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E Lukas

Publications and source records attributed to E Lukas.

7 recordsLinked to original sources
PubMed1995

Vibratory perception threshold in the lower extremities. Normative values.

Objective was to obtain normative values for the vibratory perception threshold (VPT) in the lower extremities and study the dependence of VPT on various physiological factors. Thirty healthy volunteers: 10 men and 20 women entered in the study. The VPT for 8, 16, 31.5, 63, 125, and 500 Hz were estimated on the right and left external malleolus using the B&K vibration threshold meter, modified type 1800, and the threshold tracking method. The applied static force could not be controlled. The measurements were repeated twice. VPTs expressed as mean +/- SD were as follows: 8 Hz 109 +/- 3.4 dB, 16 Hz 112 +/- 4.1 dB, 31.5 Hz 116 +/- 6.2 dB, 63 Hz 116 +/- 8.4 dB, 125 Hz 117 +/- 8 dB, 250 Hz 125 +/- 9.3 dB, and 500 Hz 136 +/- 13.1 dB. A nomogram was constructed with reference ranges of VPTs for individual frequencies, from which the profile of vibratory perception thresholds can be seen. Moreover, a global index was calculated as a sum of VPTs for individual frequencies. Its reference value was 840 +/- 52 dB and it varied in repeated measurements by up to 9%. No statistically significant difference of VPTs between the right and left side and between the 1st and 2nd examination was found. A tendency to the increase of VPTs with age was observed, which in males reached statistical significance for frequencies 16, 31.5, 63, and 125 Hz.

Adolescent↗
PubMed1975

[Lysosomal hydrolases in the process of muscular atrophy and dystrophy (a histochemical study)].

Non-specific esterase, acid phosphotase, beta-glucoronidase, and N-acetyl-beta-glucosamindase were revealed using the histochemical method of asocombinations in biopsy specimens of the muscular tissue taken from 99 patients suffering from neurogenic and myogenic disorders. Biopsy specimens were taken also from 7 healthy persons. Concentrations of the granular product of the reaction correlated with autofluorescence in the same section. Some bioptic materials were investigated using electron-microscopy. It was established that activity of lysosomal hydrolases in the normal muscular tissue was low, being increased with age. Autofluorescence in the majority of cases was well noticible. In the groups of atrophic fibres in neurogenic atrophy there were observed focal elevation of the lysosomal enzymatic activity. Product of the reaction, which pointed to the activity of nonspecific esterase and acid phosphotase, was localized predominantly along the periphery of muscular fibres. Autofluorescence of the product of the reaction was considerable. On the other hand, there were extensive areas of muscular fibres in which the concentration of the reaction product did not exceed the normal level. Activity of hydrolases in cells of the mesenchyma was of a low degree. Ist type of the lysosomal activity was observed in myogenic dystrophy with an acute course of the disease; it was characterized by structural changes in the muscular tissue, activation of the all hydrolases under study, absence of autofluorescence on the areas of localization of the reaction product, participation of the mesenchyma cells in the lysosomal activation. IInd type of the lysosomal activity was noted in the muscular tissue in neurogenic atrophy. There was no difference in principle between neuro- and myogenic lesions as far as the type of lysosomal activity is concerned. Collation of the results obtained in the investigations with the data reported in available literature enabled the authors to put forward the concept of the two types of the lysosomal activity in muscular lesions: 1) diffuse elevation of the lysosome activity associated with structural changes in the muscular tissue; 2) focal elevation of the physiological activity due to formation of lipopigment.

Acetylglucosaminidase↗