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Biomedical subjects

E L Gonçalves

Publications and source records attributed to E L Gonçalves.

At least 19 recordsLinked to original sources
PubMed1993

[Experimental study of fecal excretion of nitrogen in different nutritional conditions].

Fecal nitrogen excretion in different nutritional conditions were studied in 32 adult Wistar rats, casually distributed in four groups: group A (12), with normal control rats; group B (6), with subcutaneous impalnt of Walker-256 carcinosarcoma, at the beginning of the experiment; group C (8), with tumor implant eight days before the experiment beginning; group D (6), with standard skin wound in 15th day. The animals were fed with normoproteic diet (25% casein content). Nitrogen ingestion and urinary and fecal excretion were daily measured. Evaluation selected parameters were: nitrogen ingestion and urinary, fecal and total excretion; nitrogen fecal excretion/ingestion, nitrogen fecal excretion/urinary excretion and nitrogen fecal excretion/total excretion ratios; nitrogen urinary excretion/ingestion and nitrogen urinary excretion/total excretion ratios. Adequate statistical analysis was done with p < 0.05 critical limit value. It was observed that in normal animals nitrogen fecal excretion was equal to 5.7% ingestion value, 12.0% urinary excretion and 10.8% total excretion. In presence of malignant tumor, nitrogen fecal excretion was equal to 79% of normal animals value. In rats with skin wound in cicatrization nitrogen fecal excretion was 70.5% of normal animals value.

Animals↗
PubMed1989

Effect of diets with different protein levels on the growth of Walker 256 carcinosarcoma in rats.

1. The effect of different nutritional situations on the growth of experimental Walker 256 carcinosarcoma was investigated in rats. Fifty adult male Wistar rats were randomly assigned to three groups: group NN received standard chow throughout the experiment; group DD initially received an isocaloric protein-free diet, and some of the animals in this group (DN) were fed normal chow from the 37th to the 53rd day of the study. 2. On the 42nd day of the experiments all animals were inoculated subcutaneously in the flank with 2.5 to 3.0 x 10(5) viable Walker 256 carcinosarcoma cells and tumor growth and rat body weight were monitored daily thereafter. 3. Significantly greater tumor growth was detected in well-nourished (group NNT) as compared with malnourished animals (group DDT), but not in protein-depleted-refed (group DNT) animals, whose tumor growth was not significantly different from that of constantly malnourished (group DDT) rats. 4. Comparison of tumor weight and of the tumor weight/carcass weight (TW/CW) ratio showed no significant difference between malnourished and malnourished/refed animals, whereas well-nourished animals showed higher tumor weight and TW/CW ratios. 5. TW/CW curves for malnourished rats were parallel to those for malnourished/refed rats. TW/CW curves for constantly malnourished rats differed from those for well-nourished rats during the first observation period but there was no difference during the second week of tumor growth. 6. Although the protein-free diet inhibited tumor growth and refeeding enhanced it, carcass weight increased at the same rate, and therefore no change was observed in the TW/CW ratio.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1979

[Effects of choledochal perfusion with biliary acid solutions on activity of the sphincter of Oddi (author's transl)].

The changes of sphincter of Oddi's resistance, induced by choledochal perfusion of conjugated (taurocolic) and non-conjugated (colic) biliary acid solutions, in anesthetized dogs, were studied. The perfusions were made at a constant flow and intracholedochal pressures were registered. The mean number of contractions per minute, the mean maximal pressures and the mean minimal pressures in each study periods were analysed. The choledochal perfusion with the biliary acids solutions induced a slight but significative increase in sphincteric resistance. After 15 minutes, the perfusion with colic acid solution induced maximal pressures significantly more elevated than the ones observed with taurocolic acid solution. The non-conjugated solution induced a pressure tracing significantly distinct from the tracing observed with the conjugated acid solution. No changes in resistance were observed with a 2% NaCl solution. This implies that the observed changes in resistance were not related to osmotic stimulation of the sphincter of Oddi.

Ampulla of Vater↗