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Biomedical subjects

E Lockey

Publications and source records attributed to E Lockey.

16 recordsLinked to original sources
PubMed1982

Cardioplegia versus intermittent ischaemic arrest in coronary bypass surgery.

No definitive method of myocardial preservation has been established and conclusions based on experimental data may not be applicable to patients with coronary artery disease. Fifty patients undergoing coronary bypass grafting were randomly assigned to one of two groups for myocardial preservation. In group A cold cardioplegia with external cardiac cooling was used and in group B ischaemic arrest with mild systemic cooling to 32 degrees C. Myocardial preservation was assessed by analysis of enzymes specific to the heart, left ventricular biopsy, and electrocardiography. Equal protection of the myocardium was provided in both groups but the mean cross-clamp time in group A was significantly longer than in group B. This implies that cardioplegia confers greater protection than intermittent ischaemic arrest.

Adult↗
PubMed1980

Preoperative carcinoembryonic antigen and survival after resection of lung cancer.

Carcinoembryonic antigen (CEA) was measured preoperatively in 43 patients who underwent complete resection of primary lung cancer. 7 of 43 patients (17%) had CEA levels in the cancer diagnostic range (greater than 40.9 microgram/litre), non of whom survived longer than 10 months. At two years, it was apparent that those patients with a preoperative CEA less than 21 microgram had a better survival rate than those with a CEA21-40.9 microgram/litre (P less than 0.005).

Carcinoembryonic Antigen↗
PubMed1970

Assessment of proximal tubular sodium reabsorption during water diuresis in patients with heart disease.

In order to examine the relation between cardiac state and the capacity to excrete a water load, 10 normal subjects and 61 patients with heart disease were studied during water diuresis. Under these conditions, urine flow approximates to the rate of delivery of filtrate, and therefore of sodium, from the proximal tubule of the kidney to the loop of Henle, while free water clearance is a function of distal sodium reabsorption. In 12 patients with complete heart block, ventricular pacing was associated with increased urine flow and free water clearance. Oral propranolol in 3 normal subjects and in 9 patients with intact atrial septa caused a reduction, and oral practolol in 4 normal subjects and 8 patients caused no change. In 6 patients with atrial septal defect, propranolol was without effect. Maximum urine flow correlated with left ventricular end-diastolic pressure but not mean left atrial pressure in 16 patients with chronic rheumatic heart disease. In 7 patients with ischaemic heart disease, maximum urine flow was higher than in those with chronic rheumatic heart disease and similar increase in left ventricular end-diastolic pressure. These results reflect a close relation between proximal tubular sodium reabsorption and cardiac state, and suggest that inappropriate sodium reabsorption at this site may contribute to fluid retention in heart disease.

Acetanilides↗