbolmyristateacetate and ionomycin was significantly increased in patients with trauma but not from those stimulated with toxic shock syndrome toxin-1. CONCLUSIONS: Patients with multiple injuries have no significant alteration in the ratio of circulating T(H)1/T(H)2 cells. Thus, our results suggest pathomechanisms in posttraumatic T-cell suppression apart from alterations in the T(H)1/T(H)2 pattern.

Antigens, CD↗

PubMed2000

[Does liberation of interleukin-12 correlate with the clinical course of polytraumatized patients?].

INTRODUCTION: Interleukin-12-p70 (IL-12-p70) is a potent immunoregulatory cytokine composed of a heavy chain (p40) and a light chain (p35). Contradicting results have been reported with regard to leukocyte release and systemic concentration of IL-12 after polytrauma. METHODS: We daily analyzed systemic concentrations of IL-12 in polytrauma patients (n = 37, mean ISS 33.9) in comparison to healthy donor values during intensive care course by ELISA. Patients were divided according to their mean IL-12 levels into those with elevated IL-12 (group 1, n = 7), those with decreased IL-12 (group 2, n = 4) and those with IL-12 in the normal range (group 3, n = 26). RESULTS: Patients in group 1 revealed elevated levels of IL-12 up to p70 > 1000 pg/ml and p40 > 2500 pg/ml. The common clinical feature of group 1 was a thorax trauma in combination with pneumonia (85% survivors). Patients with single thorax trauma or pneumonia without thorax trauma (group 3) showed normal IL-12 values. Patients with decreased IL-12 levels revealed also a thorax trauma and pneumonia but all patients succumbed. The groups significantly differ in their stay in the intensive care unit, in TISS, in MODS score and in respiratory ratio, but not in ISS, mean CRP values and leukocyte counts. Correlation analysis revealed no significant relation between systemically altered IL-12 values and clinical parameters, with the exception of a negative correlation of p70 and ISS (r = -0.785) or MODS score (r = -0.314) in group 1. CONCLUSIONS: After major injuries there is no overall suppression of IL-12 formation. Patients with normal or elevated IL-12 levels belong mainly to the survivors, whereas patients with decreased IL-12 levels are at high risk of succumbing to multi-organ failure.

Adolescent↗

PubMed2000

[Fatal soft tissue infections after arthroscopy of the knee joint. A diagnostic or therapeutic problem?].

After detection of a bacterial infection of the joint, an absolute indication for intervention is given. Systemic antibiotic drug therapy is indicated and drainage of the joint has to be performed immediately. The following therapeutic algorithm regimen is a proven remedy in treating pyoarthrosis of the knee joint: During the initial period, the infection can be controlled by arthroscopic irrigation and systemic antibiotic therapy. Depending on the progredient findings or if the symptoms persist, curing the joint by open synovectomy is the next step of treatment. If open joint revision including synovectomy is not performed or is performed too late, there will be a threat of irreversible damage of the afflicted joint up to septic spread endangering the patient's life. We report on two patients suffering from generalized sepsis resulting in death after delayed therapy for knee joint infection. Regarding the presented cases, it can be concluded that indication to early surgical joint debridement including open synovectomy of the knee is still rarely seen after development of pyoarthritis.

Algorithms↗

PubMed2000

[Fracture management in the aged].

Fracture care in a geriatric population should lead to a mobilisation with full weight bearing as soon as possible after the accident. Osteoporosis and associated preexisting disease influences the kind of fracture care as well as the social situation. A retrospective analysis of 888 consecutive patients from 1994 to 1998 showed that the fracture risk for a second independent bony lesion was 5.2% in this population with a mean age of 83.4 years (75 y-97.2 y). 946 fractures were treated operatively with a overall reoperation rate of 10%. 3.1% were soft tissue revisions due to infection, 2.0% were because of implant failure in connection with a deep infection and 5.2% of the reoperation were indicated because of implant failure alone. Distribution of complications showed the advantage of closed, indirect reduction and intramedullary devices and primary hemiarthroplasty in femoral and humeral head fractures.

Aged↗

PubMed2000

Ultrasound and bronchoscopic controlled percutaneous tracheostomy on trauma ICU.

