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Biomedical subjects

E Kunze-Mühl

Publications and source records attributed to E Kunze-Mühl.

At least 19 recordsLinked to original sources
PubMed1981

[Multiple sclerosis and chromosomal aberrations (author's transl)].

Chromosomal investigations were performed after peripheral lymphocytes taken from 25 healthy females and from 35 female patients suffering from various types of multiple sclerosis had been cultured for 48 hours. The incidence of cells with chromosomal breaks in multiple sclerosis patients (2.0%) was significantly higher than in controls (1.1%): Chi2 = 7.26; DF = 1; p less than 0.01. Furthermore, chromosomal rearrangements (dicentric chromosomes, translocation chromosomes, chromatid exchange figures) were observed more frequently in the MS patients than in the controls. Analysis of the interchromosomal distribution of breaks found in the patients revealed a relative surplus in chromosome A2 and D-group chromosomes.

Adolescent↗
PubMed1981

Observations on the effect of X-ray alone and in combination with ultrasound on human chromosomes.

Human peripheral blood was treated with ultrasound either before or after irradiation, and chromosome aberrations in lymphocytes of peripheral blood cultures compared to those resulting from an equivalent dose of irradiation given alone. When peripheral blood is sonicated at a high intensity (3 W/cm2) for 10 min after irradiation, there is an increase in aberration frequency as compared to control samples receiving the equivalent radiation dose alone. However, should the blood be sonicated at the same frequency and for the same time period before radiation there is no significant increase in total chromosome aberrations over the irradiated controls. On the contrary a significant decreases occurs in certain classes of aberration. When sonification with a lower intensity (20 mW/cm2) was used in combination with irradiation the reverse effect was noted. Ultrasound administered for 10 min after radiation caused no significant increase in aberrations. On the contrary increasing the period of sonification to one hour resulted in a lowering of all types of aberration, significant in the case of dicentrics and total chromosome aberrations, when compared to irradiation alone. Reversing the order of treatment again resulted in the opposite effect to that achieved with comparable experiments at high intensities of sonification. Ultrasound before radiation did not produce lower breakage rates. Instead, when the period of sonification was increased to one hour, the number of aberrant cells, fragments, and total aberrations rose significantly over controls. It is suggested that sonification produces chemical changes affecting cellular repair systems, which when combined with ionising radiation, results in an increased or decreased repair effect depending on the dose, duration, and order of treatment.

Chromosome Aberrations↗
PubMed1976

[Cytogenetic investigations in patients receiving an intraarticular injection of gold-198 (author's transl)].

The chromosomes of lymphocyte cultures from the peripheral blood were investigated in 10 patients (rheumatoid arthritis, ankylosing spondylitis, osteoarthrosis of the knee) before and at short-term intervals (1 day, 3 to 4 days, 14 to 18 days) after the injection of gold-198 (5 to 20 mC; usually 8 mC; average particle size 300 A) into the knee-joint. The number of structural chromosomal abberrations increased markedly in 4 of the 10 patients. On the first day after the gold injection the mean aberration rate was significantly higher than the control value (Chi2-5.18; df=1; P less than 0.05). Most of the observed aberrations were chromatid aberrations and this finding is discussed.

Aged↗
PubMed1975

[Chromosomal instability in homo- and heterocygocity for microcephalia vera )author's transl)].

In a family with microcephalia vera, not only the 3 microcephalic probands, but also their healthy mother showed a significantly increased rate of spontaneous structural chromosomal aberrations in cultures of lymphocytes of the peripheral blood. Thus an increased aberration rate in the lymphocytes of asymptomatic family members could serve as a sign of heterocygocity. The qualitative analysis revealed aberrations of the chromatid and chromosomal type; exchanges that are frequently found in Fanconi's and Bloom's syndrome could not be detected. Therefore it can be assumed that the chromosomal instability of microcephalia vera is caused by a specific mechanism.

Adult↗