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E Lykouras

Publications and source records attributed to E Lykouras.

15 recordsLinked to original sources
PubMed1989

Platelet monoamine oxidase, plasma dopamine beta-hydroxylase activity, dementia and family history of alcoholism in chronic alcoholics.

The authors measured platelet monoamine oxidase (MAO) activity and plasma dopamine beta-hydroxylase activity in 36 male chronic alcoholics during a period of non-abstinence, and in 29 normal controls. The influence of family history, dementia, chronicity of drinking and liver injury on the enzyme activities was also examined by multiple regression analysis. Platelet MAO was significantly lower in the alcoholic group. Both enzyme activities were negatively related to the presence of dementia, while low MAO activity was associated with positive family history (parents, sibs) of alcoholism.

Adult↗
PubMed1989

Depression among general hospital patients in Greece.

We estimated the prevalence of depression in 150 medical and surgical inpatients. Forty-three patients (29%) scoring at 14 or above on the Beck Depression Inventory (BDI) were classified as depressed. An excess of women and white-collar workers and more stressful life events during the last 12 months were found among the depressed patients. Of the 21 BDI items, 6 differentiated the 43 medical-surgical depressed patients from a group of 43 psychiatric inpatients with a diagnosis of primary or secondary depression (Feighner's criteria). Medically ill depressed patients scored higher in social withdrawal, work inhibition and irritability but lower in loss of libido, sleep disturbance, and lack of satisfaction. Our results show rates of depression in a medical inpatient population in Greece comparable with those in other studies. The use of BDI may help assessment of depression in general hospital patients.

Adolescent↗
PubMed1988

Neurochemical variables in delusional depression.

The authors assayed plasma dopamine beta-hydroxylase activity, platelet monoamine oxidase (MAO) activity, plasma prolactin, the urinary monoamine metabolites 3-methoxy-4-hydroxyphenylglycol (MHPG), 5-hydroxyindoleacetic acid (5-HIAA), and homovanillic acid (HVA), and urinary cAMP from 18 delusional and 22 nondelusional depressed inpatients. No significant differences between the two groups were found.

Adult↗
PubMed1987

Platelet monoamine oxidase and plasma dopamine-beta-hydroxylase activities in non-abstinent chronic alcoholics. Relation to clinical parameters.

Platelet monoamine oxidase (MAO) and plasma dopamine-beta-hydroxylase (DBH) activities were determined in 27 male non-abstinent chronic alcoholics. Compared to 24 normals, no significant difference in both enzyme activities was found. Alcoholics with at least one alcoholic first degree relative had a trend toward lower platelet MAO activity compared to those without such a history. Matched pair analysis showed that alcoholics of the former subgroup had significantly lower MAO activity than controls. Demented alcoholics had significantly reduced plasma DBH activity compared with the non-demented subgroup and with age, and sex, matched controls.

Adult↗
PubMed1986

Delusional depression: phenomenology and response to treatment. A prospective study.

In a prospective study, the authors compared 22 delusional and 36 non-delusional depressive patients with respect to demographic and clinical variables, personality, and response to treatment. Delusional depressives had a higher total score than non-delusional depressives on Hamilton's Rating Scale for Depression, as well as a higher score for depressed mood and psychomotor retardation. The type of treatment failed to differentiate the two groups as to outcome at discharge. However, six of the seven delusional depressives who did not respond to tricyclic antidepressants had a full recovery with ECT. The results indicate that delusional depression represents a more severe type of major depression.

Adolescent↗
PubMed1986

Delusional depression: phenomenology and response to treatment.

In this retrospective study demographic and clinical characteristics, personality traits, family psychiatric history and response to treatment were compared in 55 delusional and 40 nondelusional hospitalized patients who met DSM-III criteria for major depression. Male delusional depressives had a greater frequency of delusional ideas at the index episode than female delusionals. Delusional depressives had a greater frequency of family history for alcoholism, a smaller frequency of previous depressive episodes and tended to respond more favorably to treatment with electroconvulsive therapy or tricyclic antidepressants combined with neuroleptics than to antidepressants alone. The findings and the implications arising from them are discussed.

Antidepressive Agents, Tricyclic↗
PubMed1985

Type and content of delusions in unipolar psychotic depression.

