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Biomedical subjects

E Lichtenstein

Publications and source records attributed to E Lichtenstein.

119 records · Page 7Linked to original sources
PubMedDate not supplied

Biochemical validation of smoking status: pros, cons, and data from four low-intensity intervention trials.

Biochemical validation of smoking status has long been considered essential, but recent reports have questioned its utility in certain kinds of field trials. We describe efforts to biochemically validate self-reports of smoking cessation from participants in four large-scale randomized trials in outpatient clinics, hospitals, worksites, and dental clinics. These studies included over 5,000 adults smokers who participated in the population-based low-intensity intervention evaluations. At a 1-year follow-up, 798 subjects reported no tobacco use. We attempted to verify these reports using saliva continine/carbon monoxide validation procedures. Overall, there was a moderately high nonparticipation rate (27%), a low disconfirmation rate (4%), and a high self-reported relapse rate (12%) in the interval between survey and biochemical validation. There were no differences between intervention and control conditions on any of the above variables. Longer durations of self-reported abstinence were strongly related to increased probability of biochemical confirmation. Differences in results across projects were related to how biochemical validation was conducted. These results, as well as statistical power considerations, raise questions about whether biochemical validation procedures are practical, informative, or cost-effective in such population-based, low-intensity intervention research.

Adult↗
PubMedDate not supplied

Tobacco cessation interventions in health care settings: rationale, model, outcomes.

Health care settings provide opportunities to reach populations of tobacco users with personalized cessation assistance. We describe a model for doing so which emphasizes a team approach, minimizes the burden on clinicians, and uses brief counseling by allied professionals, videos, written materials, and telephone calls to augment clinician advice. The model has been implemented in several diverse settings including outpatient, inpatient, and dental clinic managed care; fee-for-service dentistry and pediatric practices; and planned parenthood clinics. Data from several randomized trials support the effectiveness of the approach. The brief, low-intensity interventions derived from the model appear to be sustainable on a routine basis in many settings.

Administration, Cutaneous↗
PubMedDate not supplied

Who enrolls in a self-help cessation program for smokeless tobacco?

To further our understanding of the representativeness of the smokeless tobacco (SLT) user recruited to various treatment settings, and to suggest gaps in services available to SLT users, we first compared participants who enrolled in a self-help cessation program with two samples of nontreatment-seeking SLT users: SLT users identified through a random digit dialing (RDD) survey, and SLT users who came to 1 of 75 dental practices for a routine cleaning visit. We found that those in the self-help SLT cessation program were older, more educated, more likely to have made a serious quit attempt, and used more SLT weekly than those who did not seek treatment. Secondly, we compared SLT users seeking treatment in three different treatment settings varying in accessibility and intensity: self-help study participants, SLT users enrolled in a clinic-based study, and callers to the California Help Line for SLT cessation. Participants differed across the three studies on demographics, some measures of dependence, and history of SLT use.

Adult↗
PubMedDate not supplied

Developing a brief measure of smoking in the home: description and preliminary evaluation.

We describe a self-report measure of household smoking exposure and its relationship to ambient nicotine levels as measured by a passive nicotine monitor. Thirty-nine participants placed a passive nicotine monitor in their home for a 7-day period and completed a retrospective household smoking questionnaire. The composite index from the household smoking questionnaire was strongly correlated with air nicotine concentration (r = .74, p < .01). The household smoking questionnaire appears to be a convenient low-response cost method of assessing indoor smoke exposure.

Adolescent↗
PubMedDate not supplied

Evaluating two self-help interventions for smokeless tobacco cessation.

The need for effective, low-cost self-help treatment methods for smokeless tobacco (ST) addiction becomes more evident as rates of product use and associated morbidities increase. This study evaluated two self-help methods for ST cessation. One hundred ninety-eight ST users were randomized into two conditions: half received the LifeSign, a credit card-sized computer designed for gradual ST cessation, and half received the Enough Snuff self-help manual and a video. Subjects in both conditions received telephone support for their quit effort. The study was conducted entirely through phone and mail, allowing delivery of the intervention to both rural and urban users. Self-reported rates of sustained abstinence (no tobacco use at two months and six months) were 24.5% for the manual/video condition, and 18.4%, for the LifeSign condition.

Adolescent↗
PubMedDate not supplied

Changes in smoking associated with hospitalization: quit rates, predictive variables, and intervention implications.

