Tuberculin testing in the pediatric office and clinic.
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Biomedical subjects
Publications and source records attributed to E L Kendig.
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One hundred sixteen children, including 50 less than 10 years of age, received isoniazid therapy for tuberculous infection. Determinations of serum glutamic oxaloacetic transaminase concentrations at time of institution of therapy, 6 to 20 weeks later, and again at the completion of the therapeutic course, showed no evidence of hepatotoxicity. Clinical symptoms were never such that discontinuation of therapy was necessary.
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Since tuberculosis is still a significant threat, the family physician needs to be familiar with methods of its diagnosis and treatment. Among other entities discussed are atypical mycobacteriosis sarcoidosis, and cystic fibrosis.
Of 28 children with sarcoidosis, who have a mean follow-up period of approximately nine years, five (18 percent) have sustained severe damage from the disease. Two of these patients suffer from blindness, and three others have severe restrictive pulmonary disease. There has so far been no fatality. The presence of cutaneous lesions suggests a guarded prognosis, but the effectiveness of corticosteroid therapy cannot be accurately determined. The degree of pulmonary involvement evident on the chest x-ray film at the time of diagnosis is not always indicative of the ultimate prognosis.
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