Tracheostomy is a common surgical procedure performed in long-term ventilated patients in intensive care. Since the role of percutaneous dilatational tracheostomy (PDT) on Intensive Care Unit (ICU) has become steadily more important in the last few years, a prospective study was started to evaluate the economic efficiency and to show the minimization of the complication rate of this procedure. In 72 patients we performed PDT as a bedside procedure. Initially the thyroid gland and the subcutaneous vessels were studied by ultrasound in every patient. The puncture of the trachea, the dilatational procedure and the insertion of the tracheal cannula were executed under bronchoscopic monitoring. Finally, a bronchoscopic control view followed via the new cannula to detect intratracheal complications. Mechanical ventilation was maintained during the procedure and controlled by continuous pulse oximetry. According to prior ultrasound findings the place to puncture the trachea was changed in 24% of the patients, in one case tracheostomy was performed as an open conventional procedure. The following complications could be observed: one case involving perforation of a cartilaginous ring, one case with venous bleeding of a small subcutaneous vein and two cases with punctures of the bronchoscope. There were no cases of miscannulation, penetration of the posterior tracheal wall or major bleeding requiring intervention or conversion. The followup study revealed that there was no sign of further complications in any patient. In addition, cost analysis demonstrated that there was a significant economical advantage of PDT in comparison with open standard tracheostomy. Standardized ultrasonographically and bronchoscopically controlled PDT turns out to be a safe, simple and cost effective bedside procedure on ICU. Because of ultrasound examination performed before the procedure, and bronchoscopic surveillance during the procedure, safety of this procedure can be enhanced, thus minimizing the rate of complications.

Adult↗

PubMed2000

[Post-traumatic intrahepatic arterioportal fistula].

Traumatic arterioportal fistulas (APF) are very rare. The most common reasons are liver biopsy and liver injuries. They are also caused by liver tumours and vessel anomalies. This is a case-report of a patient who developed an APF after blunt abdominal trauma. The fistula bearing part of the liver was resected in two sessions. In cases of large APFs with a flow from multiple collaterals the therapy of choice is the embolization. If not possible a selective excision of the fistulous sac or the resection of the fistula containing liver segment are recommended.

Abdominal Injuries↗

PubMed1998

Major injury induces increased production of interleukin-10 in human granulocyte fractions.

Patients with severe trauma or polytrauma frequently acquire alterations in immune functions which are correlated to dysbalanced cytokine synthesis. In these settings the role of polymorphonuclear neutrophil granulocytes (PMN) as cytokine-producing cells is less well characterized. The immunosuppressive role of interleukin (IL)-10 is well known, and increased systemic IL-10 levels are related to the severity of injury and to posttraumatic complications. We determined concentrations of IL-10 in culture supernatants of 30 individual PMN fractions isolated from 18 severely traumatized patients (15 polytraumata, Injury Severity Score: 18-41, 3 severely burned patients) admitted to intensive care units. IL-10 was analyzed by ELISA (R&D Systems, Wiesbaden, Germany). PMN were isolated from EDTA-anticoagulated peripheral blood employing a one-step procedure based on a discontinuous double Ficoll gradient. The cells [1 x 10(6)/ml RPMI 1640 supplemented with 10% fetal calf serum and 25 mM N-(2-hydroxyethyl)-piperazine-N'-(2-ethanesulfonic acid] were stimulated with 0.05% heat-killed Staphylococcus aureus (Pansorbin, Calbiochem-Novabiochem, Bad Soden, Germany) for 24 h using cell culture conditions. Our results show that PMN fractions of traumatized patients produce significantly (P<0.008) higher amounts of IL-10 (354+/-95 pg/ml, n = 30) than normal healthy donor cells (125+/-95 pg/ml, n = 7). IL-10 release from PMN fractions exceeded the release from isolated patients' peripheral blood mononuclear cells induced by similar stimulation or by stimulation with toxic shock syndrome toxin-1 (10 ng) and concanavalin A (2 microg). Our results provide evidence that PMN fractions play an active role in the development of posttraumatic immunosuppression by autocrine or paracrine mechanisms, for example, by suppressing one's own antimicrobial activities or determining the development of T-cell responses via their ability to release IL-10.

Adolescent↗

PubMed1997

Mitoxantrone-induced DNA strand breaks in cell-cultures of malignant human astrocytoma and glioblastoma tumors.

In this study mitoxantrone (Mtx) induced DNA strand breaks were measured with the alkaline elution technique in short term cell cultures derived from human gliomas. Glioblastomas or astrocytomas from 5 patients who underwent intracranial surgery were cultured and incubated i h with different concentrations of Mtx (0, 0.01, 0.1 and 1.0 microgram/ml). The alkaline elution method was modified to measure DNA lesions in human gliomas. Mtx induced DNA strand breaks in a dose dependent manner in all cell cultures tested. There was a linear increase of DNA strand break frequency induced by Mtx between 0.01-1.0 microgram/ml. concerning these in vitro data, Mtx might be potentially useful for the treatment of patients with malignant brain tumors.

Aged↗