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E L Rowe

Publications and source records attributed to E L Rowe.

15 recordsLinked to original sources
PubMed1979

Anomalous solution behavior of 2-palmitate esters of lincomycin and clindamycin.

The aqueous solubilities of lincomycin and clindamycin 2-palmitate esters are compared. Clindamycin 2-palmitate hydrochloride has an unusually high solubility at 25 degrees, which is due to micelle formation. Both compounds are surface active with relatively low critical micelle concentrations. However, since the Krafft point of lincomycin palmitate is approximately 43 degrees, it does not form micelles below that temperature and appears to be quite insoluble until heated above 43 degrees. The experimental monomeric solubilities of the two compounds agree with calculations based on group contributions to lipophilicity. Clindamycin 2-palmitate hydrochloride solutions are quite sensitive to ions, being salted out as unprotonated base in the form of oily droplets. Salting out correlates well with anionic strength, which is quite constant for the various salts studied. A viscosity maximum occurs with increasing salt addition, with the peaks of the different salts occurring at the same anionic strengths.

Clindamycin↗
PubMed1977

Rapid acetylation of a dihydroxy compound by 4-(dimethylamino)pyridine catalysis: application to GLC determination of clindamycin palmitate hydrochloride.

The acetylation of clindamycin palmitate hydrochloride, preparatory to GLC assay, was accelerated greatly by the use of 4-(dimethylamino)pyridine as a catalyst. The reaction time was reduced from 2.5 hr at 100 degrees using pyridine and acetic anhydride to 30 min or less at ambient temperature upon addition of excess catalyst.

Acetylation↗