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Biomedical subjects

E Løntoft

Publications and source records attributed to E Løntoft.

16 recordsLinked to original sources
PubMed2000

Monitoring of free TRAM flaps with microdialysis.

The aim of this investigation was to follow the metabolism of free TRAM flaps using microdialysis. Microdialysis is a new sampling technique that provide opportunities to follow the biochemistry in specific organs or tissues. A double-lumen microdialysis catheter or probe, with a dialysis membrane at the end, is introduced into the specific tissue. Perfusion fluid is slowly pumped through the catheter and equilibrates across the membrane with surrounding extracellular concentrations of low molecular weight substances. The dialysate is collected in microvials and analyzed by an instrument using very small volumes. Glucose, glycerol, and lactate concentrations were measured in the flaps and compared with those in a reference catheter that was placed subcutaneously in the femur. The investigation continued 72 hr postoperatively. The study group consisted of 14 women who underwent reconstruction with a free TRAM flap, and one woman with a double TRAM flap. During flap ischemia, the concentration of glucose was reduced, while the lactate and glycerol levels increased. The differences between the flaps and controls were statistically highly significant. After reperfusion of the flaps, the concentrations of glucose, lactate, and glycerol approached normal. One flap failed because of an arterial anastomosis thrombosis. This was clearly demonstrated by the samples from the microdialysis: the concentration of glucose fell to an unmeasurable level; the concentration of lactate increased for a period before it stopped due to lack of glucose; and the concentration of glycerol increased to a very high level, probably because ischemia caused damage to the cell membranes of which glycerol is an important part. The authors concluded that microdialysis can detect ischemia in free flaps at an early stage, making early surgical intervention possible.

Breast Neoplasms↗
PubMed1999

[Sentinel node--malignant melanoma and primary breast cancer. The significance of sentinel node in the treatment of malignant melanoma and primary breast cancer].

Dissection of regional lymph nodes plays an important role in surgical treatment of melanoma and breast cancer. However, the dissection of regional nodes is connected with a high morbidity and dissection in the 50-75% of the patients, who have no regional metastases, represents an overtreatment. No diagnostic procedures are available which could select patients who should have a regional lymph node dissection. The sentinel node (SN) is the first node in the lymphatic basin that drains the primary tumour. SN can be localized by means of dye or isotope or a combination. SN can be localized in melanoma or breast cancer patients in 98% of the operations. In 0-1% (melanoma) or 0-5% (breast cancer) SN was false negative. In some melanoma centers SN technique is an established routine. If the SN is normal, no regional lymph node dissection is needed. In breast cancer technical improvements must be achieved before SN examination can be used routinely. Future studies must clarify if examination of SN could have clinical significance in other malignant tumour diseases.

Axilla↗
PubMed1999

Squamous cell carcinoma of the nasal vestibule.

From 1978 to 1992, 66 patients (32 women and 34 men) were treated for carcinoma of the nasal vestibule at Odense University Hospital. The treatment was radiotherapy (41 patients), surgery (13 patients) or a combination of the two modalities (12 patients). Twenty-one patients (32%) developed recurrence. Of these, 17 (81%) were diagnosed within the first two years of follow up. The recurrence rate was found to be correlated to the anatomic site of the tumour-origin; septal site of origin meant higher risk of recurrence. Five-year disease specific and crude survival of all patients were 87.0% and 58.5%, respectively. Several variables (sex, age, anatomic site of origin, Wang-classification, tumour volume and regional lymphnode metastases at time of diagnosis) were evaluated as possible prognostic indicators. In univariate analysis, regional lymph node metastases at the time of diagnosis and anatomic site of origin of the tumour showed a significant influence on survival. In multivariate analysis, septal origin of primary tumour was a significant, independent predictive factor of recurrence and the presence of lymph node metastases at the time of diagnosis showed to be a highly significant prognosticator of both disease specific and crude survival (p < 0.0001). We conclude that patients with primary lymph node metastases and septal location of primary tumour need intensive primary treatment and close follow up.

