E L Dai | PubMed Health

PubMed2001

[Experimental study on effect of fuzheng yiliu decoction on tumor cell cycle and telomerease].

OBJECTIVE: To study the mechanism of anti-tumor effect of Fuzheng Yiliu Decoction (FZYLD). METHODS: S180 neoplasm strain was inoculated in Kunming mice to establish model of S180 solid tumor. The model animals were treated with FZYLD by gastrogavage, the cell cycle of tumor were checked up by flow cytometer and the telomerease kit was used to test telomerease activity. RESULTS: The stage G0/1 ratio of tumor cells in model animals treated with FZYLD increased, while cells of S stage decreased, with telomerease activity inhibited. These changes were different significantly from those in the model animals treated with normal saline (P < 0.001). CONCLUSION: FZYLD could block the tumor cell proliferation procedure and inhibit the DNA synthesis and duplication in tumor cell. And the suppression of telomerease activity might be one of the mechanisms affecting the tumor cell proliferation cycle.

Animals↗

PubMed1994

[Study on efficacy of adult primary nephrotic syndrome with TCM-WM therapy and its hemorheologic effects].

The efficacy of TCM-WM therapy in treating adult primary nephrotic syndrome in comparing with using Western medicine alone and its influence on patient's hemorheology was investigated. The results showed that with the therapy of combined therapy the clinical remission rate and total effective rate were 65.4% and 88.5%, while that of Western medicine alone were 37.0% and 59.3% respectively. There was significant difference between the above-mentioned two groups (P < 0.01). Adverse effect scores with combined therapy were much lower than that of WM alone (P < 0.01). The recurrence rate of the illness with TCM-WM and WM therapy were 7.25% and 53.13% respectively (P < 0.01). Furthermore, the combined treatment of TCM-WM could remarkably improve the blood viscosity and reduce the content of fibrinogen. It was suggested that Syndrome Differentiation with the administration of steroid could not only ameliorate the adverse effects of steroid but promote the efficacy and reduce the recurrence of the disease. Besides, the addition of blood-activating and stasis-removing herbs could also improve the blood viscosity and the impaired fibrinolysis.

Adult↗