Biomedical subjects

E M Airaksinen

Publications and source records attributed to E M Airaksinen.

3 recordsLinked to original sources

PubMed1979

Uptake of taurine by platelets in retinitis pigmentosa.

Uptake of 3H-taurine by platelets from twelve patients with retinitis pigmentosa (R.P.) and from healthy controls was measured. Platelets were incubated in autologous plasma with 3H-taurine for different times and at different substrate concentrations. The uptake of taurine by R.P. platelets at each incubation time was about two-thirds of the control value, the difference being statistically significant. Km was about the same, but Vmax was lower in R.P. platelets. The results suggest that R.P. is a disease affecting not only the eye but also taurine transport and/or storage in general.

Adolescent↗

PubMed1979

Uptake of taurine, GABA, 5-HT, and dopamine by blood platelets in progressive myoclonus epilepsy.

The uptakes of four neurotransmitters (taurine, GABA, 5-HT, and dopamine) by blood platelets from patients with degenerative-type progressive myoclonus epilepsy (PME) and from controls were studied using different incubation times and different concentrations. Only the uptakes of taurine differed significantly between patients and controls: patients' uptakes were 70% to 80% of control values at 10, 30, 60, and 120 min of incubation time. Km values were approximately the same, but Vmax values in PME patients were lower, showing quantitative but not qualitative differences in taurine uptake by platelets in PME. These results suggest that a defect or an inhibitory mechanism of some factor needed in the transport or binding of taurine (but not of GABA, 5-HT, and dopamine) is present in PME.

Adolescent↗

PubMed1975

Platelet taurine in Down's syndrome.

Endogenous platelet taurine and uptake of radioactively labelled taurine by platelets was measured in normal, non-mongoloid and mentally retarded mongoloid trisomy 21 subjects. Endogenous taurine was normal in all groups, while taurine transport kinetic experiments showed normal Km but reduced Vmax in mongoloid trisomy 21 and mentally retarded patients. The latter difference may be due to decreased metabolism following decreased enzyme protein synthesis.

Adolescent↗