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Biomedical subjects

E L van Persijn van Meerten

Publications and source records attributed to E L van Persijn van Meerten.

10 recordsLinked to original sources

Patient and staff dose during CT guided biopsy, drainage and coagulation.

Patient and staff dose during CT guided coagulation of osteoid osteoma, tissue biopsy and abscess drainage were evaluated retrospectively on a conventional CT scanner and prospectively on a scanner equipped with fluoroscopic CT. The computed tomography dose index (CTDI) and the individual dose equivalent, i.e. the penetrating dose for workers at a depth of 10 mm tissue, were measured. Evaluation of CTDI enabled effective dose and maximum skin entrance doses for the patient to be determined. Doses were assessed for 96 CT guided interventions, including 16 drainages with average effective doses of 13.5 mSv and 9.3 mSv for the conventional CT scanner and the scanner with spiral CT fluoroscopy, respectively, 49 biopsies (effective doses of 8 mSv and 6.1 mSv, respectively), and 31 coagulations of osteoid osteoma (effective doses of 2.1 mSv and 0.8 mSv, respectively). Effective doses to patients were in the same range as those observed for regular diagnostic CT examinations. Entrance skin doses were well below the 2 Gy threshold for deterministic skin effects on the CT scanner equipped with fluoroscopic function (0.03-0.33 Gy), whilst skin doses on the conventional scanner were considerably higher (0.09-1.61 Gy). This is mainly owing to the fact that on the conventional scanner mAs was rarely reduced for scans evaluating needle position whereas low mAs per rotation was selected on the scanner with the fluoroscopy option. The maximum dose to a worker measured outside the lead apron was 28 microSv for one single procedure. The mean dose per procedure was below 10 microSv for radiologists and below 1 microSv for radiographers. Correcting for attenuation of the lead apron, the doses to workers are very low.

Biopsy↗

MRI of liver metastases: limitation of spleen-liver model in optimizing pulse sequences.

The spleen-liver model, as a predictor for contrast-to-noise ratio (C/N) in liver metastases, was verified for seven sequences in 22 patients with 70 colorectal metastases. Optimization of conventional spin-echo, T1-magnetization-prepared gradient-echo and fat frequency-selective presaturation inversion-recovery fast spin echo can be done using the spleen-liver model. C/N of liver-spleen and liver-metastases, however, differed significantly on our T1 gradient-echo and T2-weighted fast spin-echo images, with and without fat-selective saturation.

Adult↗

Accuracy of helical CT for acute pulmonary embolism: ROC analysis of observer performance related to clinical experience.

The aim of this study was to test the influence of observer experience on the accuracy for interpreting helical CT for acute pulmonary embolism (PE) and to identify sources of observer errors. Three observers of different expertise blindly assessed 147 helical CT scans for suspected PE (true status regarding absence or presence of PE known from independent reference studies). These observers were (a) an experienced CT radiologist, (b) a fellow in CT, and (c) a second-year resident without any formal training in CT. None of them had prior experience with CT for PE. Firstly, 70 CT scans were scored without revealing true PE status. Afterwards, feedback was provided and another 77 CT scans were evaluated. The CT scans were scored on a 5-point confidence scale and receiver-operator-characteristic analysis was performed. Different sources of interpretation errors were analyzed. The two observers with CT experience were significantly more accurate than the unexperienced observer. Their performance was not influenced by feedback training. Certain observer errors were identified, but there was no clear difference among the three observers considering the type of errors. There is significant influence of observer experience on accuracy of reading helical CT for PE: A basic working experience with whole-body CT seems to be a prerequisite. These results suggest that with this experience any radiologist should be able to achieve good accuracy; helical CT thus might become a suitable technique for acute PE in routine clinical practice.

Acute Disease↗

Comparison of inversion-recovery gradient- and spin-echo and fast spin-echo techniques in the detection and characterization of liver lesions.

PURPOSE: To compare respiratory-triggered inversion-recovery (IR) gradient- and spin-echo (GRASE) magnetic resonance (MR) imaging with respiratory-triggered T2-weighted fast spin-echo (SE) imaging in the diagnosis of liver metastases. MATERIALS AND METHODS: In this prospective study, two radiologists independently identified focal hepatic lesions on respiratory-triggered IR GRASE and respiratory-triggered fast SE MR images in 28 consecutive patients with 186 (135 malignant and 51 benign) proved lesions. A combination of findings at surgery, intraoperative ultrasonography (US), and histologic examination served as the standard of reference. Contrast-to-noise ratios (CNRs) were obtained from 86 lesions larger than 10 mm. RESULTS: The sensitivity in the detection of liver metastases was, independent of lesion size and observer, higher for IR GRASE imaging (55%) than for fast SE imaging (44%-50%) (observer 1, P = .014; observer 2, P = .21). Confidence levels with IR GRASE imaging were higher, but not significantly so, than those with fast SE imaging (P < .098). Both observers characterized liver lesions better with IR GRASE than with fast SE imaging (observer 1, P = .04; observer 2, P = .48). The metastasis-liver CNR was significantly higher (P = .012) with IR GRASE imaging. CONCLUSION: The respiratory-triggered IR GRASE sequence is a fast alternative to the respiratory-triggered fast SE sequence in the evaluation of suspected liver metastases.

