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Biomedical subjects

E Lamperti

Publications and source records attributed to E Lamperti.

At least 37 records · Page 2Linked to original sources

Madopar HBS and the decompensated phase of Parkinson disease.

The most important current problem in the treatment of Parkinson disease in the so-called L-dopa long-term-treatment syndrome. We present here the results of our experience with Madopar HBS in the treatment of two groups of patients suffering from L-dopa long-term treatment syndrome. In the first study we replaced the standard Madopar with Madopar HBS. In the second study, after identifying the most disabling "off" periods, we added Madopar HBS to the previous treatment in such a way as to control these "off" phases. Our study suggests that Madopar HBS is useful in reducing typical fluctuation phenomena in the majority of patients.

Adult↗

Typical and atypical forms of paroxysmal choreoathetosis.

Two children with clinical pictures of paroxysmal kinesinogenic choreoathetosis and paroxysmal dystonic choreoathetosis are described and compared with previous reports with regard to diagnostic procedures, therapeutic approach and prognosis. A third case, characterized by paroxysmal dyskinesia induced by exercise and associated with choreiform nonprogressive signs, is also described. Such an association has not been reported previously. This unusual clinical picture indicates the possibility of intermediate forms in the paroxysmal choreoathetosis group and suggests a relationship between paroxysmal motor disorders and benign familial chorea with early onset.

Adolescent↗

Neurobrucellosis mimicking multiple sclerosis: a case report.

A case of neurobrucellosis misdiagnosed at the onset as multiple sclerosis (MS) is presented. Magnetic resonance imaging showed multiple periventricular areas compatible with demyelinating lesions of possible vasculitic origin. Myelin basic protein was elevated in the CSF. The immunological CSF study was consistent with a chronic intrathecal inflammatory process. The modification of these parameters during specific treatment is also presented.

Brain Diseases↗

Transient paroxysmal dystonia in infancy.

A group of nine patients with paroxysmal non epileptic motor disorders, with onset in the first year of life, is presented. The characteristics of the attacks define them as paroxysmal dystonia. The progression of the symptoms showed a spontaneous remission in a short length of time (6-22 months) in most infants. In two of them the symptoms persist, showing, however, a progressive decrease. All the laboratory tests were normal. None of the subjects revealed neurological signs and psychomotor development was normal. A likely correlation between transient early-childhood paroxysmal dystonia and developmental processes is discussed.

Child Development↗

Cryptococcal meningoencephalitis: intrathecal immunological response.

The intrathecal immune response is reported in a patient with cryptococcal meningoencephalitis. CSF IgM and IgG levels were significantly related to the favourable clinical evolution. IgM response was specifically directed against the pathological agent, while IgG were mostly non-specific. The data are discussed and compared with the other chronic infections of the central nervous system.

Adolescent↗

Cryptococcal meningoencephalitis. Case report and review of Italian literature.

A case of cryptococcal meningoencephalitis, as presented by a hypertensive hydrocephalus, is described. To our knowledge, this is the 24th case described in Italy since 1953. The diagnosis was made with ventricular fluid examination: the patient was successfully treated with amphotericin B and 5-fluorocytosine, thus avoiding the risks of surgical treatment of hydrocephalus. Early diagnosis and proper therapy are necessary in order to decrease the high lethality of cryptococcosis.

Adolescent↗

Clinical usefulness of a dopaminergic agonist in headache diagnosis.

The dopaminergic system seems to be involved in pain modulation. In a 1983 publication, the administration of a dopaminergic agonist has been proposed as a test able to distinguish migraine from other cephalalgia. In the present study, 123 people were tested, 102 of them being migraine patients and the others being normal subjects. The test showed highly specificity for headache patients when compared to normal subjects, and was highly specific for migraine patients when compared to headache patients. Data are discussed considering the clinical diagnostic value, pathophysiological and therapeutic aspects.

Adolescent↗

Naloxone in cerebral ischemia: preliminary data.

The effect of the opiate antagonist naloxone was evaluated in 11 unselected patients with cerebral ischemia. Naloxone reversed neurological deficits in the 4 patients with less evident signs of vascular damage.

Adult↗

Spinal cord involvement and systemic lupus erythematosus: clinical and magnetic resonance findings in 5 patients.

We report the clinical, magnetic resonance imaging (MRI) and laboratory findings in 5 patients with clinical spinal cord involvement with an acute or subacute course; in two of the patients the myelitic episode preceded, in one it was concomitant to, and in two it followed the diagnosis of systemic lupus erythematosus (SLE). The marked clinical and MRI heterogeneity detected in our patients suggests that various factors may be implied in the pathogenesis of spinal cord involvement in SLE. The possibility of a future evolution to SLE should be kept in mind in women presenting spinal cord involvement with no other explanation, and should be assessed by means of extensive and repeated clinical and laboratory evaluations.

Adolescent↗