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Biomedical subjects

E Linnér

Publications and source records attributed to E Linnér.

At least 19 recordsLinked to original sources

The exfoliation syndrome in cognitive impairment of cerebrovascular or Alzheimer's type.

The prevalence of exfoliation syndrome was studied in 39 patients suffering from dementia and cognitive impairment; a positive finding of exfoliation was detected in 11/39 of these patients. A comparison with an age-matched population survey showed that the prevalence of ocular exfoliation and the relative risk were significantly elevated. These results suggested that lesions related to the exfoliative process might be located also in the brain of patients suffering from dementia and cognitive impairment.

Adult↗

Ocular hypertension. A prospective twenty-year follow-up study.

In a prospective study of 41 persons with ocular hypertension followed for 20 years, 14 individuals (34 per cent) developed glaucoma. Of 38 persons who 20 years ago were normotensive, 2 (5 per cent), developed glaucoma. This difference is significant. The mean IOP of the remaining untreated ocular hypertensives was about 7 mmHg higher than the mean tension in the control group.

Aged↗

[Possibility of surface-independent tonography and tonometry].

A method of simultaneous measurement of intraocular pressure and volume displacement is reported. An electronic pressure sensor (diameter 3 mm) was positioned in the centre of the base of a transparent applanation body (diameter 9 mm). The corneal applanation area could be changed by different applanation forces and was measured photographically. In isolated human and porcine eyes, sensor signal and intraocularly measured pressure were related linearly and independently of the applanation area. In human eyes in situ, the rigidity coefficient decreased with increasing pressure. Adhesive forces and stiffness of the cornea obviously only falsify tonometry at the margin of the applanation area.

Biomechanical Phenomena↗

Ocular hypertension. II. A carbonic anhydrase inhibitor test for early detection of glaucoma.

The intraocular pressure before and three h after oral administration of a carbonic anhydrase inhibitor was measured in one normotensive, one hypertensive as well as two glaucoma groups. The ratio between the outflow pressure after and before this treatment was estimated. The percentage outflow pressure was found to be about 50% in the normotensive group and in the two glaucoma groups, but in the hypertensive group 68%. This carbonic anhydrase inhibitor test (CAI-test) seems to give additional information which can improve the possibility of differentiating between high normative pressure and early glaucoma prior to glaucomatous lesions.

Acetazolamide↗

Ocular hypertension. I. The clinical course during ten years without therapy. Aqueous humour dynamics.

An initial group of 152 subjects with moderate ocular hypertension constituted the basic material of the present study. Antiglaucoma treatment was started in 8 men and in 6 women. A remaining group of 92 subjects were kept under clinical observation for ten years without antiglaucomatous therapy and without any evidence of progressive disc cupping or field defects. The intraocular pressure as well as the outflow facility showed a tendency to decrease with time, which was assumed to indicate a reduction in aqueous flow with increasing age. The tomographic findings support the view that the moderately elevated intraocular pressure is mainly due to an increased rate of aqueous flow.

Adult↗