PubMed Health⌕ Search

Biomedical subjects

E Kotiloglu

Publications and source records attributed to E Kotiloglu.

8 recordsLinked to original sources
PubMed2001

Her-2/neu gene amplification compared with HER-2/neu protein overexpression on ultrasound guided core-needle biopsy specimens of breast carcinoma.

Genomic amplification and oncoprotein overexpression of Her-2/neu was studied on ultrasound core needle biopsy specimens of the infiltrative ductal carcinomas of the breast. We performed two colour fluorescence in situ hybridization (FISH) for Her-2/neu and chromosome 17 and compared the FISH results with the immunohistochemical overexpression of Her-2/neu protein by 2 antibodies (DAKO HercepTest and the BioGenex monoclonal antibody AM 134-5M). Furthermore, following radical mastectomy with axillary dissection, Her-2/neu status of the patients were compared with the well known histopathological prognostic factors such as histologic grade, tumor stage, lympho/ vascular invasion, surgical margin status and Paget s disease. Amplification was demonstrated 27% of the cases. Her-2/neu protein overexpression was detected in 47% and 80% of the cases with CB11 and HercepTest respectively. We revealed statistically significant association between the tumor, oncoprotein expression and oncogene amplification (p<0.05). The results of our study showed that combination of IHC and FISH methods enhances the evaluation of tumor genetics at both gene and protein level for the analysis of Her-2/neu in breast carcinoma.

Adult↗
PubMed2001

Primary cardiac angiosarcoma.

Primary malignant cardiac tumors are extremely rare neoplasms. About three-quarters of all cardiac tumors are histologically benign. A 24-year-old man presented to the hospital with dyspnea and chest pain. A solid, dense, nonhomogeneous and rough-surfaced mass (89 x 90 x 36 mm) with protrusion into the right heart cavities was observed on transthoracic echocardiography. The findings were confirmed by transesophageal echocardiography and magnetic resonance imaging. The histopathology of the mass confirmed a diagnosis of angiosarcoma. No evidence of an extracardiac origin of the tumor was found by radiological body imaging. The patient died 2 months after presentation to the hospital.

Adult↗
PubMed2001

Blue rubber bleb nevus syndrome.

Blue rubber bleb nevus syndrome is a rare disorder characterized by distinctive cutaneous and gastrointestinal venous malformations that usually cause massive or occult gastrointestinal hemorrhage and iron deficiency anemia secondary to the bleeding episodes. It is even a rare cause of gastrointestinal hemorrhage during childhood. We describe a 6-year-old boy who had multiple venous malformations all over his body. He also suffered from several episodes of melena, chronic anemia, and growth retardation. The endoscopic examination of the gastrointestinal tract revealed multiple bluish-black sessile and polypoid venous malformations in various sizes. It was possible to remove the largest venous malformations causing massive bleeding during colonoscopy.

Child↗
PubMedDate not supplied

Follicular thyroid carcinoma with a predominant insular component in a child: a case report.

Thyroid carcinoma is rare in children and differs from its adult counterpart in many aspects, including that childhood thyroid carcinomas are all well differentiated. Here we present a 14-year-old female from a goitrous area with follicular thyroid carcinoma with a predominant insular component. The child was well without recurrence or metastases after 5 years of follow-up.

Adenocarcinoma, Follicular↗
PubMedDate not supplied

Dystrophinopathy in isolated female patients with muscular dystrophy.

Immunohistochemical examination of dystrophin is suggested as a useful method for diagnosing Duchenne carriers for genetic counseling, in the absence of an index case. This study included 17 females with an age range of 6 to 17 (mean 11.97 +/- 3.81) years and without a family history of Duchenne muscular dystrophy but with varying symptoms of muscle disease, high creatine kinase concentrations, myopathic muscle biopsies, and normal karyotype. Clinical severity was scored according to neurological findings. Muscle ultrasonography, cardiac evaluation, and pathologic examination were done. Dystrophinopathy was detected in six cases (35.3%). All of these cases included 8-33% partially dystrophin-deficient fibers and four of them also had 2-23% deficient fibers. Three cases revealed a mosaic pattern of dystrophin staining. Neither age nor clinical findings correlated with dystrophinopathy; creatine kinase concentrations correlated significantly, however.

Adolescent↗