Biomedical subjects
Publications and source records attributed to E L Bazhenov.
The authors present results of combined treatment of 60 patients with chronic atrophic gastritis with riboxine. A favorable effect was registered on clinical symptoms, acid-forming function, ultrastructure of gastric mucosa. The above positive effects of riboxine make it useful in combined treatment of chronic atrophic gastritis.
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A quantitative characteristics of destructive and reparative processes in the organs of immune system is given on the model of acute peritonitis running under different conditions. During the usual course of inflammation in the abdominal cavity in the first 24 hours a sharp increase of lymphocyte destruction is noted, while proliferative changes decrease. Two days later the cell destruction decreases but proliferative changes increase. While using levamisole the destructive phenomena are not highly marked but proliferative processes persist at a high level during all periods of the experiment. In azathioprine immunosuppression the process of destruction increases intensively during all periods of the experiment with the simultaneous suppression of reparative manifestation. It results in devastation of the organs of the immune system and can be considered as an equivalent to the secondary immunological insufficiency.
The paper reports a case of cystinosis with the involvement of kidneys, myocardium and liver in a female of 43. Late development of kidney failure might be due to a partial deficiency of the enzyme responsible for a cystine transport in the cell.
The authors relate the results of examining 149 men suffering from duodenal ulcer. The main group was made up of 75 patients given parenteral etaden treatment combined with conventional therapy. A study was made of the dynamics of clinical manifestations, the level of total protein and its fraction in the blood, protein metabolism (by radionuclide technique). Pieces of the duodenal mucosa from the periulcerous area were examined under microscope. Scanning and electron microscopy was also performed. Based on the data obtained it is concluded that etaden had active influence on protein synthesis, which favoured more rapid regression of the ulcerous defect in the main group patients. Morphological studies have also shown the positive dynamics of the regenerative process.
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Dynamics and character of interrelations of destructive and reparative processes in the liver in different conditions of acute experimental peritonitis (AEP), using preparations, inhibiting or stimulating these reactions in the experiment with 135 white rats have been studied. It was established the dependence of the level of destruction and intensity of hepatic reparative regeneration on the gravity of peritoneum affection, the level of toxicity and the state of the body immunologic reactivity. The organ reparation in normal AEP in the first two days is carried out mainly by intercellular hyperplasia of hepatocyte ultrastructures. Karyokinetic cellular activity is increasing from the 3rd day and reacting its peak on the 4-5 day of the experiment. The course of peritonitis while introducing azathioprine is accompanied by prevailing destructive-purulent changes in the liver. On the contrary, levamisole administration in experimental animals causes an increase in lymphoid-cellular infiltration of stromal and parenchymatous cells with earlier reparation of necrotic foci.
In experiments on 135 albino rats, present-day techniques were used to examine the time-course of hepatic destructive and reparative processes during various courses of acute experimental peritonitis (AEP). The magnitude of destructive changes in the liver was found to be directly related to the severity of peritoneal lesion, degree of intoxication, and immunologic reactivity of the body. Within the first 4-5 days of AEP, the liver was regenerated mainly by intracellular hyperplasia. On days 3-4 the mitotic activity of hepatocytes markedly increased, reaching its maximum on day 5 of the experiment. Destructive and suppurative changes predominated over reparative ones in the organ in AEP treated with the immunodepressant azathioprine. In contrast, the administration of the cellular immunity stimulant, levamisole++, to the experimental animals was followed by drastically increased mononuclear infiltration, hepatic stromal cell proliferation and reparative hepatocyte regeneration.
Therapy of patients with chronic atrophic gastritis using intragastric SMC-electrophoresis of cobamamide resulted in a marked clinical effect. Altogether 82 patients were investigated. Protein metabolism using I131-albumin and reparative regeneration (histochemical and electron microscopy methods) was studied in the course of treatment. A positive time course of protein metabolism determined by albumin and improvement of reparation of specialized epitheliocytes in the mucous membrane of the stomach were noted as a result of therapy.
Clinical and morphologic manifestations of a rare disease developing, as a rule, in early life--an infantile variant of Niemann-Pick disease--are illustrated with a fatal case of a 6.5-month-old child. The diagnosis was established histochemically using, in particular, Smith-Dietrich method which provided differential diagnosis with cerebroside lipidosis (Gaucher's disease). In addition to typical enlargement of the liver, spleen and lymph nodes, cerebral and adrenal affection there appeared true porencephalia.
A case of nephropathic cystinosis (Abderhalden-Lignac-Kaufmann disease) in a 8-month girl is reported. Features of pathomorphologic changes in the viscera are described, in kidneys, in particular. The changes described occur not only in the renal tubular system, but also in the glomeruli with the development of sclerosis in them, are more common in older children and may be considered as an intermediate form of cystinosis.
Krabbe's globoid leukodystrophy was observed in a girl of 6 months. The pathological diagnosis of the disease is based on the oligodendroglia cell damage, nerve fibre demyelinization and presence of giant multi-nuclear globoid cells.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.