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Biomedical subjects

E Leuthold

Publications and source records attributed to E Leuthold.

18 recordsLinked to original sources
PubMed1986

[Ranitidine therapy of duodenal ulcer: comparison of once-a-day and twice-a-day administration. A Swiss multicenter double-blind study].

In a Swiss multicenter double-blind trial ranitidine was given in doses of 300 mg nocte and 150 mg b.d. for the treatment of duodenal ulcer. Ninety-seven patients with endoscopically proven ulcer were treated for four, and in cases of non-healing for eight, weeks. Cumulative healing rates with 300 mg and 2 X 150 mg were 77% and 78% after four weeks and 90% and 94% after eight weeks respectively. 60 and 65% of the patients were asymptomatic after four weeks. Smoking did not adversely affect healing. Thus, ranitidine in a dose of 300 mg nocte is as effective as ranitidine in a dose of 150 mg b.d. in the treatment of duodenal ulcer.

Adolescent↗
PubMed1985

[Misoprostol and cimetidine in the treatment of duodenal ulcer. A multicenter Swiss double-blind study].

The efficacy and tolerance of misoprostol a synthetic prostaglandin E1 analogue-and of cimetidine were evaluated in the treatment of duodenal ulcer following a double blind multicenter design. A group of Swiss gastroenterologists recruited 119 patients with endoscopically proven acute duodenal ulcer. They were enrolled and treated according to a uniform protocol either with misoprostol 4 X 50 micrograms daily, with misoprostol 4 X 200 micrograms daily or with cimetidine 4 X 300 mg daily. Patients who were healed after 4 or 8 weeks were followed during 6 months. Cumulative healing rates at 4 weeks in groups receiving misoprostol 200 micrograms, misoprostol 800 micrograms or cimetidine 1200 mg daily were 42%, 58% and 71% respectively. Patients treated with cimetidine showed a more rapid improvement of symptoms than patients treated with misoprostol. Symptomatic recurrences after ulcer healing occurred in almost 40% of the patients within 6 months, irrespective of the type of acute ulcer treatment. Risk factors for slowed healing and increased rate of recurrence were evaluated in the present study, and the results were compared with the results of two previous trials performed according to a similar protocol. Smoking appeared to slow healing and to favor relapses. Moderate consumption of alcohol appeared to decrease the relapse rate. In the present trial, ulcer size was associated with ulcer pain but not with ulcer healing.

Adult↗
PubMed1976

[Carcinoma after gastric operations (author's transl)].

The incidence of carcinoma after gastric operations for benign lesions was analysed in the patient material of five gastroenterologists in private practice in Switzerland. Of 534 such patients 346 had had a gastric resection with gastrojejunostomy (Billroth II), 58 with gastroduodenostomy (Billroth I), and 130 other kinds of gastric operations. Among 326 patients who had a Billroth II procedure there were 21 with proven carcinoma in the residual stomach, but none after Billroth I and other operations. The incidence after Billroth II was 15.1% at or after ten years. Of 69 patients 10-19 years after gastric resection, six had developed carcinoma, compared with 15 of 70 who were 20 years or more after the resection. The incidence is unexpectedly high. On the other hand, among 29361 non-operated patients there were 279 with carcinoma of the stomach. The average interval between operation and the diagnosis of carcinoma in the residual stomach was 23.8 years. It is recommended that gastric resection should if possible be avoided for benign disease. All patients who have had a gastric resection should be endoscopically controlled annually from ten years after the resection onwards.

Adult↗