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Biomedical subjects

E Löhr

Publications and source records attributed to E Löhr.

At least 37 records · Page 2Linked to original sources

Unusual cause of recurrent arterial embolism: floating thrombus in the aortic arch surgically removed under hypothermic cardiocirculatory arrest.

A 46-year-old fully active, asymptomatic man suffered two episodes of major peripheral arterial embolism within 2 months. Heart disease was ruled out by appropriate investigations. Further diagnostic evaluation (angiography, CAT scan) revealed the extremely rare finding of a "floating mass" in the transverse aortic arch suspected to be the source of embolization. This mass was successfully removed using the technique of hypothermic cardiocirculatory arrest. The histological diagnosis was an aged intraluminal thrombus and moderate atherosclerosis of the thoracic aorta. For prevention of recurrent arterial embolism in cases without an initially apparent cause and site of origin, a thorough diagnostic, and in a given patient, an aggressive surgical approach for the elimination of the embolic source are advocated.

Aorta, Thoracic↗

[Glucagon as an adjuvant to infusion cholecysto-cholangiography].

The effect of glucagon on the results of intravenous cholangio-cholecystography (IVC) was studied in a randomised trial on 246 patients. The injection of 1 mg. glucagon increased the speed of contrast excretion from the liver. This led to a significantly quicker demonstration of the gallbladder, with a tendency to more rapid filling of the biliary ducts. In patients with hyperbilirubinaemia there were somewhat fewer negative cholangiograms and significantly fewer negative cholecystograms. Considering the patients as a whole, the use of glucagon has the advantage of reducing the time taken for the examination and of a reduction of negative IVCs. Since glucagon has practically no side effects, our experience suggests that it can be recommended as an adjuvant to IVC. Improvements in IVCs are particularly significant since they are now only used for special indications.

Cholangiography↗

[Radiological diagnosis of late effects on thoracic organs after chemotherapy and/or radiation therapy as well as after radionuclide therapy].

With respect to the considerable risk involved in oncologic therapy methods, especially when bleomycin is administered, a specific observation of the possibly fatal side effects is necessary. As, for example, a regression of pulmonary alterations caused by bleomycin is possible when they are detected early, the call for early recognition of developing lesions is becoming more and more urgent. Conventional radiologic diagnosis is scarcely important in early recognition, but X-ray computed tomography is a suitable imaging method because it is able to visualize tiny intrapulmonary and pleural alterations. The CT image of bleomycin pneumopathy is variable. There are irregular, partly sharply defined nodular structures. They are generally found in peripheric sites near to the pleura with the exception of the pleura mediastinalis. Contrary to functional investigations such as the determination of the CO diffusion capacity which are equipment- and cost-consuming, X-ray computed tomography does not only offer a qualitative information on an existing pneumopathy, but provides also a precise localization of these pulmonary alterations. Computed tomography is a method for the quantitative assessment of the peripheral lung density with the same amount of information as the measurement of the gas transfer per pulmonary volume unity. However, it offers the advantage of a simultaneous qualitative visual judgement of the organ, i.e. not only the types and dimensions of pulmonary lesions can be assessed, but the physiologic effect of these lesions, i.e. the pulmonary function, can be determined by quantitative density measurement, too. Thus quantitative computed tomography represents an alternative in the assessment of the pulmonary function. According to the recommendations of Bellamy et al., it should be combined to routine computed tomography of the thorax. The method of choice for the diagnosis of anthracycline cardiotoxicity is radionuclide ventriculography. A decrease of the left ventricle expulsion to less than 45% is considered as a critical value. However, cardiac side effects of cytostatic drugs can be detected early in the individual course, so that late effects in the sense of irreversible cardiomyopathy are prevented.

Adult↗

[Value of plain x-ray procedures in the diagnosis of ocular muscle paralysis].

Out of 444 patients with paralysis of the eye muscles 187 were examined by plain X-ray films, 144 of were reviewed in order to address the question, whether the X-ray examination was able to elucidate etiology and pathogenesis of the paralysis. Of 444 patients we found positive results in only 14 per cent. Among traumatic, tumorous or inflammatory lesions we found positive results in 47 to 84 per cent of the patients, so that there was reasonable influence on the following diagnostic procedure. Plain films were rarely able to establish a definite diagnosis suitable for therapy. By comparison, computed tomography delivers additional information, so that special procedures could be omitted. In spite of that plain films of the skull should be the first step of the diagnostic algorithm, because they give the right direction to the subsequent expensive procedures.

Humans↗

[Embolization therapy of kidney tumors--experience with a group of 60 patients].

A series of 60 patients is reported, in whom embolization was carried out because of a kidney tumor. In 9 cases, this treatment was given for purely palliative reasons, but in the remaining 51 cases, this treatment was a preoperative measure in order to achieve coagulation or "dry the tumor out" intra vitam. Although we formerly used materials such as gel foam and muscle homogenates, in the last three years, Ethibloc or pure alcohol has been used exclusively. The risks involved in this therapy are discussed. In patients with large arteriovenous shunts or fistulas, alcohol should not be used and we prefer polyacrylic agents like Ethibloc.

Carcinoma, Renal Cell↗

[Renovascular hypertension--diagnosis and therapeutic possibilities].

The causes of renal vascular hypertension are outlined. These are guided by the influence on the renin-angiotensin mechanism. The so-called essential hypertension is not infrequently caused by an early nephrosclerosis, which can be diagnosed very early through electrone microscopy. Renal artery stenosis, caused by fibrodysplasia or arteriosclerosis represents a special case of renal vascular hypertension which can be treated effectively by balloon catheter dilatation. The results in 240 patients are presented where these therapeutic principles were applied.

Angioplasty, Balloon↗

[Slit ventricle--clinical syndrome or radiologic phenomenon?].

Between 1976 and 1982 336 patients with an age range from several days to 65 years, were treated by ventriculo-atrial or peritoneal shunt, because of internal hydrocephalus of different origins. Regular computerized tomographies demonstrated slit-ventricles in 36 patients. Twenty-eight patients were free of complaints. In 8 patients there were symptoms like nausea and vomiting. In 5 patients these complaints were explainable by other diseases. In only 3 patients these signs were caused by increased intracranial pressure because of ventricular-catheter obliteration. In these 3 cases an enlargement of the ventricles at the time of obliteration was seen. In our series slit-ventricles were seen only as a radiological phenomenon. There was no necessity for neurosurgical treatment at all.

Adolescent↗

[Renal tumor diagnosis with ultrasound and CT].

The use of sonography and computer tomography has resulted in a marked change in the diagnosis of renal space occupying lesions. The value of these diagnostic tests is analyzed mainly in the diagnosis of solid kidney tumors. The possibilities and limitations are analyzed and the addition of further diagnostic procedures such as fine needle puncture and operative exploration are considered. A proper diagnostic work-up is outlined.

Adenocarcinoma↗

[Localization of enlarged parathyroid glands in hyperparathyroidism. Experiences with and role of computed tomography].

40 patients with primary hyperparathyroidism, 2 with and 38 without previous surgery had computed tomography (CT) and ultrasonography (US) preoperatively. CT correctly identified enlarged glands in 75%, US in 80%. In 7.5% US was correctly negative. In 12.5% CT has shown only a correct suspicion. Us was false positive in 2.5%, CT in 5%. US was false negative in 10%, CT in 7.5%.

Female↗