The unusual role of the kidney during intoxication of monkeys by intravenous staphylococcal enterotoxin B.
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Animals↗
Biomedical subjects
E L Morris
Publications and source records attributed to E L Morris.
Effect of staphylococcal enterotoxin B on the electroencephalogram of monkeys.
A highly purified preparation of staphylococcal enterotoxin B was administered intravenously, 1 mg/kg, to rhesus monkeys. Electroencephalograms (EEG) were recorded from electrodes attached to the skin or implanted on the dura. The dose of toxin employed consistently produced a sequence of vascular collapse followed by death; in control studies, animals were bled periodically to produce a similar pattern of shock. Regardless of the time to death following administration of the enterotoxin, there were essentially no changes from base line EEG patterns until shortly before death. With the development of preterminal severe shock, there was a marked decrease in EEG wave frequency and an initial increase in amplitude. The latter diminished progressively to produce an isoelectric tracing immediately prior to death. This could be reversed for a brief period by epinephrine. An identical sequence of EEG changes was observed during the terminal period of hemorrhagic shock. It is postulated that cerebral anoxia, caused by inadequate blood flow, is the primary cause of the altered EEG patterns that accompany enterotoxin toxicity. In this respect, staphylococcal enterotoxin B produces changes apparently similar to bacterial endotoxin but distinctly different from the EEG effects reported after botulinum toxin, anthrax toxin, or rattlesnake and cobra venom.
Animals↗
A review of portal screen-film technology and five radiologists' evaluations of some existing products.
Portal radiographs, radiographs made to document the accuracy of radiotherapy treatment fields, are typically of poor image contrast. Recently, a new portal film and screened-cassette system was marketed, the Kodak EC-L system, with the claim of greatly improved image contrast. This new EC-L system was tested on a canine cadaver exposed to Cobalt-60 teletherapy gamma radiation, and image quality was compared to earlier marketed Kodak portal film products. The EC-L system was found to provide portal images of improved contrast/quality.
Animals↗
The relationship of spirituality to coronary heart disease.
Several studies suggest that religious involvement or spiritual well-being may affect health outcomes. This study was designed to investigate whether the scores from a questionnaire measuring spiritual well-being correlated with progression or regression of coronary heart disease as measured with computerized cardiac catheterization data. Participants in Dr Dean Ornish's Lifestyle Heart Trial were given the "Spiritual Orientation Inventory." A significant difference was found in the spirituality scores between a control group and a research group that practiced daily meditation. The spirituality scores were significantly correlated with the degree of progression or regression of coronary artery obstruction over a 4-year time period. The lowest scores of spiritual well-being had the most progression of coronary obstruction and the highest scores had the most regression. This study suggests that the degree of spiritual well-being may be an important factor in the development of coronary artery disease.
Attitude to Health↗