The renal net acid excretion (NAE), the blood pH (pHe), the total body intracellular pH (pHi) and the urinary pH (pHu) were calculated in 10 patients with chronic obstructive lung disease and hypercapnia and in 5 normocapnic subjects. The mean value of NAE was significantly higher in hypercapnic subjects than in normocapnic ones. pHe was significantly lower in hypercapnic than in normocapnic subjects. The differences of pHi and pHu between normo and hypercapnic subjects were not significant. NAE is significantly correlated with PaCO2, pHe, pHu and pHi in all the subjects considered together. H+-secretion probably depends on the H+-availability and pHi of tubular cells, but from our results it is not possible to confirm this relationship, because the method used for pHi is fundamentally a measure of muscle-pHi.

Acidosis, Respiratory↗

PubMedDate not supplied

[Hemorheologic characteristics in beta-thalassemic homozygotes before and after splenectomy].

In a group of 36 homozigous beta-thalassaemic children we studied the effect of splenectomy on hemorheologic characteristics. The aim of the work was to evaluate the importance of such operation either on anemia or on erythrocyte deformability. Whole blood viscosity was measured with a Brookfield Microviscometer (LVT) and erythrocyte deformability was evaluated with the erythrocyte filtration technique using policarbonate membranes. The more the erythrocyte deformability decreases, the more the erythrocyte filtration rate decreases. Our data show that splenectomized children, have worse hemorheologic characteristics according to the longer survival time of pathological red blood cells in spite of their reduced deformability. This behaviour can be modified only by blood transfusion that we have seen to be able to reduce whole blood viscosity and to increase erythrocyte filtration rate in splenectomized children. We think that splenectomy must be delayed as long as possible so that hemodinamyc conditions cannot be worsened. An hemorheologic monitorage could be useful for diagnostic and prognostic evaluations both in splenectomized and not splenectomized children.

Adolescent↗

PubMedDate not supplied

[Behavior of glutamic-pyruvic transaminase during the clinical course of acute myocardial infarct].

The increase in serum Alanine-aminotransferase (SGPT) levels in 104 patients with acute myocardial infarction is studied. The time course of serum enzyme changes shows two peaks of activity: in the first days after infarction and at the end of the second week of the disease. The clinical significance of this finding is discussed.

Alanine Transaminase↗

PubMedDate not supplied

Prospective study of airway obstruction in a population with small airway disease.

In this paper, we discuss results showing an increase of bronchial obstruction due to exposure in an iron foundry. The research has been conducted in two steps: in the first, we selected a sample of 100 subjects, all working in the iron foundry, who were affected only by small airway obstruction. In a second step, 30 months later, 99 of these subjects were re-examined and the present airway condition determined. In 43 subjects we found abnormal results of the tests indicating total airway obstruction after the 30 months. After properly accounting for ageing, we found that even in the subsample of non-smokers a deterioration had occurred, showing an effective contribution of environmental pollution. The use of RV, MMEF, CV, DLCO for detecting small airway obstruction is evaluated. The combination of RV, MMEF and CV is the most efficient mosaic of tests for the selection of subjects with small airway obstruction (89%) and with high probability of developing total airway obstruction (44%).

Adult↗

PubMedDate not supplied

[Relations between echocardiography of the pulmonary valve and the hemodynamics of chronic cor pulmonale].

Explore the source record for details and available documents.

Chronic Disease↗

PubMedDate not supplied

[Access to rehabilitation resources for an unselected hospital population of patients with acute seizures].

The study aimed at evaluating selection criteria and basic characteristics of acute stroke patients admitted to rehabilitation programs. From January 1993 to February 1994, 373 patients from 13 hospitals of the Lombardy region were admitted to the study. The 4 months telephone follow-up was performed by the AVO (Hospital Volunteers Association) volunteers. The 4 months fatality rate was 23%. The patients with a higher disability level were prescribed a rehabilitation program. Rehabilitation resources were not available for very severe or dependent patients being mostly the younger and partially dependent patients more often referred to the services. Only 50% of eligible patients received a rehabilitation intervention within 1 month from the index episode of stroke. The lack of caring resources and the long waiting times stress the need for a reorganization of the rehabilitation services. This study also shows that volunteers can play a role of stricter collaboration with doctors and are ready to collaborate in data collection. A larger and more detailed study is warranted in order to gain a better knowledge on the problem and on the clinical and social characteristics of the stroke victims.

Adolescent↗