In a prospective study the authors compared unipolar psychotic and non-psychotic patients for the presence of delusional ideation in previous episodes. Psychotic patients had a significantly higher frequency of delusions in previous episodes. The type and content of delusional ideas were similar from episode to episode. The results and their implications are discussed.

Delusions↗
PubMed1984

Disturbances of perception in depressive patients.

In a sample of 121 depressive patients hospitalized at Eginition Hospital from 1976 to 1980, 22 (18.2%) patients manifested disturbances of perception and, with 1 exception, all patients had hallucinations. Auditory and visual hallucinations were the most frequent. The group of patients with disturbances of perception had a positive family history for affective illness (p less than 0.025), a smaller number of previous depressive episodes (p less than 0.05), a greater frequency of delusional thinking (p less than 0.001) and psychomotor agitation (p less than 0.05).

Adult↗
PubMed1983

Neuroses and ABO blood types.

Determination of ABO blood types was carried out in 72 (35 female and 37 male) patients with obsessive-compulsive neurosis, 73 (35 female and 38 male) patients with phobic neurosis, 75 (54 female and 21 male) patients with hysteria and a random sample of 600 individuals (268 female and 332 male) drawn from the general population. Results provide evidence of: (1) a positive association between obsessive-compulsive neurosis and blood type A and a corresponding negative association between the former and blood type O; (2) a positive association between phobic neurosis and blood type O and a corresponding negative association between the former and blood type A, and (3) a positive association between hysteria and blood type A and a corresponding negative association between the former and blood type O. Moreover, sex does not appear to modify the ABO blood type distribution in our patients with obsessive-compulsive neurosis, phobic neurosis or hysteria. These findings might be considered as supporting the view that hereditary factors in the neurotic individual may influence the clinical form of his neurosis.

ABO Blood-Group System↗
PubMed1982

Subtypes of schizophrenia and ABO blood types.

Determination of ABO blood types was carried out in 430 (171 female and 259 male) patients with hebephrenic schizophrenia and in 340 (155 female and 185 male) patients with paranoid schizophrenia. Results were compared with a random sample of 600 individuals (268 female and 332 male) drawn from the general population. No significant association was detected between any of the ABO blood phenotypes and affliction either with hebephrenic or paranoid schizophrenia

ABO Blood-Group System↗
PubMed1979

Physical activity and plasma cyclic adenosine monophosphate levels in manic-depressive patients and healthy adults.

Intense exercise for one hour induced a significant increase in plasma cyclic adenosine monophosphate (cAMP) in 5 healthy volunteers. In 44 manic-depressive patients, cAMP levels correlated more strongly with mood ratings than with activity scores. The authors conclude that physical activity is one of the factors which contribute to changes of cAMP levels in affective illness.

Bipolar Disorder↗
PubMed1978

Plasma cyclic AMP in manic-depressive illness.

The postulated disturbance of cyclic AMP (cAMP) in manic-depressive illness was investigated by using plasma as the biological material. Cyclic AMP was measured by a protein-binding assay, which was found very satisfactory for the purpose of this study. In the drug-free state, depressed patients (n = 28) had significantly lower and manic patients (n = 9) significantly higher plasma concentrations of cAMP than controls. Unmedicated manic-depressive subjects had normal cAMP levels during normothymic phases (n = 7). Cyclic AMP was reduced by neuroleptics in mania and elevated by tricyclics in depression. Lithium exerted a normalizing effect on cAMP in both phases of the illness. It is concluded that manic-depressive illness is associated with a disturbance in the cAMP system. The use of plasma rather than urine for the investigation of the state of cAMP in psychiatric disorders is advocated.

Adult↗
PubMedDate not supplied

Recurrence risk for the relatives of delusional depressed patients.

The recurrence risks for major depression among the relatives of patients with delusional depression have been calculated using a computer program. The risk tables have been based on the data from the 454 first-degree relatives of 77 probands with delusional depression, the 503 first-degree relatives of 76 non-delusional probands and the 980 first-degree relatives of 153 controls. The results showed that: the familial aggregation of the delusional depression seem to follow the multifactorial pattern of inheritance (segregation analysis), the heritability of the delusional depression was found to be 62, the recurrence risk varies from 0.5% to 36.2% for the various relatives and tables for recurrence risks are provided.

Adult↗