Adult↗
PubMed1998

[The value of palpation as basis for decision on lymph node excision].

The purpose of the study was to evaluate palpation of the regional lymph nodes in control examinations of patients with malignant disease. A retrospective review of the medical records of 188 cases in which the patients had had an extirpation of the regional lymph nodes was performed. We have compared the preoperative findings through palpation with the histological diagnosis. The patients were grouped according to the region in which the lymph node removal had been done. The specificity of palpation when the histological diagnosis was malignant was (with 95% confidence limits), in the axilla 0.65 (0.54-0.75), in the inguinal region 0.86 (0.75-0.94) on the neck 0.83 (0.52-0.98) and in the suprahyoid region 0.58 (0.28-0.85). In conclusion, palpation of regional lymph nodes is not a sufficient control examination in the estimation of the course of malignant disease. Supplementary examination methods are recommended.

Axilla↗
PubMed1991

Metastasis to the penis. Case reports and review of the literature.

Metastasis to the penis is rare, despite rich vascularization and complex circulation. Less than 200 cases have been reported. Three new cases of penis metastasis from primary tumours in the bladder and prostate, respectively, are described. The most common symptoms are penile induration and swelling. Treatments, all of which must be considered merely palliative, consist of local tumour excision, radiation therapy, cytostatic and hormone therapy, possibly with partial or total penis amputation. The prognosis is poor, irrespective of the therapy and site of the primary tumour. More than 80% of the patients die within six months after the occurrence of penis metastasis, as a result of disseminated cancer disease.

Adenocarcinoma↗
PubMed1986

[Long-term results after surgical treatment of pressure sores].

Thirty-one patients were operated on because of pressure sores. Twenty-five of these were investigated by means of an enquete. Twenty-two patients replied. In 9 of 22 patients recurrence of pressure sores took place during the observation period, the mean observation time being 35 months. It is concluded that operative treatment of pressure sores, with the methods employed here can be recommended when the conservative treatment is protracted, or the conservative treatment does not result in improvement, provided that the patient is fully aware that consistent relief of pressure is necessary in the postoperative period and the general condition of the patient permits this. Special attention is necessary in patients with repeated recurrences of pressure sores, to ensure that the aforementioned conditions are fulfilled, before surgical treatment. The treatment of repeated recurrences of pressure sores involves many days of hospitalisation, and therefore very high costs.

Adult↗
PubMed1985

Congenital nasal dermoid cysts and fistulas.

Eleven patients who underwent surgical excision of nasal dermoid cysts or fistulas are reported. The patients are discussed according to the aetiology, sex distribution, location on the nose, and possible inheritance. Our surgical results are satisfactory with only one case which required reoperation. We found that late diagnosed cysts had a higher frequency of deep involvement and therefore required more extensive surgery.

Adolescent↗
PubMed1984

Giant ventral hernias and their repair.

A method is described for the reconstruction of the abdominal wall in cases of large ventral hernia, by employing the frontal leaf of the rectus fascia and free fascia transplant, combined with muscle transposition. The results of 14 operations have been satisfactory in 11 cases, over an average observation period of 28 months. The method is recommended for very large ventral hernias, particularly in patients suffering from pulmonary symptoms, where reduction of the abdominal volume is undesirable.

Abdominal Muscles↗
PubMed1983

Calcifying epithelial odontogenic tumor (Pindborg tumor): an unusual case.

A case of the rare calcifying epithelial odontogenic tumor is reported. The tumor was situated high in the left maxillary antrum, bulging into the nasal cavity. The presenting signs were homolateral nasal stenosis and bulging of the lateral nasal wall. The clinical appearances and histological findings are submitted and compared with those in cases described previously. Treatment and prognosis are discussed. From the present case it is apparent that despite its odontogenic nature the tumor may occur so far from the teeth that clinically it may be mistaken for a tumor of the nasal cavity.

Constriction, Pathologic↗