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Biomedical subjects

E Lieberman

Publications and source records attributed to E Lieberman.

At least 109 records · Page 6Linked to original sources
PubMed1981

Premarital rubella screening in Rhode Island.

Rhode Island law requires that rubella serological screening be done for most female marriage license applicants. To evaluate the effect of the law, 203 rubella-susceptible women detected through premarital screening over a four-month period in 1978 were surveyed. Of those responding, 37% had been immunized, 21% were pregnant or infertile, and 42% were eligible for immunization but had not received vaccine. Premarital immunization occurred most frequently when physicians advised and directly offered vaccine. A survey of primary care physicians indicated that 24% immunized none of their rubella-susceptible patients detected by premarital screening.

Adult↗
PubMed1980

The radiological evaluation of intersex: technique of demonstrating Müllerian duct remnants in difficult cases.

In most children born with ambiguous external genitalia urethrography by the flush or catheter technique demonstrates the presence or absence of mullerian duct remnants and allows the appropriate operation to be planned according to the size and development of these remnants. However, in some cases a combined endoscopic and radiographic technique with deliberate retrograde catheterization of the vagina is mandatory. Three illustrative cases are presented.

Adult↗
PubMed1980

The effect of chronic furosemide administration on urinary calcium excretion and calcium balance in growing rats.

The study was designed to determine the calciuretic effect of furosemide and its impact upon calcium balance during chronic (25 days) furosemide administration to growing rats. Experiments were performed on 18 six-wk-old rats. Nine animals received furosemide, and 9 served as controls. The administration of furosemide in a dose of 40 mg resulted in a significant increase in calcium excretion in the treated group; urinary calcium excretion almost doubled that of the controls during the first 24-hr collection (3.74 +/- 0.44 mg in the treated animals compared with 1.90 +/- 0.15 mg in the controls; P less than 0.05). The average daily urinary calcium excretion during each of four subsequent 6-day periods remained approximately three-fold higher in animals which received furosemide compared with controls (P less than 0.001 for each 6-day period). The furosemide-induced increase in urinary calcium excretion did not diminish with time. Sodium excretion did not significantly increase either acutely or chronically in response to furosemide. Daily urinary volume increased approximately 40 to 60% in the furosemide-treated group compared with that of the controls (P less than 0.001). The cumulative calcium balance in the control group exceeded by 7% that of the furosemide-treated animals [2696.3 +/- 20.8 mg versus 2518.6 +/- 20.1 mg (P less than .001]. The findings indicate that distal nephron compensatory mechanisms effecting sodium conservation following furosemide do not result in similar conservation of calcium. Calcium balance may be deleteriously affected.

Administration, Oral↗
PubMed1979

Multiple pituitary hormone deficiencies in eight siblings of one Jewish Moroccan family.

In a Jewish Moroccan inbred family, 8 of 12 siblings were found to have multiple deficiencies of pituitary hormones, including GH, TSH and gonadotrophins. The parents showed no deficiency and are in good health, as are the other 4 siblings. The investigations carried out indicate that in this family the etiology is hereditary in nature, probably being autosomal recessive, with the defect located in the pituitary gland.

Adolescent↗
PubMed1979

Safety of intravenous diazoxide in children with severe hypertension.

The safety and efficacy of diazoxide administered intravenously in the treatment of children with acute severe hypertension have been evaluated by a collaborative study. Observations of the response of blood pressure in 36 patients, ranging in age from two months to 18 years, during the initial episode of hospitalization reveal diazoxide treatment to be effective in lowering blood pressure in 94 per cent of the cases. No serious adverse circulatory, fluid and electrolyte, metabolic or hematologic effects were observed. Symptomatic and subjective reactions observed with diazoxide administered intravenously to children were identical with those described in adults. Reinstitution of other means of antihypertensive therapy is safe and effective when delayed until the transiently induced period of hypotension has passed. Repeated use of diazoxide for subsequent recurrence of severe hypertension was equally effective and safe in 93 per cent of the instances. The results lead us to recommend the use of intravenous diazoxide for treatment of children with severe symptomatic hypertension especially when it is refractory to control by other hypertensive agents.

Adolescent↗
PubMed1977

Childhood pheochromocytoma: treatment with alpha methyl tyrosine for resistant hypertension.

A 12-year-old boy with a norepinephrine-secreting pheochromocytoma that caused hypertension resistant to oral alpha adrenergic blockade is reported. Resistance to alpha adrenergic blocking agents developed when the patient's daily propranolol dosage was lowered from 10 to 1 mg/kg. Subsequently, alpha methyl tyrosine, an inhibitor of tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis, controlled the patient's blood pressure and was associated with reduction in total urinary catecholamine excretion. Norepinephrine content of the tumor and uninvolved adrenal gland removal at surgery was reduced. These findings confirm that alpha methyl tyrosine inhibited in vivo synthesis of catecholamines.

Adrenal Gland Neoplasms↗
PubMed1977

Rhabdomyolysis with severe hypernatremia.

Three children with severe hypernatremia presented with profound generalized weakness and biochemical evidence of rhabdomyolysis and myoglobinuria. These findings in combination have not been previously reported, to our knowledge, in children with severe hypernatremia. Unusual complications included respiratory failure in one child and cardiac arrhythmias in two children. All three children had acute renal insufficiency; one required peritoneal dialysis.

Acute Kidney Injury↗