Biomedical subjects

E Lampert

Publications and source records attributed to E Lampert.

46 records · Page 3Linked to original sources

PubMed1989

Acute effect of molsidomine on pulmonary circulation of patients with chronic obstructive pulmonary disease.

Chronic obstructive lung diseases (COLD) are very often complicated by pulmonary arterial hypertension and right heart failure. Several drugs including nitrates have been used to counteract this type of hypertension. Molsidomine (M) is a recent nitrates-like drug acting for a longer time than the classical nitrates. Our aim was to investigate whether M could significantly lower pulmonary arterial hypertension of patients suffering from COLD. Ten male patients were investigated before and after intake of 4.0 mg M given sublingually. Ventilatory and cardiocirculatory indices were measured at rest and during a 30 and a 50 watts exercise. During exercise, M significantly lowers pulmonary arterial pressure and pulmonary vascular resistance without detrimental effect on arterial blood gases. M seems to be a promising drug to counteract the pulmonary hypertension of patients with COLD.

Heart Failure↗

PubMed1988

Effect of molsidomine on the lung diffusing capacity of normal men.

Molsidomine (M) is a new antianginal drug which induces a peripheral venous pooling and decreases pulmonary artery and pulmonary venous pressures. The purpose of our study is to assess whether M influences the filling of the pulmonary capillary bed as estimated by the single-breath lung diffusing capacity (DLCO). DLCO was measured before and 10, 20, 30, 40, 50 and 60 minutes after sublingual administration of 2 mg molsidomine in six healthy men examined in sitting and supine positions. The blood flow distribution was estimated by means of radioactive xenon, in sitting position only, before and 30 minutes after M intake. M. induces a significant fall in DLCO from the 20th to the 60th minute which indicates an emptying of the pulmonary capillary bed. Concomitantly, blood flow is redistributed from the apices to the lung bases. We explain the decrease in DLCO by two mutually non-exclusive mechanisms: an outflow of the blood from the thorax to the periphery and a change in the lung-perfusion distribution. From a practical point of view, two conclusions may be reached. First, in coronary patients a decrease in DLCO and DLCO/VA may be due to the intake of vasodilating agents such as molsidomine and not to emphysema or lung fibrosis. Secondly, the measurement of DLCO is a useful tool to assess the action of a drug on the pulmonary circulation.

Adult↗

PubMed1987

[Pulmonary hypertension in patients with emphysema].

Fifty-three patients with chronic and stabilized emphysema, mostly of the panlobular type, and without any associated disease likely to interfere with the cardio-pulmonary function, were used to analyze the physiological factors responsible for their pulmonary hypertension, moderate at rest but marked at exercise. The study showed that the main responsibility for pulmonary hypertension, both at rest and during exercise, lay on mechanical respiratory factors and on passive regulation of the lesser circulation. It also showed that the predictive value of SaO2 was higher than that of PaO2 but lower than that of CvO2 which depends on a relative tissue hypoxia of cardiovascular origin responsible for vasoconstrictive acidosis at exercise. In this study, destruction of the pulmonary capillary bed, often different from destruction of the alveolar surface, had a predictive value for PAP higher than that of hypoxia. In these cases of pure, stabilized chronic emphysema hypoxia does not have the preponderant hypertensive role for which it is blamed in the literature in all circumstances.

Blood Gas Analysis↗

PubMed1986

Work rate-dependent lactate kinetics after exercise in humans.

Arterial blood lactate concentrations were measured on 19 subjects before, during, and after a 3-min bicycle exercise at several work rates, and the concentrations during the recovery phases were fitted to a biexponential time function consisting of a rapidly increasing and a slowly decreasing component. Highly significant correlations with the work rate of the exercise preceding the recovery were found for all the parameters of the fitted equation. The two velocity constants show inverse linear relationships, whereas the other parameters vary according to a definite power function. A functional meaning has been given to the two velocity constants, namely the ability of the tissues to exchange and to remove lactate. For the group of subjects studied, after exercises at work rates below about 3.5 W/kg, the tissue's ability to utilize, and possibly to exchange lactate, increases over values generally reported for resting conditions, whereas after exercises at higher work rates the inverse occurs. Lactate kinetics during recovery appear to be the result of two underlying processes, one enhancing the ability of the tissues to exchange and remove lactate and the other restraining it.

Adult↗

PubMed1975

[Criteria and validity of continuous measurement of pO2 and pCO2 in man].

After description of a method of continuous measurement of partial pressure of blood gases, the authors describe the technical difficulties : behaviour of the electrodes, problems associated with continuous measurement, and emphasise the influence of the method on the results, e.g. heparinisation, blood flow rate, quantity of blood consumed. The results obtained under suitable physiological conditions show the difficulty of interpretation of continuous measurement of gaseous parameters and show interest in short but significant function tests.

Blood Gas Analysis↗

PubMed1974