BACKGROUND: Hospitalization can provide one of the most opportune times to prompt smoking cessation. This study determined the frequency of various smoking cessation related behaviors occurring during and following hospitalization and identified variables associated with these outcomes. METHODS: A sample of 526 HMO members who smoked prior to hospitalization and were hospitalized for nonpregnancy related, nonterminal conditions were surveyed to assess the natural history of smoking cessation associated with hospitalization. RESULTS: Three events were studied: not smoking while hospitalized (51% of subjects), attempting to quit following hospitalization (37%), and smoking status one year after hospitalization (16% abstinent). Similar factors were associated with not smoking in the hospital and quit attempts: older persons and patients with circulatory/respiratory diagnoses were only half as likely to smoke in the hospital as other patients and twice as likely to try to quit. Different variables predicted smoking status at follow-up: heavier smokers were significantly more likely to stop (26% cessation) than light or moderate smokers (10% and 11% cessation, respectively). DISCUSSION: The hospital may be an effective setting for smoking cessation programs, especially those aimed at heavy smokers. Research is needed to determine whether smokefree hospital policies alter smoking rates following hospitalization.

Adolescent↗
PubMedDate not supplied

Adolescent health care visits: opportunities for brief prevention messages.

CONTEXT: It has been suggested that clinicians should increase efforts to modify and prevent risky behavior in adolescents. Professional organizations have proposed recommendations about access to care and preventive services, but it is difficult to know where and how to most effectively deliver such services. PRACTICE PATTERN EXAMINED: Clinic visits among adolescent HMO members (14 to 17 years of age). SETTING: Kaiser Permanente Northwest Division, a medium-sized, nonprofit, group-model HMO in the Pacific Northwest. DATA SOURCES: Two administrative databases (one for membership and one for outpatient utilization). RESULTS: A total of 22,626 adolescents who met the inclusion criteria were identified. Of these, 62% (more than 14,000 adolescents) were seen in a primary care clinic within 1 year; almost 83% (more than 18,000 adolescents) were seen within 2 years. There were several opportunities for follow-up for adolescents who had at least one visit in 1995: 60% had more than one visit during 1995, and 80% had more than one visit over the 2-year span of 1995 and 1996. The largest number of adolescent visits occurred in August through November, and most visits took place in the afternoon. CONCLUSIONS: Primary care visits in an HMO present an excellent opportunity to reach many teenagers outside of a school setting. Short-term educational or prevention programs would be optimal during late summer and fall; additional staff members may be able to present these programs after school once school begins.

Adolescent↗
PubMedDate not supplied

Use of a premixed insulin regimen (Novolin 70/30) to replace self-mixed insulin regimens.

The efficacy and safety of transferring 76 patients with poorly controlled type II diabetes mellitus from various self-mixed human insulin regimens to a premixed insulin regimen (Novolin 70/30, 70% NPH and 30% Regular insulin, semisynthetic) were evaluated in a 24-week, multicenter, open-label study. During the initial 12-week run-in period, the patients received twice-daily doses of NPH and Regular human insulin mixed in ratios of 60/40, 80/20, 90/10, or NPH alone, as recommended by their physicians. Subsequently, these patients were transferred to a regimen of Novolin 70/30 twice daily for an additional 12 weeks. In most cases, the transfer was made on a dose-for-dose basis. Following the transfer from self-mixed to premixed insulin, the mean glycated hemoglobin fell from 9.3% to 8.7% at 6 weeks (P < 0.001) and to 8.5% at 12 weeks (P < 0.001). This improved glycemic control was not accompanied by an increase in the frequency or severity of hypoglycemic episodes. It is concluded that patients with type II diabetes mellitus who are poorly controlled on a wide range of self-mixed insulin ratios can be safely transferred, often in a dose-for-dose fashion, to a more convenient 70/30 premixed regimen.

Adult↗
PubMedDate not supplied

Does gender affect response to a brief clinic-based smoking intervention?

INTRODUCTION: Although recent reviews suggest few gender differences in smoking-cessation outcomes, it is important to establish whether gender differences exist in response to the brief interventions increasingly recommended as part of routine medical care. METHODS: We used data from an efficacious primary care-based smoking intervention to examine gender differences in smoking characteristics, use of intervention components, self-reported quitting activities, and cessation outcomes among all smokers randomized to receive clinician advice and nurse-assisted intervention (n = 1,978, 58% female). RESULTS: Although female and male smokers differed on a number of sociodemographic and smoking-related characteristics, they were equally likely to participate in each step of the recommended intervention. Female and male smokers were also equally likely to report quit attempts and cessation at 3, 12, and 3 and 12 months (combined long-term cessation endpoint). Similarly, no gender difference in relapse at 12 months was seen. Women attempting to quit used a greater number and variety of smoking-cessation strategies, suggesting that, although outcomes were similar, the processes of cessation may vary by gender. CONCLUSIONS: Since this brief intervention in primary care was equally efficacious and acceptable to female and male smokers, broader implementation in medical settings of this population-based approach to reducing tobacco use is warranted. Indeed, widespread implementation of smoking-cessation programs in medical settings may particularly benefit women, who are more likely than men to have contacts with the medical care system.

Adult↗