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Biomedical subjects

E Licht

Publications and source records attributed to E Licht.

13 recordsLinked to original sources
PubMed1994

AIDS presenting as progressive multifocal leukoencephalopathy with clinical response to zidovudine.

Progressive multifocal leukoencephalopathy (PML) due to JC virus can be the initial manifestation of AIDS. A 40-year-old man seropositive for HIV-1 presented with aphasia, hemiparesis, and hemianopsia, and with magnetic resonance imaging of the brain typical of PML. He quickly became bed bound, incontinent, and mute. The diagnosis of PML was established by histopathology in a brain biopsy with positive immunocytochemistry for polyomavirus capsid proteins, and detection of JCV DNA by polymerase chain reaction using JCV-specific primers. High dose zidovudine therapy was initiated (1200 mg/day). Within two weeks the patient began to respond, and after three months he was able to walk and care for himself and was discharged. He lived for two years from the onset of PML. While cytarabine has been the drug most widely used for PML treatment, this is the second confirmed case with apparent response to zidovudine. High dose zidovudine may benefit some previously untreated AIDS patients with onset as PML.

AIDS Dementia Complex↗
PubMed1982

Screening for glaucoma by general medicine residents.

A screening-training program to teach Schiötz tonometry to internal medicine residents was completed. A large number of previously undiagnosed glaucoma cases were detected. Most of the residents had never before performed tonometry. None had previously screened patients in their clinics. Following training, most of the physicians believed themselves to be competent to perform tonometry, although many had not fully mastered the instrument technically. They believed that glaucoma screening should be done by general internists. Although the residents indicated plans to screen their patients for glaucoma, few continued to do so. General internists may be willing to learn to perform tonometry. However, earlier training and more effective role modelling are probably necessary to effect routine screening for glaucoma.

Family Practice↗