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Biomedical subjects

E L Hersch

Publications and source records attributed to E L Hersch.

6 recordsLinked to original sources
PubMed1988

Acute confusional state with status petit mal as a withdrawal syndrome--and five year follow-up.

A 55 year old man developed an acute confusional state with grossly impaired short-term memory accompanied by a Status Petit Mal epilepsy pattern on EEG, one to two weeks after abruptly discontinuing a large amount of oxazepam and a smaller amount of alcohol. Both his mental status and EEG pattern normalized markedly after intravenous diazepam. On 5 year follow-up the patient was seizure-free and medication-free without any significant residual cognitive deficit.

Acute Disease↗
PubMed1980

Relationships between psychological measurements and cerebral organic changes in Alzheimer's disease.

Twenty-two patients were carefully defined as having progressive dementia without other known cause and not complicated by clinical or laboratory evidence of multiinfarct dementia. Their degree of dementia measured by the ESD correlated highly with EEG disturbance (r=-0.79). The LPRS correlated 0.73 with ventricular enlargement. Although the EEG and CT scan only correlated significantly with each other in advanced cases, a combined index of EEG and CT Scan change, (Physical Measures Index) achieved a correlation of 0.93 with a combined index of psychological change (Psychological Measures Index). The results indicate the possiblity of using physical and psychological measures to monitor quantitative change in Alzheimer's Disease, the EEG contributing more initially and the CT scan more in the most advanced cases.

Alzheimer Disease↗
PubMed1979

Development and application of the extended scale for dementia.

As part of an interdisciplinary study of organic dementia, a psychologic test for assessing the degree of dementia--the Extended Scale for Dementia--was developed through the expansion and rescoring of the original Mattis Dementia Scale. Statistical analyses of the 23 test items resulted in a scoring scheme which includes the "weighting" of items for scoring purposes. The test was successfully administered to 90 subjects from 6 hospitals in the London (Ontario) region. With use of the Extended Scale, it was possible to discriminate between dementia and non-dementia groups of psychogeriatric inpatients and to correlate the findings closely with those of another measure of the degree of dementia, viz, the London Psychogeriatric Rating Scale (Ment.). Dementia patients who were retested after 6-month and 12-month intervals showed a significant decline in scores. No significant scoring differences were noted between males and females or between Alzheimer dementia and multi-infarct dementia.

Aged↗
PubMed1978

Clinical value of the London Psychogeriatric Rating Scale.

The London Psychogeriatric Rating Scale (LPRS) was developed in answer to the demand for a reliable psychometric rating scale suited to a psychogeriatric population. All inpatients on a Psychogeriatric Unit (approximately 140 at any specific time) were rated with the LPRS every third month for an 18-month period. The 4 components of the total score include a measure of mental status originally derived by factor analysis. Predictive validity has been established in terms of various clinically relevant areas including the following: a) ward placement; b) outcome (continued hospitalization, discharge, or death); c) diagnosis (by scoring levels and progress patterns across time); and d) ability of the patient to function in, or benefit from, a particular treatment program. The scale has been used successfully to assess a given patient's progress quantitatively and globally over a long period.

Aged↗