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Biomedical subjects

E Kostiainen

Publications and source records attributed to E Kostiainen.

29 records · Page 2Linked to original sources
PubMed1981

Serum lipids and high-density-lipoprotein cholesterol in women on long-term sustained low-dose IUD treatment with levonorgestrel.

Serum concentrations of high density lipoprotein cholesterol, total cholesterol, and triglycerides were measured in 31 women using levonorgestrel-releasing intrauterine devices and in 30 matched controls. There was no statistically significant difference in the mean values of all three lipid parameters between the levonorgestrel-treated subjects and the control subjects. The mean value for serum triglycerides was 0.79 +/- 0.33 mmol/l in the study group and 0.74 +/- 0.23 mmol/l in the control group. The mean cholesterol values were 5.19 +/- 0.91 mmol/l and 5.39 +/- 0.71 mmol/l in the study group and control group, respectively. The mean serum concentration of high density lipoprotein cholesterol was 1.61 +/- 0.37 mmol/l in the study group and 1.77 +/- 0.38 mmol/l in the control group.

Adult↗
PubMed1978

Toxicity studies with human leukocyte interferon in newborn rabbits.

Daily subcutaneous injections of 5 to 10 million units of partially purified human leukocyte interferon were given to newborn rabbits for 2 weeks or 1 month. The control groups received mock interferon, saline or nothing. The interferon treatment had no overt effect on the development of the animals during the period of treatment. The rabbits treated with interferon had leukocytosis, splenomegaly and prolonged postnatal extramedullary hematopoiesis in the liver and spleen. Certain immune responses were also demonstrated in the rabbits treated with interferon and mock interferon preparations. Platelet counts and the serum-ASAT, -ALAT, -LD and alkaline phosphatase values were normal.

Alanine Transaminase↗
PubMed1975

Blood lipid changes in musculoskeletal trauma of the rabbit.

After multiple long bone fractures, signs of excessive fat transport were observed in rabbits. Staining of albumen in the lipoprotein electrophoresis suggests an increased free fatty acid mobilisation. During the five day experimental period the beta lipoproteins increased while the alpha1 lipoproteins decreased. On the second post-traumatic day, the proportion of pre- beta lipoproteins increased simultaneously with a four-fold increase in plasma triglycerides. Some increase in cholesterol was also observed. An augmented de novo synthesis of fat is proposed as an explanation for part of the increased post-traumatic lipid transport. The changes were compared with a simultaneous occurrence of fat in the lung and kidney.

Animals↗
PubMedDate not supplied

Effect of interferon on plasma lipoproteins and on the activity of postheparin plasma lipases.

The effect of interferon administration on the concentration of plasma lipoproteins and on the activity of postheparin plasma lipoprotein lipase and hepatic lipase was studied in six healthy men. Daily injection of human leukocyte interferon for 1 week lowered the plasma level of total cholesterol, very low density lipoprotein + low density lipoprotein cholesterol, high density lipoprotein cholesterol, and apolipoprotein A-1 in all subjects. Simultaneously, the activity of postheparin plasma hepatic lipase and lipoprotein lipase decreased by 20% to 50%. These observations may be of importance in the interpretation of lipoprotein changes seen in acute and chronic infections and should be borne in mind when prolonged treatment with interferon is considered.

Adult↗
PubMedDate not supplied

Effect of a diet low in saturated fatty acids on plasma lipids, lipoproteins, and HDL subfractions.

The effect on serum high density lipoprotein subfractions of a low fat diet with a high ratio of polyunsaturated-to-saturated fatty acids was studied in 38 middle-aged volunteers (19 men and 19 women) in North Karelia, Finland. The mean serum HDL2 cholesterol decreased from 32 +/- 2 mg/dl (mean +/- SE) to 28 +/- 2 mg/dl (p less than 0.001) during the experimental diet and returned to 33 +/- 2 mg/dl (p less than 0.001) after a return to the original diet. No changes were observed in the concentration of HDL3 cholesterol. A highly significant decrease was observed in serum apoprotein A-I concentration, but not in apoprotein A-II concentration during the experimental diet. It is concluded that a low-fat, high-P/S ratio diet lowers LDL and HDL2 cholesterol in healthy volunteers, but does not influence the level of HDL3 subfraction.

Apoproteins↗