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Biomedical subjects

E Korn

Publications and source records attributed to E Korn.

9 recordsLinked to original sources
PubMed1995

Secretion of a large molecular-weight form of insulin-like growth factor by a primary renal tumor.

A 5-year-old boy with an abdominal mass was found to have a primary renal tumor of poorly identifiable histology. Prior to resection of the tumor, the patient exhibited several episodes of biochemical hypoglycemia. The hypoglycemia did not recur after operation. Analysis of tumor tissue and of pre- and post-operative sera by column chromatography showed elevated insulin-like growth factor II (IGF-II) levels in the tumor; an abnormal large-molecular weight precursor form of IGF-II (pro-IGF-II) comprised 53% of total IGF-II in the tumor and 42% in preoperative serum. No pro-IGF-II was found in the serum 6 weeks post-operatively. Abnormal IGF-II secreted by the tumor may have mediated the hypoglycemia seen prior to tumor resection. This pediatric renal tumor is the first to our knowledge for which an association of non-islet cell tumor-related hypoglycemia and elevated tumor IGF-II content has been described.

Carcinoma, Renal Cell↗
PubMed1991

Laser-assisted tarsoconjunctival flap harvesting for lower eyelid defect reconstruction.

Tarsoconjunctival flap procedures are reliable and versatile procedures for reconstruction of large lower lid defects. We present a new carbon dioxide laser-assisted flap-harvesting technique. This technique combines precise and accurate incisions with simultaneous complete hemostasis. We have done carbon dioxide laser-assisted flap harvesting for large and total lower lid defects. The hemostatic evaporative cutting of the carbon dioxide laser decreases time, swelling, and bleeding in obtaining tarsoconjunctival grafts and flaps.

Aged↗
PubMed1990

Oculoplastic update.

Lacrimal tearing problems can be handled using a conservative approach by massage, antibiotic eye drops, nasal saline drops, and good hygienic care of the periorbital region. Cases in which preseptal inflammatory changes or marked exudated debris occur require early surgical intervention. Benign eyelid lesions can be identified in the majority of cases by clinical appearance. Many can be easily excised and left to heal by secondary granulation. Newer laser approaches can decrease pain, swelling and postoperative healing time.

Child↗
PubMed1990

Tarsorrhaphy: a laser-assisted approach.

Exposure keratopathy can be vision threatening. There are many techniques for excising lid-margin tissue. We used the carbon dioxide laser to assist in rapid removal of the superficial lid-margin tissue. The resulting excellent hemostatic qualities decreased the time, supplies, and ancillary help needed to do the tarsorrhaphy. Postoperative results were comparable to conventional techniques.

Adult↗
PubMed1985

Complete nucleotide sequence of the lipase gene from Staphylococcus hyicus cloned in Staphylococcus carnosus.

The lipase gene from Staphylococcus hyicus subsp. hyicus was cloned in Staphylococcus carnosus and Escherichia coli. In both host organisms the lipase gene is expressed and the enzyme is released to the medium. The cloned DNA insert is 2.5 kb in length and DNA sequencing has revealed the location of the gene, the ribosomal binding site and the presence of a typical signal sequence. The open reading frame comprises 1923 nucleotides and gives a preprotein of 641 amino acids with a predicted Mr of 71.382. At the 3' end of the structural gene there are three consecutive stop codons and there is also a transcriptional termination signal.

Amino Acid Sequence↗
PubMed1981

Altered cellular immune functions in patients with Down's syndrome.

Cell-associated immunocompetence was evaluated in 42 patients with Down's syndrome (DS) and compared with that of institutionalized patient control and normal control groups. B lymphocytes, as both percent of total lymphoid cells and absolute number, were markedly reduced in patients with DS. T-lymphocyte proliferative response to phytohemagglutinin mitogen also was significantly decreased. This altered response of the lymphocyte population was evident in both the presence and absence of accessory helper monocytes. Increased Fc receptor (FcR) cell activity, as measured by antibody-dependent cellular cytotoxicity was seen in both the patients with DS and the control patients. This probably resulted from common environmental factors such as exposure to infectious factors such as exposure to infectious agents. No change was found in the WBC counts, percentages of lymphocytes and monocytes, percentages of t cells and FcR cells, or in the natural killer cell activity.

Adult↗