Colorectal Neoplasms↗

Postnatal development and structure of the neurocentral junction. Its relevance for spinal surgery.

STUDY DESIGN: The early and late development of the neurocentral junction between the vertebral arch and the vertebral body was studied, and this structure was related to spinal surgery. OBJECTIVES: Because of its strategic position within the vertebral body, its structure could be of relevance for spinal surgery. During the positioning of cannulated pedicle screws and before penetration into the cancellous bone of the vertebral body, resistance had to be overcome inside the "pedicle" of the vertebral arch. Was this point of resistance related to the neurocentral joint? SUMMARY OF BACKGROUND DATA: Data on the fate of this developmental structure after age 3-6 years, the age at which it fuses, appeared to be missing in literature. METHODS: We examined dry bone and "fresh" vertebrae from individuals ranging in age from 0 to 75 years. Observations were recorded by means of gross anatomic photographs, micrographs, radiographs, and computed tomography scans. RESULTS: After fusion of the junction at age 3-6 years, its structure persists through life as a bilateral plate of bone extending from the cranial to the caudal anular epiphyses inside the dorsolateral parts of the definitive body. CONCLUSIONS: This plate may function as a support for pedicle screw fixation. Its form explains typical burst fractures of the vertebral body. Spondylolysis at this site is unknown.

Adolescent↗

Epi- and metaphyseal changes in children caused by administration of bisphosphonates.

Nitrogen-containing bisphosphonates (NCBs) are potent inhibitors of bone resorption and are used in the treatment of adults with various skeletal disorders. Little is known about their effects on the growing skeleton. The authors retrospectively studied the skeletal radiographs obtained in nine children before, during, and after NCB administration. Bandlike metaphyseal sclerosis and concentric epi- and apophyseal sclerosis developed in all patients. The extent of sclerosis depended on the duration of treatment and was related to local, and probably general, skeletal growth activity. In the maturing spine, NCBs caused a "picture-frame" or "bone-within-bone" appearance, depending on continuation or cessation of administration. In addition, metaphyseal undertubulation of long bones was noted in five patients. After discontinuation of bisphosphonate treatment and/or closure of the growth plates, the degree of sclerosis decreased, and sclerosis tended to disappear, indicating that this is a reversible phenomenon.

Adolescent↗

MRI of tuberculous spondylitis.

Four patients with paravertebral extension of advanced tuberculous intervertebral disk-space infection were studied by CT and MRI. In one patient gadolinium-DTPA (Gd-DTPA) was administered intravenously as a paramagnetic contrast agent. MRI showed the disk-space abnormalities and extension of the inflammatory process to best advantage in the coronal plane. This plane demonstrated in one image the spinal localization and the paravertebral extension of the inflammation. Gd-DTPA assisted in delineating the communication of the vertebral and paravertebral components of inflammation. This phenomenon introduces an additional diagnostic element into the evaluation of spondylitis. Although the features of advanced tuberculous spondylitis are conspicuously well shown with MRI, further experience is needed to evaluate the potential of MRI in detecting early tuberculous spondylitis in relation to nontuberculous spondylitis.

Adolescent↗

Magnetic resonance imaging of the genitourinary tract.

This is an overview of the current applications of magnetic resonance imaging (MRI) in the genitourinary tract based on the experience with the 0.5-Tesla MR scanner (Gyroscan, Philips) at the Leiden University Hospital and on reports in the literature. MRI appears to share some of the limitations of CT. MRI cannot reliably differentiate between a malignant and a benign tumor. In the staging of ovarian malignancies by means of MRI, bowel preparation would be desirable. On the other hand, the soft-tissue contrast resolution of MRI is superior to that of CT and images can be obtained in any plane. Thus MRI promises to be an accurate method for staging malignancies. The results in the examination of transplant kidneys are encouraging. We expect that there will be a place for MRI as a complementary technique to ultrasonography in the diagnosis of scrotal disease.

Female↗