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Biomedical subjects

E L Spierings

Publications and source records attributed to E L Spierings.

8 recordsLinked to original sources

Headaches in patients with traumatic lesions of the cervical spinal cord.

We established the occurrence of headache in a group of 20 patients with traumatic transections of the cervical spinal cord. All but two patients had complete sensory lesions at levels varying from C2-3 to C7-8. Only three patients claimed to have no headaches at all although one of them had nuchal pains with fever. Twelve patients had "bladder" or "bowel headaches" or had had them in the past. These headaches were mostly generalized, throbbing or pounding in nature and severe in intensity. They were caused by obstruction of urinary flow and fecal impaction, respectively, and were associated with autonomic dysreflexia. Otherwise the headaches reported by the patients were mild although frequent in four, i.e once per week or more. These headaches were also mostly bilateral and lasted a relatively short time, i.e. less than one or two hours. The causes of these headaches were nonspecific for the group studied except for stimulation of the body which, however, probably depended on a mechanism similar to that of the bladder and bowel headaches. Migraine, either classic or common, was not reported by any of the patients.

Adult

Familial cluster headache: occurrence in three generations.

We report the occurrence of cluster headache in three generations of one family: an 8-year-old boy with primary chronic cluster headache, his 42-year-old father with secondary chronic cluster headache, and his 73-year-old paternal grandfather with episodic cluster headache.

Adult

Episodic and chronic paroxysmal hemicrania.

Chronic paroxysmal hemicrania has gradually become a well-established headache entity. However, the fact that the condition can also occur episodically is less well known. Both episodic and chronic paroxysmal hemicrania respond well to treatment with indomethacin. This makes it particularly important to recognize these conditions and to differentiate them from cluster headache, which is treated with other medications than indomethacin. In this article we describe additional cases of episodic and chronic paroxysmal hemicrania to illustrate the clinical features of these conditions.

Cluster Headache

Effect of ergotamine on cranial arteriovenous shunting in experiments with constant flow perfusion.

The effect of the antimigraine drug, ergotamine, was studied on the distribution of flow throughout the cranial microcirculation of the cat, using microspheres suitable in size to separate capillary flow from flow through the arteriovenous anastomoses. A constant flow perfusion experiment was used in order to eliminate the secondary effect of ergotamine on the microcirculation through a reduction in carotid blood flow per se. Under the experimental conditions, ergotamine decreased in a dose-dependent way the fraction of perfusion flow shunted through the arteriovenous anastomoses. This mode of action of ergotamine sheds new light on the so-called migraine shunt theory.

Animals

Effect of clozapine on the sleep pattern in the rat.

The effect of clozapine on the sleep pattern in the rat was studied after a single injection (2.5--20 mg/kg) and after daily administration for 11 consecutive days (2 X 20 mg/kg/day). After a single injection clozapine significantly suppressed REM sleep in a dose-related way, leaving slow wave sleep (SWS) unchanged. Follwing chronic administration, however, clozapine exerted its most prominent effect on SWS, the enhancement of which persisted for at least 3 days after discontinuation of treatment. REM sleep decreased with the development of tolerance and in the absence of rebound phenomena. The results are discussed in the light of disturbances in brain monoamines and the tolerance these amines developed to repeated administration of clozapine.

Animals