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Biomedical subjects

E L Crews

Publications and source records attributed to E L Crews.

13 recordsLinked to original sources
PubMed1986

Capgras syndrome: a literature review and case series.

The authors have presented a description and review of the Capgras Syndrome along with data from a case series of 25 patients with misidentification syndromes (24 Capgras Syndrome, 1 Fregoli Syndrome). From this data, the following conclusions can be drawn: The Capgras Syndrome is not a rare condition, but an uncommon one which is probably frequently overlooked. The misidentification syndrome is not important as a diagnostic entity. It appears in a variety of psychiatric and neurologic conditions. Capgras Syndrome appears to have a possible neurological link in clinicopathological studies; it has been correlated with lesions which produce prosopagnosia. Capgras Syndrome seems to occur more frequently in women, blacks and schizophrenics. Capgras Syndrome had a high (15%) incidence in our adult inpatients diagnosed as having schizophrenia. From this figure we estimate a 0.12% prevalence of Capgras Syndrome in the general population. Capgras Syndrome is often associated with medical illness and when found should signal the alert clinician to investigate for occult organic conditions.

Adult↗
PubMed1984

Focal changes in cerebral blood flow produced by monetary incentive during a mental mathematics task in normal and depressed subjects.

The purpose of this experiment was to determine the effect of incentive-induced arousal on the diffuse and regional cerebral blood flow (rCBF) response during cognitive activation for normal and depressed groups. Two normal rest CBF measurements were followed by two mental mathematics activation CBF measurements. For the first activation measurement, half the subjects in each group were offered monetary incentive for correct performance and half the subjects received no monetary incentive. All subjects were offered monetary incentive on the final activation run. The effect of monetary incentive on the first activation run was to increase CBF activation at four detectors in the left hemisphere. Incentive did not affect the CBF activation response when introduced following practice on the activation task (on the final run). Depressed groups had lower resting blood flow than normals, but the distribution of flow and the CBF response to incentive were almost identical in the two groups.

Adult↗
PubMed1982

Kinetic evidence for decreased methionine adenosyltransferase activity in erythrocytes from schizophrenics.

We have observed significantly lower kinetic parameters (KM and Vmax) for methionine adenosyltransferase activity in erythrocytes obtained from early onset schizophrenics when compared to samples from normal subjects. These differences are apparently not due to differences in S-adenosylmethionine (SAM) utilization. These results offer an explanation for the conflicting reports of previous investigators and support the concept that undermethylation may characterize some forms of schizophrenia. Methylation is involved in multiple aspects of metabolism and although similar differences in the MAT enzyme in the brain have not been reported, such a deficit could have profound effects on the nervous system. Decreased availability of SAM could decrease catecholamine metabolism or rates of phospholipid methylation.

Erythrocytes↗
PubMed1981

Manic depressive illness concomitant with antisocial personality disorder: six case reports and review of the literature.

Six cases of young adults are reported who have manic depressive illness, manic type, and meet research criteria for antisocial personality concomitantly. The manic behavior of these patients responded to lithium carbonate. The literature is reviewed and documents lithium response in aggressive behavior and antisocial personality. A further clinical finding is an unusually high rate of homosexual prostitution. The authors conclude antisocial personality does not preclude mania.

Adult↗