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Biomedical subjects

E Lopes Cardozo

Publications and source records attributed to E Lopes Cardozo.

13 recordsLinked to original sources
PubMed1978

Adjuvant therapy with levamisole in resectable lung cancer.

In view of the discouraging results that have been obtained so far with the use of cytotoxic chemotherapy as an adjunct to surgery, a double-blind placebo-controlled evaluation of the adjuvant use of levamisole was conducted in 211 resectable lung cancer patients, following these patients for 2 years after their operation. Levamisole (or the placebo) was given for 3 days every 2 weeks and the dose level ranged 1.1--3.8 mg/kg per day (a fixed dose of 3 x 50 mg was given to all patients). It appeared that recurrences and carcinomatous deaths had occurred significantly less often in patients who had received a high dose (i.e., 2.1--3,8 mg/kg: patients weighing 70 kg or less) but not in the patients who received a lower dose. Patients who had more advanced cancers at the time of surgery seemed to have profited more from the treatment, but the results did not seem to depend upon the histologic type of the tumor or on the immune status of the patients as estimated from the skin test reactivity at the start. There was also suggestive evidence that levamisole may be more effective in preventing hematogenous dissemination than in inhibiting recurrences in the lung or the mediastinal tissues. Levamisole, if dosed adequately, appears to be a very suitable adjuvant treatment in resectable lung cancer patients as judged from its efficacy and its lack of troublesome side-effects.

Adenocarcinoma↗
PubMed1975

Lead poisoning with pigmentation of the oral mucosa. Review of the literature and report of a case.

Some general aspects of the pathogenesis and the clinical and oral symptoms of chronic lead intoxication are presented. Treatment procedures are briefly discussed. The case of a patient suffering from plumbism is described. A typical Burtonian line was present in the mouth. By electron microprobe analysis, it was shown that this line was mainly the result of lead and, to a minor extent, the result of mercury-, copper-, and iron-bearing pigment in the subepithelial tissue.

Adult↗